Huidige banen gerelateerd aan 2 Phd Students Hypertrophic Cardiomyopathy - Amsterdam Zuid - Amsterdam UMC
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PhD Student in Cellular Neuroscience
3 dagen geleden
Amsterdam, Noord-Holland, Nederland Vrije Universiteit Amsterdam VoltijdJob Title: PhD Student in Cellular NeuroscienceWe are seeking a highly motivated PhD student to join our research group at Vrije Universiteit Amsterdam. The successful candidate will work on a project investigating the mechanisms of mRNA localization and translation in neurons.Job Description:The PhD student will be responsible for investigating the dynamics...
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PhD Student in Plasma Catalysis
16 uur geleden
Amsterdam, Noord-Holland, Nederland ARCNL VoltijdJob DescriptionWe are seeking a highly motivated PhD student to join our team at the Advanced Research Center for Nanolithography (ARCNL) in Amsterdam, The Netherlands. The successful candidate will be part of the Materials and Surface Science for EUV Lithography group and will work on a fully funded PhD project entitled "Resolving Surface Reactions in...
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Functiebeschrijving van PhD-student in Machine Learning
1 week geleden
Amsterdam, Noord-Holland, Nederland Centrum Wiskunde & Informatica VoltijdFunctiebeschrijvingCentrum Wiskunde & Informatica (CWI) zoekt drie getalenteerde PhD-studenten voor een onderzoeksgroep Stochastics.ProjectbeschrijvingWe zoeken PhD-studenten die zich willen specialiseren in het ontwikkelen van nieuwe modellen, methoden en machine-learning technieken voor de bestrijding van cyberdreiging.VerantwoordelijkhedenOntwikkelen van...
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PhD Student in Cellular Neuroscience
2 weken geleden
Amsterdam, Noord-Holland, Nederland VU Amsterdam VoltijdJob DescriptionProject OverviewThe VU Amsterdam is seeking a highly motivated PhD student to join our research team in the Department of Functional Genomics. The successful candidate will be part of an international research network and will contribute to the development of novel methods for analyzing cellular neuroscience.Research FocusThe PhD student will...
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PhD Student in Machine Learning for Cybersecurity
3 dagen geleden
Amsterdam, Noord-Holland, Nederland Centrum Wiskunde & Informatica VoltijdJob Vacancy: PhD Student in Machine Learning for CybersecurityCWI, the Dutch national research institute for mathematics and computer science, is seeking three talented PhD students to join our Stochastics group. We are looking for individuals with a strong background in machine learning and a passion for cybersecurity.About the ProjectThe project focuses on...
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PhD-Student in Cellular Neuroscience
4 weken geleden
Amsterdam, Nederland VU Amsterdam VoltijdYour functionThe CNCR in Amsterdam (see participates in the Graduate School ONWAR ( and is seeking applications for a PhD-student in cellular neuroscience (Synaptic physiology, High-resolution imaging) for the Department of Functional Genomics, VU/Amsterdam University Medical Center, Amsterdam.Project: Mechanisms of neuropeptide signaling in human...
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PhD Student in Cellular Neuroscience
1 week geleden
Amsterdam, Noord-Holland, Nederland Vrije Universiteit Amsterdam VoltijdAbout the ProjectThis research project aims to investigate the mechanisms of dense-core vesicle (DCV) trafficking and secretion in human neurons. Using CRISPR/Cas9 gene editing and live-cell imaging, we aim to uncover how neuropeptides are regulated and linked to brain disorders.Job DescriptionWe are seeking a highly motivated PhD student to join our...
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PhD Student in Cellular Neuroscience
1 week geleden
Amsterdam, Noord-Holland, Nederland Vrije Universiteit Amsterdam VoltijdAbout the ProjectThis research project aims to investigate the mechanisms of dense-core vesicle (DCV) trafficking and secretion in human neurons. Using CRISPR/Cas9 gene editing and live-cell imaging, we seek to uncover how neuropeptides are regulated and linked to brain disorders.Job DescriptionWe are seeking a highly motivated PhD student to join our...
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PhD-Student in Cellular Neuroscience
4 weken geleden
Amsterdam, Nederland VU Amsterdam VoltijdYour functionThe CNCR in Amsterdam (see participates in the Graduate School ONWAR ( and is seeking applications for a PhD-student in cellular neuroscience (Synaptic physiology, High-resolution imaging) for the Department of Functional Genomics, VU/Amsterdam University Medical Center, Amsterdam.Project: Mechanisms of neuropeptide signaling in human...
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PhD-Student in Cellular Neuroscience
1 maand geleden
Amsterdam, Nederland VU Amsterdam VoltijdYour functionThe CNCR in Amsterdam (see participates in the Graduate School ONWAR ( and is seeking applications for a PhD-student in cellular neuroscience (Synaptic physiology, High-resolution imaging) for the Department of Functional Genomics, VU/Amsterdam University Medical Center, Amsterdam.Project: Molecular mechanisms of functional diversity in...
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PhD Student in Cellular Neuroscience
3 dagen geleden
Amsterdam, Noord-Holland, Nederland Amsterdam UMC VoltijdJob Title: PhD Student in Cellular NeuroscienceWe are seeking a highly motivated PhD student to join our research group at the Amsterdam UMC. The successful candidate will work on a project focused on understanding the molecular mechanisms that control the plasticity of axonal initial segments.Job Description:Conduct live-cell and superresolution imaging...
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PhD-Student in Cellular Neuroscience
4 weken geleden
Amsterdam, Nederland Vrije Universiteit Amsterdam VoltijdThis project investigates the mechanisms of dense-core vesicle (DCV) trafficking and secretion in human neurons. Using CRISPR/Cas9 gene editing and live-cell imaging, it aims to uncover how neuropeptides are regulated and linked to brain disorders. Jouw functie The CNCR in Amsterdam participates in the Graduate School ONWAR (www.ONWAR.nl) and is seeking...
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PhD Student in Cellular Neuroscience
5 dagen geleden
Amsterdam, Noord-Holland, Nederland Vrije Universiteit Amsterdam VoltijdProject OverviewThe Vrije Universiteit Amsterdam is seeking a highly motivated PhD student to investigate the mechanisms of mRNA localization and translation in neurons. The project aims to uncover the role of organelle interactions in coordinating mRNA transport, localization, and translation in neurons.Key ResponsibilitiesInvestigate the dynamics of...
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PhD-Student in Cellular Neuroscience
4 weken geleden
Amsterdam, Nederland Vrije Universiteit Amsterdam VoltijdJoin our Amsterdam-based team to investigate molecular mechanisms of synaptic plasticity using advanced imaging and protein labelling. Ideal for a neuroscience Master’s graduate with relevant lab skills and passion for research.Jouw functieThe CNCR in Amsterdam (see www.cncr.nl) participates in the Graduate School ONWAR (www.ONWAR.nl) and is seeking...
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Internships for PhD students
2 maanden geleden
Amsterdam, Nederland Centrum Wiskunde & Informatica VoltijdJob description We offer a three-month internship at CWI under the supervision of a CWI researcher who supports your visit. Your travel to Amsterdam will be paid for, and your accommodation in Amsterdam is fully arranged and covered by the internship program. You will also receive a monthly stipend of 1200 euros to help cover your daily expenses. ...
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PhD-Student in Cellular Neuroscience
4 weken geleden
Amsterdam, Nederland Vrije Universiteit Amsterdam VoltijdThis project investigates the mechanisms of dense-core vesicle (DCV) trafficking and secretion in human neurons. Using CRISPR/Cas9 gene editing and live-cell imaging, it aims to uncover how neuropeptides are regulated and linked to brain disorders.Jouw functieThe CNCR in Amsterdam (see www.cncr.nl) participates in the Graduate School ONWAR (www.ONWAR.nl)...
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PhD Student in Cellular Neuroscience
1 week geleden
Amsterdam, Noord-Holland, Nederland Vrije Universiteit Amsterdam VoltijdProject OverviewThe Vrije Universiteit Amsterdam is seeking a highly motivated PhD student to investigate the dynamics of organelles and mRNAs in neurons. The project aims to uncover the mechanisms that ensure the correct localization, capture, and translation of mRNAs in neurons, which is crucial for brain function and disease prevention.Key...
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PhD Student in Cellular Neuroscience
59 minuten geleden
Amsterdam, Noord-Holland, Nederland Vrije Universiteit Amsterdam VoltijdProject OverviewWe are seeking a highly motivated PhD student to join our research group at Vrije Universiteit Amsterdam. The project focuses on deciphering how mRNAs are captured at specific subcellular locations to support local translation in neurons. This ERC-funded project aims to investigate the mechanisms that ensure the correct localization, capture,...
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Research Internship for PhD Students
1 week geleden
Amsterdam, Noord-Holland, Nederland Centrum Wiskunde & Informatica VoltijdInternship OpportunityWe are offering a three-month internship at Centrum Wiskunde & Informatica (CWI) for PhD students. The internship will be supervised by a CWI researcher who will provide guidance and support throughout the visit.BenefitsThe internship includes:Travel to Amsterdam will be paid forAccommodation in Amsterdam will be fully arranged and...
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Research Internship for PhD Students
3 dagen geleden
Amsterdam, Noord-Holland, Nederland Centrum Wiskunde & Informatica VoltijdInternship OpportunityWe are offering a three-month internship at Centrum Wiskunde & Informatica (CWI) for PhD students. The internship will be supervised by a CWI researcher who will provide guidance and support throughout the visit.BenefitsThe internship includes:Travel to Amsterdam will be paid forAccommodation in Amsterdam will be fully arranged and...
2 Phd Students Hypertrophic Cardiomyopathy
3 maanden geleden
**About the project**:
**Per September 1**st** 2024**, we have a vacancy for two PhD students to work in the group of **Dr. Diederik Kuster** within the **Department of Physiology** at Amsterdam UMC. The PhD students will be involved in international projects studying **hypertrophic cardiomyopathy (HCM)** disease mechanism and building new tools to understand drug response on the cellular level.
HCM affects ~1:200 - 1:500 people. It is the most common inherited cardiac disease. Clinically defined by a unexplained growth of the heart muscle, HCM patients also show impaired relaxation and an increased arrhythmia risk. In more than half of the patients an causative mutation can be identified. These mutations are in the contractile proteins of the sarcomere. Even though these mutations have been known for >30 years, how they lead to a bigger and poorly relaxing heart is not well understood. Over the years the groups of Dr Kuster and Prof van der Velden have contributed to mechanistic and translational knowledge of HCM. These new and exciting projects aim to **1)** shed led on the disease mechanisms and** 2)** understand and expand our knowledge on drug response to increase relaxation.
**1) **We aim to study the role of the Z-disc in HCM, as this is what couples sarcomeres (contractile units) to each other and is an important mechanosensor in the cell. Based on existing data, major changes are seen in Z-disc morphology and protein expression. We will measure Z-disc changes in human patient samples, study the mechanism for Z-disc remodeling in human induced pluripotent stem cell derived cardiomyocytes and engineered heart tissue. This project is a collaboration between Amsterdam UMC, the University of Birmingham and Charité in Berlin.
**2) **Our group has extensive expertise in developing tools to measure contraction/relaxation of cardiomyocytes. We are there first that performed drug screenings in cardiomyocytes. We have found a high level of variability in drug response. The mechanism behind this variability is completely unknown. We will develop a new setup that can perfuse and measure individual cardiomyocytes. This allows us to perform for the first time drug responses on an individual cell level. By integrating molecular analysis we will be able to understand the biology of the variable response and test compounds that improve drug effectiveness. This is a collaborative project with small companies from Amsterdam and Sweden.
**About the role**:
As a PhD student you will work in an internationally-orientated research environment, where your main tasks and responsibilities are:
- Set-up, plan and conduct studies, often in collaboration with other researchers in the Department of Physiology and international partners
- Collaborate with clinical partners to study disease mechanisms in explanted cardiac tissue;
- Conduct studies in a recently developed mouse model of HCM;
- Train MSc and BSc students who work with you on your project;
- Writing and publishing scientific manuscripts and other reports on study results;
- Present and disseminate research results at (international) conferences.
This work will result in a PhD thesis based in international, peer-reviewed publications. Training in research and transferable skills are part of the PhD trajectory.
**Profile**:
We are looking for an enthusiastic and ambitious researcher with a strong motivation for doing science. You have a strong interest in physiology, cell and molecular biology and development of new methodologies.
- MSc degree in Medical Natural Science, Biomedical Science, Medicine, Biomedical Engineering Biochemistry or a related discipline;
- High level of independence and the ability to take ‘ownership’ of the project, but are also a pleasant team player able to work with people from different backgrounds;
- Experience with basic science
- A good command, both spoken and written, of the English language.
**Our offer**:
- We offer an initial contract for 12 months that can be extended (after evaluation) for another 36 months.
- Salary scale: OIO (3.017 tot 3.824 euro based on a 36 hour week), depending on qualifications and experience. The monthly wage will increase yearly to the maximum wage in the fourth year of EUR 3.824 gross per month.
- Additional benefits including an 8.3% end-of-year bonus and 8% holiday pay. Calculate your net salary here.
- Your pension is accrued at BeFrank. A modern and fair pension scheme
- Excellent accessibility with public transportation and reimbursement of a large portion of your travel expenses. Additionally, we have plenty of parking spaces and a good bicycle scheme.
For more information about our employment conditions, please visit our website.
**About the workplace**:
The **Department of Physiology **at Amsterdam UMC (location VUmc) performs research in the area of muscle structure and function. The research groups use state-of-the-art physiological and imaging setups, animal models, stem cell-d
