PhD Student Photopharmacology
1 maand geleden
Without biological membranes, there would be no life as we know it. Transport of molecules and information across these membranes is carried out by integral membrane protein channels, receptors, pumps and transporters. Living cells maintain chemical gradients and electrical potential differences across their membranes using proteins that represent the majority of all current drug targets. Therefore, membrane proteins have been the focus of intense efforts to obtain high resolution macromolecular structure information. However, the current lack of experimental methods to carry out time-resolved structural studies of membrane proteins at physiological temperatures and under physiological gradients leaves a gigantic blind spot is our mechanistic understanding.
This project is a part of an ERC-funded consortium that will address this challenge by bringing together complementary expertise in membrane protein biology, time-resolved structural studies, photochemistry and nano fabrication methods. The role of the PhD working in this position will be to design, synthesize and evaluate new light-activated molecules to deliver protein transport substrates with unprecedented efficiency. Within this team, the PhD student will be supported, among others, by a dedicated postdoc researcher with expertise in quantum chemistry for guiding the development of light-activated molecules.
Organization
The vacancy is within the newly formed Department of Medicinal Chemistry, Photopharmacology and Imaging at the Groningen Research Institute of Pharmacy, Faculty of Science and Engineering, University of Groningen. The ERC-funded (ERC Synergy GRAIL) project aims at providing molecular basis for the instant, photochemical release of ligands for proteins studied in unprecedented level of structural dynamics using equipment developed by the GRAIL consortium.
The University of Groningen (founded in 1614) has a long tradition of academic excellence, being one of the oldest research universities in Europe. The University is currently in or around the top 100 on several influential ranking lists. Currently approximately 34,000 students are enrolled and about 1,500 PhD students work on their theses. The city of Groningen is a historic town and among the ten biggest cities in The Netherlands. It is a vibrant student town with a direct train connection to Schiphol Airport near Amsterdam.
The Groningen Research Institute of Pharmacy (GRIP) is part of the Faculty of Science and Engineering (FSE) of the University of Groningen and collaborates closely with the University Medical Center Groningen (UMCG). The pharmaceutical and medical research within GRIP and the UMCG is very multidisciplinary. This project aims to develop light-activation processes for the emerging field of time-resolved structural biology, fitting perfectly into the fundamental and applied work performed in the Department of Medicinal Chemistry, Photopharmacology and Imaging at GRIP. Qualifications
We are looking for an enthusiastic and talented PhD candidate with
- a M.Sc. degree in (Synthetic) Organic Chemistry
- research experience in the field of photochemistry, photocleavable protecting groups and/or photopharmacology will be seen as a strong asset
- capacity to think analytically and creatively
- high motivation
- ability to work in an international team and collaborate with several research centres in Europe in a streamlined and professional way
- an integrative and cooperative personality with excellent communicative and social skills
- fluent proficiency in English – written and oral.
Applicants whose first language is not English must submit evidence of competency in English, please see University of Groningen’s English Language Requirements for details. Organisation Conditions of employment
We offer you in accordance with the Collective Labour Agreement for Dutch Universities
- a salary of € 2,770 (salary scale PhD candidates) gross per month in the first year, up to a maximum of € 3,539 gross per month in the fourth and final year, based on a full-time position
- a holiday allowance of 8% gross annual income an 8.3% year-end bonus
- a temporary position of one year with the option of renewal for another three years; prolongation of the contract is contingent on sufficient progress in the first year to indicate that you will successfully complete your PhD thesis within the next three years. A PhD training programme is part of the agreement.
The preferred starting date is between September 1st and October 1st 2024.
-
PhD-student pre-clinical testing adhesives
2 dagen geleden
Groningen, Nederland Universitair Medisch Centrum Groningen VoltijdWe are looking for a motivated, enthusiastic PhD-student with a research-oriented mind, who is able to independently set up and carry out experiments. You should be comfortable in working and communicating in a multi-disciplinary team, with the ability to coordinate a project between multiple research groups and sites. Do you recognize yourself in this? If...
-
PhD-student pre-clinical testing adhesives
2 dagen geleden
Groningen, Groningen, Nederland Universitair Medisch Centrum Groningen VoltijdWe are looking for a motivated, enthusiastic PhD-student with a research-oriented mind, who is able to independently set up and carry out experiments. You should be comfortable in working and communicating in a multi-disciplinary team, with the ability to coordinate a project between multiple research groups and sites. Do you recognize yourself in this? If...
-
PhD student in the field of culturomics of the infant microbiome
4 weken geleden
Groningen, Nederland Universitair Medisch Centrum Groningen VoltijdWe have an open PhD position to validate several findings garnered from metagenomic and metabolomic surveys of the infant gut microbiome. We aim to broaden our ecological and evolutionary understanding of the processes and patterns than influence colonization of the infant gut via wet lab experiments. Job description The work of our group has characterized...
-
PhD Decision Biases in Family Firms Internationalization
4 dagen geleden
Groningen, Nederland University of Groningen VoltijdJob description Since its foundation in 1614, the University of Groningen has enjoyed an international reputation as a dynamic and innovative center of higher education offering high-quality teaching and research. Belonging to the best research universities of Europe and joining forces with prestigious partner universities and networks, the University of...
-
PhD Machine learning meets choice models
4 dagen geleden
Groningen, Nederland University of Groningen VoltijdJob description Since its foundation in 1614, the University of Groningen has enjoyed an international reputation as a dynamic and innovative center of higher education offering high-quality teaching and research. Belonging to the best research universities of Europe and joining forces with prestigious partner universities and networks, the University of...
-
Phd Investigating Modern Organizational Structures
7 dagen geleden
Groningen, Nederland Rijksuniversiteit Groningen VoltijdSince its foundation in 1614, the University of Groningen has enjoyed an international reputation as a dynamic and innovative center of higher education offering high-quality teaching and research. Belonging to the best research universities of Europe and joining forces with prestigious partner universities and networks, the University of Groningen is truly...
-
PhD Decision Biases in Family Firms Internationalization
4 dagen geleden
Groningen, Groningen, Nederland University of Groningen VoltijdJob descriptionSince its foundation in 1614, the University of Groningen has enjoyed an international reputation as a dynamic and innovative center of higher education offering high-quality teaching and research. Belonging to the best research universities of Europe and joining forces with prestigious partner universities and networks, the University of...
-
PhD Machine learning meets choice models
4 dagen geleden
Groningen, Groningen, Nederland University of Groningen VoltijdJob descriptionSince its foundation in 1614, the University of Groningen has enjoyed an international reputation as a dynamic and innovative center of higher education offering high-quality teaching and research. Belonging to the best research universities of Europe and joining forces with prestigious partner universities and networks, the University of...
-
PhD student: Optimizing monitoring and care in Phenylketonuria
5 dagen geleden
Groningen, Nederland Universitair Medisch Centrum Groningen VoltijdWe zijn op zoek naar een getalenteerde, enthousiaste, gemotiveerde PhD-student met interesse voor onderzoek naar het verbeteren van de psychologische en sociale vraagstukken bij een specifieke stofwisselingsziekte, phenylketonurie. Je bent in staat tot zelfstandig werken, maar bent vooral ook een team player. Het Onderzoek Ben jij nieuwschierig hoe we de...
-
Groningen, Nederland University of Groningen VoltijdJob description Since its foundation in 1614, the University of Groningen has enjoyed an international reputation as a dynamic and innovative center of higher education offering high-quality teaching and research. Belonging to the best research universities of Europe and joining forces with prestigious partner universities and networks, the University of...
-
Groningen, Groningen, Nederland University of Groningen VoltijdJob descriptionSince its foundation in 1614, the University of Groningen has enjoyed an international reputation as a dynamic and innovative center of higher education offering high-quality teaching and research. Belonging to the best research universities of Europe and joining forces with prestigious partner universities and networks, the University of...
-
Groningen, Nederland UMCG VoltijdFunctiebeschrijving Tijdens je stage ga je voor de faculteit gezondheidswetenschappen (geneeskunde, tandheelkunde, biomedische wetenschappen, farmaceutische wetenschappen) de proefschriftendatabase langs van de afgelopen 20 jaar. Per proefschrift breng je in kaart of ongepubliceerde hoofdstukken uiteindelijk wel/niet gepubliceerd zijn. Mochten...
-
Student voor interprofessioneel onderwijs in de geboortezorg
2 weken geleden
Groningen, Nederland Universitair Medisch Centrum Groningen VoltijdReageer t/m 14 mei Solliciteer Delen: Geplaatst op 17 oktober 2023 Functiebeschrijving Voor dit onderzoek ga je gebruik maken van design based research als onderzoekmethode. (7) (Dolmans 2012). Deze methode volgt de verschillende de stappen van implementatie en de interactie daarbij met stakeholders (studenten, docenten/zorgprofessionals en patiënten). Met...
-
Groningen, Nederland University of Groningen VoltijdJob description Since its foundation in 1614, the University of Groningen has enjoyed an international reputation as a dynamic and innovative center of higher education offering high-quality teaching and research. Belonging to the best research universities of Europe and joining forces with prestigious partner universities and networks, the University of...
-
PhD Toward local resilient food systems in developed economies
4 dagen geleden
Groningen, Nederland University of Groningen VoltijdJob description Since its foundation in 1614, the University of Groningen has enjoyed an international reputation as a dynamic and innovative center of higher education offering high-quality teaching and research. Belonging to the best research universities of Europe and joining forces with prestigious partner universities and networks, the University of...
-
Groningen, Nederland University of Groningen VoltijdJob description Since its foundation in 1614, the University of Groningen has enjoyed an international reputation as a dynamic and innovative center of higher education offering high-quality teaching and research. Belonging to the best research universities of Europe and joining forces with prestigious partner universities and networks, the University of...
-
Groningen, Groningen, Nederland University of Groningen VoltijdJob descriptionSince its foundation in 1614, the University of Groningen has enjoyed an international reputation as a dynamic and innovative center of higher education offering high-quality teaching and research. Belonging to the best research universities of Europe and joining forces with prestigious partner universities and networks, the University of...
-
PhD Toward local resilient food systems in developed economies
4 dagen geleden
Groningen, Groningen, Nederland University of Groningen VoltijdJob descriptionSince its foundation in 1614, the University of Groningen has enjoyed an international reputation as a dynamic and innovative center of higher education offering high-quality teaching and research. Belonging to the best research universities of Europe and joining forces with prestigious partner universities and networks, the University of...
-
Groningen, Groningen, Nederland University of Groningen VoltijdJob descriptionSince its foundation in 1614, the University of Groningen has enjoyed an international reputation as a dynamic and innovative center of higher education offering high-quality teaching and research. Belonging to the best research universities of Europe and joining forces with prestigious partner universities and networks, the University of...
-
PhD Retirement Finance: solving the asset allocation puzzle
4 dagen geleden
Groningen, Nederland University of Groningen VoltijdJob description Since its foundation in 1614, the University of Groningen has enjoyed an international reputation as a dynamic and innovative center of higher education offering high-quality teaching and research. Belonging to the best research universities of Europe and joining forces with prestigious partner universities and networks, the University of...