Phd Position in Biofabrication and Bioprinting for

1 week geleden

Utrecht, Utrecht, Nederland UMC Utrecht Voltijd

We are seeking an ambitious PhD student for our multidisciplinary team to build new technological solutions for developmental biology and preclinical research.

You will develop bioprinted tissues to generate and expand hematopoietic stem cells.
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Dit ga je doen


Hematopoietic stem cell (HSC) production is a vital process for maintaining a healthy blood system and enabling life-saving treatments like HSC transplantations.

Producing HSCs in the laboratory would revolutionize medical treatments by providing transplantation options for nearly all patients in need. Yet, much remains to be learned about the generation and growth of HSCs.

Research in this area has faced significant challenges due to limitations in studying the native birthplace of HSCs within embryos in the aorta, and the absence of suitable laboratory models.

To overcome these obstacles, we are pioneering an innovative volumetric 3-dimensional bioprinting technology (ultra-fast bioprinting developed in our lab), crafting miniature artificial replicas of the embryonic aorta.

We will use our bioprinted tissue to explore how blood flow and haemodynamics, environmental biomechanical and biochemical signals, and various local geometrical changes influence HSC production.

Our work will form the foundation for groundbreaking discoveries and will ultimately aid to produce HSCs in our bioprinted and perfusable mini-factories.


This PhD position is part of the multidisciplinary ZonMw Open Competition funded project entitled "b3D-AGM, a bioengineered cradle to produce bona fide hematopoietic stem cells in vitro.


Your challenge within this project is to develop a volumetric 3D bioprinting strategy to replicate the mechanical and chemical environment of the embryonic aorta, simulate different hemodynamic flow profiles in _computational_ and experimental set-ups, and to develop dynamic perfusion and culture regimes, needed for tissue engineering and HSC generation.


Hier ga je werken

Dit neem je mee

  • You hold a Master's degree in biomedical engineering, biophysics, bioengineering, materials science, mechanical engineering or related disciplines.
  • Strong interest to collaborate with consortium partners with background in developmental biology.
  • Expertise in 3D bioprinting, additive manufacturing and biomaterials.
  • Expertise in fluid dynamic simulation and finite element analysis will be positively evaluated.
  • Expertise in cell culture and tissue engineering will be positively evaluated.
  • Ability to work in a multidisciplinary research environment and to contribute to team efforts and projects.
  • Ability to communicate effectively scientific ideas, foster collaboration and independent thinking.
  • Proven proficiency in written and spoken English.

Dit bieden we jou

  • A salary between € 3017 and € 3824 gross per month (salary scale OIO), based on fulltime employment (36 hours).
  • A 4year fulltime PhD student position in the interdisciplinary area of biomaterials, biofabrication and regenerative medicine. The initial contract will be for a period of one year, which will be extended to a total of four years upon successful assessment
  • Yearend bonus of 8.3% and holiday allowance of 8%.
  • Pension insurance with ABP. We take care of approximately 70% of the monthly contribution.
  • Access to a variety of online courses through GoodHabitz.
  • The option to select additional employment benefits in exchange for gross salary, such as purchasing a bicycle and memberships.


Wij geloven in de kracht van een divers team waarin ruimte is voor verschillende vaardigheden, expertises, sociale en culturele achtergronden.

Wij zijn benieuwd naar jou

  • Onze nieuwe collega's werven we zelf. We hebben geen behoefte aan acquisitie._

Sollicitatieprocedure
-
Een leuke vacature gevonden?- **Dank voor je sollicitatie*
  • Je ontvangt meteen een ontvangstbevestiging van ons. **Selectieproces*
  • Binnen twee weken na sluiting vacature hoor je van ons of je bent uitgenodigd **Eerste gesprek*
  • Samen kijken we of er een match is. **Tweede gesprek*
  • Bij een match volgt er een voorstel arbeidsvoorwaarden of assessment. **Welkom*
  • Wat fijn dat je bij ons aan de slag gaat Heel veel werkplezier
    Kom meer te weten over werken bij het UMC Utrecht

Dit bieden we jou

  • Kom je bij ons werken? Dan geldt voor jou de cao umc. Daarnaast bieden we je nog veel meer en organiseren we van alles zodat jij jezelf kan blijven ontwikkelen.

Samen zijn wij UMC Utrecht

  • Wij geloven in de kracht van een divers team waarin ruimte is voor verschillende vaardigheden, expertises, sociale en culturele achtergronden. Wij zijn benieuwd naar jou

Kom je langs

  • Binnen het UMC Utrecht organiseren we regelmatig evenementen. Zo kan jij je goed oriënteren op werken bij ons ziekenhuis

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