Technician in Vitro Adme Metabolism

Req ID #:222408
Location:

Den Bosch (S-Hertogenbosch), NL, 5231 DD- For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies.

When you join our family, you will have a significant impact on the health and well-being of people across the globe.

Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform.

In return, we'll help you build a career that you can feel passionate about.
Job Summary

• Are you up for a new challenge? For our invitro Metabolism Team in Den Bosch we have a challenging opportunity for a technician with a wide variety of tasks._
• Do you like to work in a dynamic team and be responsible for multiple studies at the same time?_
• Then I encourage you to read the vacancy below_

For our team in Den Bosch we are currently hiring a:

Technician in vitro ADME metabolism-dermal absorption

Department:

The Discovery & Environmental Sciences department consists of approximately 90 employees. Within this department, research is carried out into the safety of existing and new substances. Characteristic of the work is the great diversity of tests, test substances, customers, and collaborations.

The section in vitro ADME (IVA):

This section is a young and dynamic section that investigates the Absorption, Distribution, Metabolism and Excretion of various compounds (e.g., new medicines, (agro-) chemicals and consumer products).

For our in vitro studies we make use of various non-animal test systems including human skin tissue, cell cultures, microsomes and supporting analytical techniques (e.g radio-HPLC/ LC-MS/MS, qPCR).

Due to the increasing workload, we have an opportunity for a technician:
in vitro ADME metabolism / dermal absorption.

About your role:

As a technician you work in a dynamic team under supervision of a Study Director.

You will mainly be responsible for the performance of a diversity of in vitro metabolism studies which will include performance of the assays, sample pre-treatment and sample analysis with LC-MS/MS.

In addition, you are involved in the implementation and validation of new studies.

In addition, you will also assist in the performance of in vitro dermal absorption studies using human skin tissue and radiolabelled or non-radiolabelled formulations.

Specific tasks include a.o.

radiochemical purity performance with radio-HPLC, preparation, testing and analysis of (topical) formulations and the execution of in vitro dermal absorption studies, incl.

processing of data.

What is required:

• A relevant HBO education (e.g. HLO); with a focus on analytical chemistry / biochemistry.

hours per week availability.

• Experience with LC-MS equipment, LC-MS method development and validation.
• Interest in identification of unknown compounds; familiarity with Empower and Masslynx.
• Affinity and experience with biological systems.
• You have a handson attitude and 'outofthebox' mentality and enjoy improvising and troubleshooting.
• You have a proactive, resultsoriented, enthusiastic, dynamic and flexible attitude.
• You have good communication and presentation skills, both in Dutch and English.

Nice to have:

• Understanding of Good Laboratory Principles (GLP).
• Certification to work with radioactive materials.
• Experience with or knowledge of the preparation of (topical) formulations.
• Offer

Our offer:

Working at our organization means working in a dynamic international organization with a modern laboratory and a wide variety of equipment and techniques at your disposal.

In addition, we offer excellent primary and secondary working conditions including:

• Ongoing training and support.
• 27.5 holidays and 2 collective days per year.
• Possibility to purchase 10 additional holidays per year.
• Annual oneoff 8% holiday pay of your gross annual salary.
• Annual oneoff payment based on company results.
• Travel allowance at €0.23 cents per kilometer with a maximum of €250 net per month or an NS Business Card.
• Bicycle (lease) plan.
• Collective pension with a small own contribution of 2.9%.
• Company fitness membership.
• The opportunity to play sports with colleagues on our own sports field.
• The possibility of a consultation with our inhouse ergonomist.
• Free fresh fruit every day.

Do you have any questions about this vacancy?

Acquisition in response to this vacancy is not appreciated.

About Safety Assessment

Charles River is committed to helping our partners expedite their preclinical drug development with exceptional safety assessment services, state-of-the-art facilities and expert regulatory guidance.

From individual specialty toxicology and IND enabling studies to tailored packages and total laboratory support, our deeply experienced team can design and execute programs that anticipate challenges and avoid roadblocks for a smooth

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