LC-MS Analyst Metabolisme in vitro ADME

For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about. Vergroot uw kans op een sollicitatiegesprek door het volgende overzicht van deze functie te lezen voordat u solliciteert. Job Summary Are you up for a new challenge? For our in vitro Metabolism Team in Den Bosch we have a challenging opportunity for a LC-MS analyst metabolism with a wide variety of tasks and responsibilities. At Charles River Laboratories Den Bosch we are currently hiring a: LC-MS Analyst Metabolisme in vitro ADME Department The Discovery & Environmental Sciences department consists of approximately 90 employees. Within this department, research is carried out into the safety of existing and new substances. Characteristic of the work is the great diversity of tests, test substances, customers and collaborations. The Section In Vitro ADME (IVA) This section is a young and dynamic section that investigates the absorption, distribution and metabolism of different compounds. These can be pharmaceuticals, agrochemicals, chemicals and food ingredients. The studies are performed in in-vitro models like hepatocytes, microsomes, but also in blood or plasma. We also perform the analytical analysis with LC-MS to quantify compounds in the in-vitro models. In order to investigate metabolites formed in these in-vitro models, we work with state-of-the-art high resolution MS instruments. The team consists of 9 study directors and 13 technicians. Within the team there is an open and flexible culture and a pleasant and informal atmosphere, where everyone supports each other and where you are valued. About Your Role As a technician you work in a dynamic team under supervision of a Study Director. You will mainly be responsible for the performance of a diversity of in vitro metabolism studies which will include performance of the assays, sample pre-treatment and sample analysis with LC-MS/MS. You will also perform development, implementation and validation of the required analytical methods. In addition, you are involved in the implementation and validation of new studies. You will be working in a recently renovated laboratory (2021) equipped with state-of-the-art analytical equipment. Your Profile A relevant HBO education (e.g. HLO); with a focus on analytical chemistry / biochemistry Experience with chromatography and mass spectrometry (LC-MS/MS), both method development and validation Interest in identification of unknown compounds; familiarity with data processing software such as Xcalibur, Compound Discoverer, Empower and Masslynx Affinity and experience with biological test systems Certification to work with radioactive materials is a plus You have a hands-on attitude and ‘out-of-the-box’ mentality and enjoy improvising and troubleshooting You have a pro-active, results-oriented, enthusiastic, dynamic and flexible attitude You have good communication and presentation skills, both in Dutch and English Understanding of Good Laboratory Principles (GLP) is a pré Our Offer Working at our organization means working in a dynamic international organization with a modern laboratory and a wide variety of equipment and techniques at your disposal. In addition, we offer excellent primary and secondary working conditions including:   Ongoing training and support; 27.5 holidays and 2 collective days per year; Possibility to purchase 10 additional holidays per year; Annual one-off 8% holiday pay of your gross annual salary; Annual one-off payment based on company results; Travel allowance at €0.23 cents per kilometer with a maximum of €250 net per month or an NS Business Card; Bicycle (lease) plan; Collective pension with a small own contribution of 2.9%; Company fitness membership; The opportunity to play sports with colleagues on our own sports field; The possibility of a consultation with our in-house ergonomist; Free fresh fruit every day. About Safety Assessment Charles River is committed to helping our partners expedite their preclinical drug development with exceptional safety assessment services, state-of-the-art facilities and expert regulatory guidance. From individual specialty toxicology and IND enabling studies to tailored packages and total laboratory support, our deeply experienced team can design and execute programs that anticipate challenges and avoid roadblocks for a smooth, efficient journey to market. Each year approximately 300 investigational new drug (IND) programs are conducted in our Safety Assessment facilities. About Charles River Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market. With over 20,000 employees within 110 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly worked on 80% of the drugs approved by the U.S. Food and Drug Administration (FDA) in the past five years. At Charles River Laboratories, we recognize and recruit all talent. Xnkfpon We are a company committed to fostering a sense of belonging and work daily in this direction. 231261