Neutrophils Meet Auto-antibodies: a Joint Phd

3 weken geleden

Amsterdam Zuid, Nederland Amsterdam UMC Voltijd

**About the project**:
Rheumatoid arthritis (RA) is a chronic disabling autoimmune disease with an unknown aetiology. The van Egmond and van Baarsen labs both work on unique research angles to better understand the pathophysiology of RA, which now come together in this project.

The van Baarsen lab is the only group in the world where lymph node (LN) biopsies from healthy individuals and patients with or at risk of inflammatory arthritis (IA) are collected and studied. They observed a high number of infiltrating neutrophils in lymph nodes of patients diagnosed with RA.

The van Egmond lab investigates the activation of neutrophils by (auto-)antibodies, and demonstrated that particularly antibodies of the IgA isotype potently activate neutrophils, and induce neutrophil migration. The finding that the presence of IgA autoantibodies predates clinical onset of disease has sparked interest for IgA in the rheumatology research field. Van Baarsen and van Egmond now join forces to investigate the hypothesis that IgA autoantibodies induce the recruitment of neutrophils into the lymph nodes of RA patients, which subsequently steers adaptive immune responses.

Both labs have complementarity tools to tackle this novel hypothesis. The van Baarsen lab has access to unique human samples, and the van Egmond lab recently created novel mouse models. By studying tissue samples from both early stage RA patients as well as (IgA)
- autoantibody positive individuals at risk of disease, and through the use of novel and unique technologies, including spatial transcriptomics, this project aims to obtain fundamental new insights in the function of LN neutrophils and their role in RA. Ultimately, gained knowledge may lead to novel therapeutic targets to redirect skewed autoimmune responses in RA and possibly other autoimmune diseases.

The title of the project is "Lymph node neutrophils in inflammatory arthritis: the missing link between innate and adaptive autoimmunity?"

**About the role**:
As a PhD student on this project you will:

- Establish detailed ex vivo spatial phenotyping of neutrophils in tissue samples (lymph node and synovium) from patients with RA and investigate their relation with clinical parameters including IgA and IgG autoantibody levels;
- Determine neutrophil function and activation by patient autoantibodies;
- Determine the in vivo role of neutrophils and IgA in inflammatory arthritis;
- Work closely with our team and collaborators on this project;
- Author manuscripts submitted to high quality peer-reviewed journals resulting in a PhD thesis;
- Present your work at conferences;
- Be involved in supervising students.

**Profile**:
We are looking for a highly motivated and enthusiastic researcher with:

- A master degree Biomedical Sciences or equivalent, with affinity for Immunology;
- Experience with cellular responses, molecular biology, and experience with animals (article 9) is preferred;
- You have a flexible, proactive team spirit but you can also work independently;
- You have excellent communications skills in English, both written and verbal.

**Our offer**:

- A jump start to your research career.
- Plenty of room for your drive to shape tomorrow's healthcare.
- Working on large-scale and your own research project, with motivated colleagues from all over the world.
- A fixed term contract for 1 year. With a positive evaluation, this will be prolonged with 3 years. The position is for 4 years.
- The opportunity to develop further such as through training.
- Classification in salary scale OIO: € 2,901 to € 3,677 gross for full-time employment (depending on education and experience).
- In addition to a good basic salary, you will receive an 8.3% end-of-year bonus and 8% holiday allowance. Calculate your net salary here.
- Pension accrual at BeFrank, a modern, responsible and fairly priced pension.
- Excellent accessibility by public transport and reimbursement of a large part of your travel costs. We also have sufficient parking spaces at location AMC and a good bicycle scheme.

**About the workplace**:
AMC Medical Research (AMR) is located at location AMC. AMR supports scientific research in non-profit settings. AMR provides researchers with everything they need to excel. For example, AMR offers principal investigators (PIs) and project leaders guidance in the areas of project management, finance and human resources. Legal support is also provided for medical-scientific research projects. Watch the video below for more information.

Start your new job at AMR

**Let's meet**:
A reference check, screening and hiring test may be part of the procedure. Read here whether that applies to you. If you join us, we ask you for a VOG (Certificate of Good Conduct).

Acquisition in response to this vacancy is not appreciated.

  • Phd Student B Cell Modulation By Antibodies

    3 weken geleden

    Amsterdam, Nederland Sanquin Voltijd

    **Location** - Amsterdam **Working week** - 36 hours **Education** - WO **Closing date** - 10 May 2024 **Function area** - Research / Laboratory **Vacancy nr.** - 1078 **About Sanquin** Sanquin Blood Supply Foundation combines medical, diagnostic, blood bank and research activities within one organisation. With 2,000 committed colleagues and 345,000...

  • Phd Neutrofielen en Auto-antilichamen Bij

    3 weken geleden

    Amsterdam Zuid, Nederland Amsterdam UMC Voltijd

    **Wat ga je onderzoeken**: Reumatoïde artritis (RA) is een chronische auto-immuunziekte met een onbekende oorzaak. De laboratoria van van Egmond en van Baarsen werken gezamenlijk aan een uniek onderzoeksproject om de pathofysiologie van RA beter te begrijpen. Neutrofielen zijn witte bloedcellen die een cruciale rol spelen in het afweersysteem, met name bij...

  • Phd Neutrofielen en Auto-antilichamen Bij

    2 weken geleden

    Amsterdam Zuid, Nederland Amsterdam UMC Voltijd

    **Wat ga je onderzoeken**:Reumatoïde artritis (RA) is een chronische auto-immuunziekte met een onbekende oorzaak. De laboratoria van van Egmond en van Baarsen werken gezamenlijk aan een uniek onderzoeksproject om de pathofysiologie van RA beter te begrijpen.Neutrofielen zijn witte bloedcellen die een cruciale rol spelen in het afweersysteem, met name bij...

  • Phd - Department of Physiology

    2 weken geleden

    Amsterdam Zuid, Nederland Amsterdam UMC Voltijd

    **About the project**: Prof P.L. Hordijk - **Innovative modelling of the human microcirculation by merging vascular cell biology with computational science** In this project, we will study the molecular basis of endothelial integrity in the context of acute and chronic inflammatory responses. Recent work from our group showed that a rapid cycle of protein...

  • Phd - Department of Physiology

    2 weken geleden

    Amsterdam Zuid, Nederland Amsterdam UMC Voltijd

    About the project:Prof P.L. Hordijk - Innovative modelling of the human microcirculation by merging vascular cell biology with computational scienceIn this project, we will study the molecular basis of endothelial integrity in the context of acute and chronic inflammatory responses. Recent work from our group showed that a rapid cycle of protein synthesis...

  • Phd Position: Software Architecture for

    4 weken geleden

    Amsterdam Zuid, Nederland Vrije Universiteit Amsterdam Voltijd

    **Your function**: With the current hype around generative AI and large language models (LLMs), one approach to partly mitigate the lack of common-sense reasoning of systems relying solely on machine learning (ML) is **neuro-symbolic AI**, i.e., synergistically combining the neural AI tradition via deep learning and artificial neural networks and the...

  • Phd Muscles in a Dish for Discovering The Origins

    2 weken geleden

    Amsterdam Zuid, Nederland Amsterdam UMC Voltijd

    **About the project**: **About the projects** Dr. E. Eringa/J. de Winter - **Muscles in a dish for discovering the origins of type 2 diabetes** In this project, we will study disrupted communication between fat tissue, capillaries and muscle cells as an early cause of type 2 diabetes. We will create human muscles in a dish from muscle fibres with human...

  • Phd Position in Improving Machine Learning Methods

    2 weken geleden

    Amsterdam, Nederland Universiteit van Amsterdam Voltijd

    PhD Position in Improving Machine Learning Methods for Contingent Claim Pricing and Hedging **Faculteit/Dienst**:Faculteit der Natuurw., Wiskunde & Informatica**Opleidingsniveau**:Master**Functie type**:Promotieplaats**Sluitingsdatum**:7 June 2024**Vacaturenummer**:12897- The Stochastics group at the Korteweg de Vries Institute at the University of...

  • Phd Muscles in a Dish for Discovering The Origins

    2 weken geleden

    Amsterdam Zuid, Nederland Amsterdam UMC Voltijd

    About the project:About the projectsDr. E. Eringa/J. de Winter - Muscles in a dish for discovering the origins of type 2 diabetesIn this project, we will study disrupted communication between fat tissue, capillaries and muscle cells as an early cause of type 2 diabetes. We will create human muscles in a dish from muscle fibres with human capillary...

  • Phd Position: Software Architecture for

    2 weken geleden

    Amsterdam Zuid, Nederland Vrije Universiteit Amsterdam Voltijd

    Your function:With the current hype around generative AI and large language models (LLMs), one approach to partly mitigate the lack of common-sense reasoning of systems relying solely on machine learning (ML) is neuro-symbolic AI, i.e., synergistically combining the neural AI tradition via deep learning and artificial neural networks and the symbolic AI...

  • Phd Candidate in Developmental or Educational

    4 weken geleden

    Amsterdam Zuid, Nederland Vrije Universiteit Amsterdam Voltijd

    **Your function**: Children’s reading proficiency is closely related to their self-beliefs, such as their mindset, and socio-emotional well-being. Current practices for early assessment of reading proficiency, e.g. to detect reading problems, are known to be biased by children’s socioeconomic status (SES) and (multi)lingual background, and thereby might...

  • Phd Position in Improving Machine Learning Methods

    2 weken geleden

    Amsterdam, Noord-Holland, Nederland Universiteit van Amsterdam Voltijd

    PhD Position in Improving Machine Learning Methods for Contingent Claim Pricing and HedgingFaculteit/Dienst:Faculteit der Natuurw, Wiskunde & InformaticaOpleidingsniveau:MasterFunctie type:PromotieplaatsSluitingsdatum:7 June 2024Vacaturenummer:12897- The Stochastics group at the Korteweg de Vries Institute at the University of Amsterdam and the Actuarial...

  • Phd Candidate in Developmental or Educational

    2 weken geleden

    Amsterdam Zuid, Nederland Vrije Universiteit Amsterdam Voltijd

    Your function:Children's reading proficiency is closely related to their self-beliefs, such as their mindset, and socio-emotional well-being. Current practices for early assessment of reading proficiency, e.g. to detect reading problems, are known to be biased by children's socioeconomic status (SES) and (multi)lingual background, and thereby might...

  • Phd Cellular Neuroscience

    3 weken geleden

    Amsterdam Zuid, Nederland Amsterdam UMC Voltijd

    **About the project**: The title of the project is: _In vitro_ human cortical microcircuits to advance stem cell-based precision medicine for neurodevelopmental disorders. Monogenetic neurodevelopmental disorders (mNDDs) affect about 1 in 6 children in the EU for which currently no general effective therapy exists. This project is part of the ZonMW-open...

  • Phd and Postdoc Positions at Vusec

    4 dagen geleden

    Amsterdam Zuid, Nederland Vrije Universiteit Amsterdam Voltijd

    **Your function**: VUSec performs world-leading research in the broad area of systems security. We work on attacks, defenses, reverse engineering, and formal verification of security. We cover all major areas where security is important, especially software security, hardware security, and network security. We love to work on low-level stuff, for example...

  • PhD Position: Software Architecture for Neuro-Symbolic AI

    2 weken geleden

    Amsterdam, Noord-Holland, Nederland VU Amsterdam Voltijd

    Your functionAre you an experienced and passionate Computer Science researcher with a track record in software engineering or artificial intelligence? Do you want to contribute and collaborate to shape the future of human-centric computing models and applications with an eye on society? Then keep reading, this fully-funded PhD position at Vrije Universiteit...

  • PhD: Fano4nano

    2 weken geleden

    Amsterdam, Noord-Holland, Nederland AMOLF Voltijd

    Two PhD positions: Fano4nano - Fano resonance enhanced scatterometry for wafer metrologyWork ActivitiesAre you looking for a challenging project in which you develop fundamental advances in metaphotonics and work with high-tech industry to apply them? In this project we aim to develop nanophotonic structures for application in high-precision semiconductor...

  • Phd Position Metahealth

    4 weken geleden

    Amsterdam Zuid, Nederland Vrije Universiteit Amsterdam Voltijd

    **Your function**: The aim of this PhD project is to delve into the mechanisms underlying the establishment of a healthy host-oral microbiome balance in early life **Your duties** Your responsibilities are 1. improving the existing 3D reconstructed human gingiva model in order to better mimic the microbial exposure infants encounter in their oral cavity;...

  • Phd Position in Structural

    1 week geleden

    Amsterdam Zuid, Nederland Vrije Universiteit Amsterdam Voltijd

    **Your function**: **Your duties** Your role will be to: - develop data analysis methods tailored to ODORWISE - formulate testable hypotheses on how to exploit biological mechanisms for the rational design of protein targets - validate the models through existing experiments and in collaboration with experimental partners - supervise M.Sc. research...

  • Phd Cellular Neuroscience

    2 weken geleden

    Amsterdam Zuid, Nederland Amsterdam UMC Voltijd

    About the project:The title of the project is: _In vitro_ human cortical microcircuits to advance stem cell-based precision medicine for neurodevelopmental disorders.Monogenetic neurodevelopmental disorders (mNDDs) affect about 1 in 6 children in the EU for which currently no general effective therapy exists. This project is part of the ZonMW-open program...