Phd Student Cytokine Signaling in Macrophages

3 dagen geleden

AmsterdamZuidoost, Nederland Amsterdam UMC Voltijd

**About the project**:
You will be investigating cytokine signaling pathways in macrophages, beyond the known JAK-STAT signaling pathways. Cytokines shape the macrophage’s phenotype, thereby affecting disease states. Puzzlingly, many cytokines with opposing functions, utilize highly similar JAK-STAT signaling cascades, leaving it unclear how cytokine-specific responses can occur.

The goal is to reveal novel, cytokine-specific factors regulating macrophage cytokine responses.

**About the role**:
Your main tasks and responsibilities within this project are:

- Identify transcription factors that regulate macrophage cytokine responses using a natural genetic variation screen;
- Validate and functionally test the identified transcription factors by knockdown/knockout strategies on the cytokine responses of macrophages;
- Next to cell culture experiments, you will use and analyze state-of-the-art approaches such as RNA-sequencing and ChIP-sequencing analysis;
- Translate your findings to disease models;
- Align these findings with human disease.

**Profile**:

- You have a master's degree in a field related to biomedical sciences, (medical) biology, biochemistry or bioinformatics;
- You have experience in molecular biology, immunology and transcriptional regulation;
- You are willing to learn how to perform transcriptomic and genomic data analysis and bioinformatics;
- You have excellent communication skills in English, both written and oral;
- You are an enthusiastic team player with positive social skills;
- Experience with bioinformatics (e.g. in R) is preferred.

**Our offer**:

- A flying start to your research career.
- All the space for your drive to shape tomorrow's healthcare.
- Working on large-scale and your own research, with motivated colleagues from all over the world.
- A fully funded PhD position for 4 years in accordance with the Collective Labour Agreement for University Medical Centers (CAO-UMC). We offer you a contract for one year, to be extended with three years, after a successful evaluation in the first year.
- Your salary will be in salary scale OIO: € 3.017 gross per month in the first year to € 3.824 gross per month in the final (4th) year based on a full-time employment.
- In addition to a good basic salary, you will also receive an 8.3% year-end bonus and an 8% holiday allowance. Calculate your net salary here.
- Pension accrual at BeFrank, a modern, understandable and fairly priced pension.
- Excellent accessibility by public transport and reimbursement of a large part of your travel costs. In addition, we have sufficient parking spaces at the AMC location and a good bicycle scheme.

**About the workplace**:
You will work in the team of Dr. Hoeksema at the department of Medical Biochemistry (see group's website) in the Amsterdam UMC, location AMC. You will work in a team with young and enthusiastic researches (PhD-students, postdocs and technicians) with excellent infrastructure who have expertise in immunology, cell biology, molecular biology, epigenetics, gene regulation and cardiovascular disease.

You will be part of the Amsterdam institute for Immunology and Infectious Diseases and the Amsterdam UMC Doctoral School with the opportunity to follow several (immunology-related) courses.

This project is supported by an ERC Starting grant.

**Let's meet**:
**Note: The first round of interviews is scheduled for Wednesday 5th or Thursday 6th of June 2024. We ask you to take this into account in advance.**

A reference check, screening and hiring test may be part of the procedure. Read here whether that applies to you. If you join us, we ask you for a VOG (Certificate of Good Conduct).

Acquisition in response to this vacancy is not appreciated.

  • Promovendus Cytokine Signaling in Macrophages

    2 maanden geleden

    Amsterdam-Zuidoost, Nederland Amsterdam UMC Voltijd

    **Wat ga je onderzoeken**: Je onderzoekt cytokine-signaleringsroutes in macrofagen, buiten de al bekende JAK-STAT-signaleringsroutes. Cytokines vormen het fenotype van de macrofaag en beïnvloeden zo de ziektetoestanden. Vreemd genoeg gebruiken veel cytokines met tegengestelde functies sterk vergelijkbare JAK-STAT-signaleringscascades, waardoor het...

  • Promovendus Cytokine Signaling in Macrophages

    3 dagen geleden

    Amsterdam-Zuidoost, Nederland Amsterdam UMC Voltijd

    **Wat ga je onderzoeken**: Je onderzoekt cytokine-signaleringsroutes in macrofagen, buiten de al bekende JAK-STAT-signaleringsroutes. Cytokines vormen het fenotype van de macrofaag en beïnvloeden zo de ziektetoestanden. Vreemd genoeg gebruiken veel cytokines met tegengestelde functies sterk vergelijkbare JAK-STAT-signaleringscascades, waardoor het...

  • Promovendus Cytokine Signaling in Macrophages

    1 week geleden

    Amsterdam-Zuidoost, Noord-Holland, Nederland Amsterdam UMC Voltijd

    **Wat ga je onderzoeken**:Je onderzoekt cytokine-signaleringsroutes in macrofagen, buiten de al bekende JAK-STAT-signaleringsroutes. Cytokines vormen het fenotype van de macrofaag en beïnvloeden zo de ziektetoestanden. Vreemd genoeg gebruiken veel cytokines met tegengestelde functies sterk vergelijkbare JAK-STAT-signaleringscascades, waardoor het...

  • Phd Student

    1 week geleden

    Amsterdam, Noord-Holland, Nederland Netherlands Cancer Institute Voltijd

    Function description: The Netherlands Cancer Institute (NKI) forms together with the Antoni van Leeuwenhoek Hospital a Comprehensive Cancer Center, combining excellence in all stages of anticancer research and patient care. It is located in Amsterdam and conducts research in all major areas of oncology, with special emphasis on immunology, cancer cell...

  • Phd Student Emma Center for Personalized

    2 maanden geleden

    Amsterdam-Zuidoost, Nederland Amsterdam UMC Voltijd

    **About the project**: The PhD student will work on gene therapy development for Gyrate atrophy of the choroid and retina (GACR), a rare genetic (neuro)metabolic eye disorder. Based on disease pathology, patient’s needs, ethical considerations, therapeutic developmental time lines, and current state of the art of gene therapy, we recently posed that the...

  • Phd Student Emma Center for Personalized

    3 dagen geleden

    Amsterdam-Zuidoost, Nederland Amsterdam UMC Voltijd

    **About the project**: The PhD student will work on gene therapy development for Gyrate atrophy of the choroid and retina (GACR), a rare genetic (neuro)metabolic eye disorder. Based on disease pathology, patient’s needs, ethical considerations, therapeutic developmental time lines, and current state of the art of gene therapy, we recently posed that the...

  • Phd Student Proteomics in Hemostasis

    2 weken geleden

    Amsterdam, Nederland Sanquin Voltijd

    **Location** - Amsterdam **Working week** - 36 hours **Education** - WO **Closing date** - 15 June 2024 **Function area** - Research / Laboratory **Vacancy nr.** - 1082 **Clinical proteomics in hemostatic disorders** Congenital and acquired disorders of hemostasis represent a large clinical burden. The mission of the Medical Priority Bleeding &...

  • Phd Student Emma Center for Personalized

    1 week geleden

    Amsterdam-Zuidoost, Noord-Holland, Nederland Amsterdam UMC Voltijd

    About the project:The PhD student will work on gene therapy development for Gyrate atrophy of the choroid and retina (GACR), a rare genetic (neuro)metabolic eye disorder. Based on disease pathology, patient's needs, ethical considerations, therapeutic developmental time lines, and current state of the art of gene therapy, we recently posed that the most...

  • Phd - Department of Physiology

    7 dagen geleden

    Amsterdam Zuid, Nederland Amsterdam UMC Voltijd

    **About the project**: Prof P.L. Hordijk - **Innovative modelling of the human microcirculation by merging vascular cell biology with computational science** In this project, we will study the molecular basis of endothelial integrity in the context of acute and chronic inflammatory responses. Recent work from our group showed that a rapid cycle of protein...

  • Drie getalenteerde PhD studenten

    1 week geleden

    Amsterdam, Noord-Holland, Nederland Centrum Wiskunde & Informatica Voltijd

    Centrum Wiskunde & Informatica (CWI) heeft vacatures binnen de onderzoeksgroep Stochastics voor Drie getalenteerde PhD studenten (m/v/x), over het onderwerp "Machine Learning voor de bestrijding van cyberdreiging". Functiebeschrijving De afgelopen jaren is cyberdreiging dramatisch toegenomen met (potentieel) grote impact op het goed functioneren van...

  • Phd-student: Nanophotonics and Quantum Physics with

    3 weken geleden

    Amsterdam Oost, Nederland AMOLF Voltijd

    **PhD-student: Nanophotonics and quantum physics with electrons and light**: **Work Activities**: Did you know high-energy electrons can serve as efficient sources of optical excitation of matter? Our group has developed cathodoluminescence microscopy, in which we use 1-30 keV electrons in a scanning electron microscope (SEM) to excite nanomaterials. The...

  • Phd Student

    4 weken geleden

    Amsterdam, Nederland Netherlands Cancer Institute Voltijd

    **Function description**: - The Netherlands Cancer Institute (NKI) forms together with the Antoni van Leeuwenhoek Hospital a Comprehensive Cancer Center, combining excellence in all stages of anticancer research and patient care. It is located in Amsterdam and conducts research in all major areas of oncology, with special emphasis on immunology, cancer cell...

  • Phd Student

    2 dagen geleden

    Amsterdam, Nederland Netherlands Cancer Institute Voltijd

    **Function description**: - The Netherlands Cancer Institute (NKI) forms together with the Antoni van Leeuwenhoek Hospital a Comprehensive Cancer Center, combining excellence in all stages of anticancer research and patient care. It is located in Amsterdam and conducts research in all major areas of oncology, with special emphasis on immunology, cancer cell...

  • Phd Student Zonmw Project

    2 weken geleden

    Amsterdam, Nederland Netherlands Cancer Institute Voltijd

    **Function description**: - The labs of Alan Gerber (Amsterdam UMC - Location VUmc) and Fred van Leeuwen (Netherlands Cancer Institute, NKI) are teaming up to crack the code of gene regulation of tRNA genes. In a project supported by ZonMW, we will address how the hundreds of tRNA genes in our genome are regulated in their own unique way in response to...

  • PhD-student: Physical learning machines

    1 week geleden

    Amsterdam, Noord-Holland, Nederland AMOLF Voltijd

    PhD-student: Physical learning machinesWork ActivitiesThe Learning Machines group seeks motivated PhD students to join our team working on learning in physical systems. What are learning machines? Imagine your favorite artificial intelligence \ machine learning system figuring out how to solve a task, possibly classifying images of cats and dogs; now imagine...

  • PhD- student: Resolving Surface Reactions in Plasma Catalysis

    1 week geleden

    Amsterdam, Noord-Holland, Nederland ARCNL Voltijd

    PhD- student: Resolving Surface Reactions in Plasma Catalysis (SURPLAS)Work ActivitiesSurface reactions on metal model catalysts in plasma environmentActivation of molecules in a plasma can form the basis for efficient chemical reactions making direct use of electrical energy. The interaction of plasma-activated species with a catalyst enhances the...

  • Phd - Department of Physiology

    1 week geleden

    Amsterdam Zuid, Nederland Amsterdam UMC Voltijd

    About the project:Prof P.L. Hordijk - Innovative modelling of the human microcirculation by merging vascular cell biology with computational scienceIn this project, we will study the molecular basis of endothelial integrity in the context of acute and chronic inflammatory responses. Recent work from our group showed that a rapid cycle of protein synthesis...

  • Drie Getalenteerde Phd Studenten

    1 week geleden

    Amsterdam, Noord-Holland, Nederland CWI Voltijd

    Centrum Wiskunde & Informatica (CWI) heeft vacatures binnen de onderzoeksgroep Stochastics voor**Drie getalenteerde PhD studenten (m/v/x),**over het onderwerp "Machine Learning voor de bestrijding van cyberdreiging".**Functiebeschrijving**:De afgelopen jaren is cyberdreiging dramatisch toegenomen met (potentieel) grote impact op het goed functioneren van...

  • Phd-student: Physical Learning Machines

    3 weken geleden

    Amsterdam Oost, Nederland AMOLF Voltijd

    **PhD-student: Physical learning machines**: **Work Activities**: The Learning Machines group seeks motivated PhD students to join our team working on learning in physical systems. What are learning machines? Imagine your favorite artificial intelligence \ machine learning system figuring out how to solve a task, possibly classifying images of cats and dogs;...

  • Phd-student: Nanophotonics and Quantum Physics with

    2 weken geleden

    Amsterdam Oost, Nederland AMOLF Voltijd

    **Work Activities**: Did you know high-energy electrons can serve as efficient sources of optical excitation of matter? Our group has developed cathodoluminescence microscopy, in which we use 1-30 keV electrons in a scanning electron microscope (SEM) to excite nanomaterials. The oscillating electric field carried by the electron serves as a broadband (0-30...