Postdoc Mechanobiology of Extracellular Matrix

Postdoc Mechanobiology of Extracellular Matrix Materials with Designer Cell-Matrix Interactions-
**_Postdoc mechanobiology of designer extracellular matrix materials with programmable cell-matrix interactions_**

Job description

Biomaterials are widely used as scaffolds for cell culture in regenerative medicine, organ-on-chip human disease models, and cell-based meat production. However, they are currently mostly based on structural proteins sourced from animal tissues. Animal-derived products are unsustainable and difficult to customize. The goal of this project is to develop recombinant protein-based biomaterials capable of guiding cell functions by emulating the extracellular matrix of tissues.

Your role in this project will be to design the mechanobiological properties of the tissue-mimicking biopolymer networks via programmable cell-matrix interactions. Biomaterials should ideally permit independent control of their physical and biochemical properties because cells sense and respond to both cues. This has proven challenging with natural proteins since increasing the stiffness via the protein concentration also changes the ligand density. To address this challenge, you will explore composite materials of recombinant collagen and elastin-like polypeptides (ELPs). ELPs have no intrinsic bioactivity and can thus be made selectively bioactive by incorporating selected peptide motifs. You will explore how to program the physical and biochemical properties of these materials to steer cell differentiation and cell functions with a focus on endothelial cells and fibroblasts, relevant for soft tissue repair, and on pluripotent stem cells, relevant for cell-based meat or cell therapies.

**Requirements**:
Applicants must:

- hold a PhD, or approach its completion, in biophysics or a closely related discipline;
- have experience with biophysics and/or mechanobiology, optical imaging, mammalian cell culture and analysis skills;
- have excellent written and spoken English skills;
- thrive in an international, ambitious, multidisciplinary, and highly collaborative environment.

Conditions of employment

Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities. The TU Delft offers a customisable compensation package, discounts on health insurance, and a monthly work costs contribution. Flexible work schedules can be arranged.

From 1 September next, a salary increase of 3.7% applies due to a Collective Agreement amendment, followed by an additional 1% increase on 1 January 2025. In addition, most employees employed on 1 September 2024 will receive a one-off payment of €300 gross based on full-time employment.

For international applicants, TU Delft has the Coming to Delft Service. This service provides information for new international employees to help you prepare the relocation and to settle in the Netherlands. The Coming to Delft Service offers a Dual Career Programme for partners and they organise events to expand your (social) network.

TU Delft (Delft University of Technology)

Delft University of Technology is built on strong foundations. As creators of the world-famous Dutch waterworks and pioneers in biotech, TU Delft is a top international university combining science, engineering and design. It delivers world class results in education, research and innovation to address challenges in the areas of energy, climate, mobility, health and digital society. For generations, our engineers have proven to be entrepreneurial problem-solvers, both in business and in a social context.

Challenge. Change. Impact

Faculty Applied Sciences

With more than 1,100 employees, including 150 pioneering principal investigators, as well as a population of about 3,600 passionate students, the Faculty of Applied Sciences is an inspiring scientific ecosystem. Focusing on key enabling technologies, such as quantum
- and nanotechnology, photonics, biotechnology, synthetic biology and materials for energy storage and conversion, our faculty aims to provide solutions to important problems of the 21st century. To that end, we educate innovative students in broad Bachelor's and specialist Master's programmes with a strong research component. Our scientists conduct ground-breaking fundamental and applied research in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Engineering Physics. We are also training the next generation of high school teachers.

Click here to go to the website of the Faculty of Applied Sciences.

Additional information

Application procedure
- Cover letter;
- Detailed CV;

Please note:

- A pre-employment screening can be part of the selection procedure.
- Please do not contact us for unsolicited services.
- FACULTY/DEPARTMENT***

**Faculty of Applied Sciences**:

- JOB TYPE***

**Postdoc Positions**:

- SCIENTIFIC FIELD***

**Natural sciences**:

- HOURS PER WEEK***

**38**:

- SALARY***

**€ 3.22