Phd Position in Molecular Control of
2 weken geleden
The immune system helps plants resist pathogen infections and has been well studied. However, it becomes increasingly clear that enhancing defense comes at a cost, as plants slow down growth even if the infection is successfully combatted. In this project, you will investigate the poorly understood process of how plants control their growth during and after an immune response. You will capitalise on the available extensive lettuce gene expression and high-throughput phenotyping datasets.
**Your job**:
Current projections show that the incidence of diseases on crops will increase in the coming decades, and thus, conceptually new strategies, beyond strengthening the immune system, are needed to ensure the resilience of future crops. It turns out that plants slow down their growth during and after an immune response regardless of the disease intensity. However, how these growth processes are regulated in plants is unclear. In this curiosity-driven PhD project, you will uncover the genetic and molecular basis of plant growth during and after an immune response. With this knowledge, one could develop approaches that reduce this tradeoff in crop growth. You will primarily work with lettuce (_Lactuca sativa_), but conservation of the deduced concepts can be investigated in other plant species, such as _Arabidopsis thaliana_.
Your project will capitalise on two types of datasets generated during the LettuceKnow programme. The first dataset includes large and dense time-course RNAseq experiments, where we activated the lettuce immune system and tracked the transcriptome changes over several hours. The second dataset includes high-throughput digital phenotyping data for the growth of ~180 lettuce varieties in the presence of defense hormones and after their removal (the recovery phase). This dataset was obtained with the Netherlands Plant Ecophenotyping Center (NPEC).
In the first phase of the project, you will utilise bioinformatics, genome-wide association mapping (GWAS), and machine learning techniques to identify new players of plant growth during and after an immune response. You will validate the genetic leads, such as transcription factors (TFs), identified in our earlier research. In the second phase of the project, you will work on the functional validation and characterization of the identified regulators of immunity-conditioned growth (e.g., TFs) using CRISPR-Cas gene editing and alteration of gene expression in lettuce and Arabidopsis. For selected targets, you will use quantitative proteomics and chromatin-protein interaction assays to gain insights into the activity of protein complexes driving growth during and after an immune response. Similarly, high-throughput digital phenotyping of mutants and overexpression lines in NPEC can be used to investigate their impact on inferred regulatory pathways.
We currently have another PhD position on growth-immunity tradeoffs available in Dmitry Lapin’s team. For more information about this position, check out our website.
**Your qualities**:
We are looking for a collaborative, enthusiastic, and curiosity-driven colleague who:
- has a completed MSc degree or is about to get an MSc degree in molecular and/or computational biology;
- has an affinity to experimental (plant) biology research;
- has demonstrated skills in either or both computational and molecular biology research;
- wants to learn, deploy, or even develop new methods of computational and molecular biology research.
**Our offer**:
- We offer:
- a position for 4 years;
- a gross monthly salary between €2,770 and €3,539 in the case of full-time employment (salary scale P under the Collective Labour Agreement for Dutch Universities (CAO NU);
- 8% holiday pay and 8.3% year-end bonus;
- a pension scheme, partially paid parental leave and flexible terms of employment based on the CAO NU.
In addition to the terms of employment laid down in the CAO NU, Utrecht University has a number of schemes and facilities of its own for employees. This includes schemes facilitating professional development, leave schemes and schemes for sports and cultural activities, as well as discounts on software and other IT products. We also offer access to additional employee benefits through our Terms of Employment Options Model. In this way, we encourage our employees to continue to invest in their growth. For more information, please visit Working at Utrecht University.
**About us**:
A better future for everyone. This ambition motivates our scientists in executing their leading research and inspiring teaching. At Utrecht University, the various disciplines collaborate intensively towards major strategic themes. Our focus is on Dynamics of Youth, Institutions for Open Societies, Life Sciences and Pathways to Sustainability. Sharing science, shaping tomorrow.
At the Faculty of Science there are 6 departments to make a fundamental connection with: Biology, Chemistry, Information and Computing Sciences, Mathematics,
-
Phd Position in Molecular Control of
2 weken geleden
Utrecht, Nederland Universiteit Utrecht VoltijdThe immune system helps plants resist pathogen infections and has been well studied. However, it becomes increasingly clear that enhancing defense comes at a cost, as plants slow down growth even if the infection is successfully combatted. In this project, you will investigate how plants control their growth during and after an immune response. This research...
-
PhD Position: Molecular Mechanisms of Protein Biogenesis
1 maand geleden
Utrecht, Nederland Universiteit Utrecht VoltijdDissect protein synthesis, protein folding and chaperone function with cutting-edge single-molecule approaches! Are you curious about how cells produce functional proteins? Do you want to push the envelope of applying single-molecule techniques to complex macromolecular systems? Join our single-molecule lab to study co-translational folding and chaperone...
-
PhD Position: Molecular Mechanisms of Protein Biogenesis
3 weken geleden
Utrecht, Nederland Universiteit Utrecht VoltijdDissect protein synthesis, protein folding and chaperone function with cutting-edge single-molecule approaches! Are you curious about how cells produce functional proteins? Do you want to push the envelope of applying single-molecule techniques to complex macromolecular systems? Join our single-molecule lab to study co-translational folding and chaperone...
-
PhD Position: Molecular Mechanisms of Protein Biogenesis
6 dagen geleden
Utrecht, Utrecht, Nederland Universiteit Utrecht VoltijdDissect protein synthesis, protein folding and chaperone function with cutting-edge single-molecule approaches Are you curious about how cells produce functional proteins? Do you want to push the envelope of applying single-molecule techniques to complex macromolecular systems? Join our single-molecule lab to study co-translational folding and chaperone...
-
Phd Position: Molecular Mechanisms of Protein
4 weken geleden
Utrecht, Nederland Universiteit Utrecht Voltijd**Your job**: We are working at the interface of biochemistry, molecular biology and biophysics to follow the journey of nascent proteins toward their functional structures as they emerge from the ribosome. These mechanistic studies pave the way for targeted interventions against protein misfolding and perturbed protein homeostasis which are important for a...
-
Utrecht, Nederland Universiteit Utrecht VoltijdThe immune system prevents pathogen invasion, but its overstimulation also affects plant growth. Join us to research the growth-defense trade-off.The immune system helps plants resist pathogen infections and has been well studied. However, it becomes increasingly clear that enhancing defense comes at a cost, as plants slow down growth even if the infection...
-
Utrecht, Nederland Universiteit Utrecht VoltijdThe immune system prevents pathogen invasion, but its overstimulation also affects plant growth. Join us to research the growth-defense trade-off.The immune system helps plants resist pathogen infections and has been well studied. However, it becomes increasingly clear that enhancing defense comes at a cost, as plants slow down growth even if the infection...
-
Utrecht, Utrecht, Nederland Universiteit Utrecht VoltijdThe immune system prevents pathogen invasion, but its overstimulation also affects plant growth. Join us to research the growth-defense trade-off.The immune system helps plants resist pathogen infections and has been well studied. However, it becomes increasingly clear that enhancing defense comes at a cost, as plants slow down growth even if the infection...
-
Phd Position: Molecular Mechanisms of Protein
5 dagen geleden
Utrecht, Utrecht, Nederland Universiteit Utrecht VoltijdYour job:We are working at the interface of biochemistry, molecular biology and biophysics to follow the journey of nascent proteins toward their functional structures as they emerge from the ribosome. These mechanistic studies pave the way for targeted interventions against protein misfolding and perturbed protein homeostasis which are important for a...
-
Utrecht, Nederland Universiteit Utrecht VoltijdThe plant immune system prevents pathogen invasion, but its overstimulation also affects plant growth. Join us to research molecular bases of this tradeoff.The immune system helps plants resist pathogen infections and has been well studied. However, it becomes increasingly clear that enhancing defense comes at a cost, as plants slow down growth even if the...
-
Utrecht, Nederland Universiteit Utrecht VoltijdThe plant immune system prevents pathogen invasion, but its overstimulation also affects plant growth. Join us to research molecular bases of this tradeoff.The immune system helps plants resist pathogen infections and has been well studied. However, it becomes increasingly clear that enhancing defense comes at a cost, as plants slow down growth even if the...
-
Utrecht, Utrecht, Nederland Universiteit Utrecht VoltijdThe plant immune system prevents pathogen invasion, but its overstimulation also affects plant growth. Join us to research molecular bases of this tradeoff.The immune system helps plants resist pathogen infections and has been well studied. However, it becomes increasingly clear that enhancing defense comes at a cost, as plants slow down growth even if the...
-
Technician Molecular Biology
6 dagen geleden
Utrecht, Utrecht, Nederland CheckMark Labrecruitment VoltijdBedrijfsomschrijvingOur client is Genmab, a biotechnology companyspecialized in the invention and development of new cancertherapies. This team supports the company with molecular biologytools and capabilities.FunctieomschrijvingAs a Technician Molecular Biology - Robotics you willperform molecular biological procedures using state-of-the-artliquid handling...
-
Technician Molecular Biology
6 dagen geleden
Utrecht, Utrecht, Nederland CheckMark Labrecruitment VoltijdBedrijfsomschrijvingOur client is Genmab, a biotechnology company specialized in the invention and development of new cancer therapies. This team supports the company with molecular biology tools and capabilities. FunctieomschrijvingAs a Technician Molecular Biology - Robotics you will perform molecular biological procedures using state-of-the-art liquid...
-
Postdoc Position: Molecular Mechanisms of Protein Biogenesis
1 maand geleden
Utrecht, Nederland Universiteit Utrecht VoltijdDissect protein synthesis, protein folding and chaperone function using cutting-edge single-molecule approaches! Are you curious about how cells produce functional proteins? Do you want to push the envelope of applying single-molecule techniques to complex macromolecular systems? Join our single-molecule lab to study co-translational folding and chaperone...
-
Postdoc Position: Molecular Mechanisms of Protein Biogenesis
3 weken geleden
Utrecht, Nederland Universiteit Utrecht VoltijdDissect protein synthesis, protein folding and chaperone function using cutting-edge single-molecule approaches! Are you curious about how cells produce functional proteins? Do you want to push the envelope of applying single-molecule techniques to complex macromolecular systems? Join our single-molecule lab to study co-translational folding and chaperone...
-
Phd in Neuroscience
4 weken geleden
Utrecht, Nederland UMC Utrecht VoltijdA PhD position for a period of 4 years on transcriptomically identifying distinct mouse neurons, and virally targeting them to modify behavior. Terms of employment in accordance with the CAO hospitals and UMCU salary scales.**Elke dag de zorg en de gezondheid van mensen verbeteren**Goede arbeidsvoorwaarden**Jezelf continu blijven ontwikkelen vinden we...
-
Phd in Neuroscience
1 dag geleden
Utrecht, Nederland UMC Utrecht VoltijdA PhD position for a period of 4 years on transcriptomically identifying distinct mouse neurons, and virally targeting them to modify behavior. Terms of employment in accordance with the CAO hospitals and UMCU salary scales.**Elke dag de zorg en de gezondheid van mensen verbeteren**Goede arbeidsvoorwaarden**Jezelf continu blijven ontwikkelen vinden we...
-
Technician Molecular Biology
2 maanden geleden
Utrecht, Nederland CheckMark Labrecruitment VoltijdBedrijfsomschrijvingOur client is Genmab, a biotechnology companyspecialized in the invention and development of new cancertherapies. This team supports the company with molecular biologytools and capabilities.FunctieomschrijvingAs a Technician Molecular Biology - Robotics you willperform molecular biological procedures using state-of-the-artliquid handling...
-
Technician Molecular Biology
3 weken geleden
Utrecht, Nederland CheckMark Labrecruitment VoltijdBedrijfsomschrijvingOur client is Genmab, a biotechnology companyspecialized in the invention and development of new cancertherapies. This team supports the company with molecular biologytools and capabilities.FunctieomschrijvingAs a Technician Molecular Biology - Robotics you willperform molecular biological procedures using state-of-the-artliquid handling...
