Phd Candidate 'uranu Project

2 maanden geleden

Nijmegen, Nederland Radboudumc Voltijd

In radionuclide therapy, a tumor-targeting vector is coupled to a therapeutic radionuclide to specifically irradiate tumor lesions from inside the body. This approach allows for the delivery of a high radiation absorbed dose to (metastasized) tumor lesions, while sparing healthy tissues. Despite the high potential of treatment, we currently do not know which type of radionuclide is most effective to kill cancer cells and what is its underlying mechanism of action.

Within this NWO funded consortium project UNRANU; **_we aim to unravel the radiobiological effects of radionuclide therapy and contribute to novel production methods for therapeutic radionuclides and patient-specific treatment._**

Your primary task will be to investigate the radiolabeling of tumor-targeting vectors like small molecules and microspheres. This will involve assessing the purity and quality of radionuclides, followed by the radiolabeling of small molecules and microspheres with various radionuclides for cancer treatment. You will also play a key role in developing vectors such as microspheres and small molecules, optimizing radiolabeling procedures, conducting quality control and stability tests, and managing radioisotope waste.

Effective collaboration is essential for this role, particularly with researchers involved in radioisotope production at Delft University of Technology, and those utilizing the radiolabeled vectors for internal radionuclide therapy in tumor cell and animal models at Radboudumc and Erasmus Medical Center.

**Tasks and responsibilities**:

- Investigate purity and quality of radionuclides.
- Radiolabel to several vectors like small-molecules, DTPA and microspheres with different radionuclides.
- Optimize vectors, including small molecules and various microspheres that can be labeled with radioisotopes or directly activated by neutrons in a research reactor, to improve radiolabeling efficiency. Additionally, investigate the radiolabeling percentage, shelf life of the formulation, stability in saline, blood, and serum, as well as waste products and other related factors.
- Investigate the stability, biodistribution of the vector-radionuclide constructs in biological models (cell-lines, organoids and mice tumor models)

**What we offer you**:
We offer you the opportunity to work within a large consortium and maintain close connections with various stakeholders from academia, industry, and society (e.g. TU Delft, ErasmucMC, NRG|PALLAS, AlfaRIM, HUB Organoids, MILabs, Quirem Medical, RTM, Siemens Healthineers, TerThera, URENCO, Von Gahlen, VSL RIVM, Wetenschapsknooppunt, patient organisations) to plan, discuss, and perform research in a stimulating environment. **You work in both the Department of Medical Imaging at Radboudumc in Nijmegen and the Department of Radiation Science and Technology at Delft University of Technology in Delft. **At Radboud university medical center, you build on your future. We are committed to providing the best care, education, and research. And we are true to our word, because we help you develop and seize opportunities and give you the room to grow. As an employer, we believe that employees should feel vital and happy at work in all stages of life. We are also committed to creating a healthy and safe working environment. Our employment conditions contribute to that. What we offer:

- Upon commencement of employment, you will start at scale 10A, step 0 (€ 3.017 based on a full-time appointment). Over a maximum period of 4 years, you will progress to scale 10A, step 3 (€3.824 based on a full-time appointment). You will also receive an 8% holiday allowance, an 8.3% end-of-year bonus, and a 47% to 72% bonus for working unsocial hours.
- 172 vacation hours per year based on a 36-hour working week. (As of 1 January 2025, you will receive 176 vacation hours.)
- An Employment Conditions Selection Model, allowing you to use part of your employment conditions to your choosing. For example, you can use your gross salary to purchase additional vacation hours or hours for providing informal caregiving. Or, for example, you can use your gross end-of-year bonus to purchase a bicycle, so you pay less tax.
- Plenty of opportunities for personal development. You can take a variety of courses in our online learning environment.
- Your well-being and vitality are a priority. For example:

- Save time for work-life balance leave.
- A 40% discount on a sports membership of the Radboud Sports Center.
- Healthy Professionals program to help you manage your energy.
- Company Support Team and a personal coach if you are going through a life-changing event.
- Financially beneficial working less through a Generation Scheme as you approach state pension age.
- Support in achieving a good work-life balance at every stage of your life. Examples:

- Advice and courses on, for example, 'Millennial dilemmas' and 'Your Career After 57'.
- Activities at our own mindfulness center.
- Informal caregiving consultations

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