Postdoc Thyroid Lab

**Postdoc Thyroid Lab**:

- Closing date 16-09-2024- 36.01.24.TD1**Job description**:
Our group has obtained exciting results indicating a new metabolism pathway of thyroid hormones, potentially leading to a plethora of new hormones. This project aims to uncover a new form of thyroid hormone metabolism as a novel and physiological relevant pathway.

This postdoctoral training period enables you to learn the ins and outs of thyroid hormone signaling and to contribute an important next step to current knowledge in the field.

**Work environment**:
The Department of Internal Medicine is a large department with 9 research laboratories. Our mission is to pioneer innovation in research, education and care by bringing scientific discoveries to the patient.

The Thyroid lab has a longstanding interest in cellular thyroid hormone signaling. Our lab has identified key players in thyroid hormone signaling as well as discovered a number of disorders resulting from defects in cellular thyroid hormone regulation.

Our lab takes a truly translational approach, ranging from molecular studies to utilization of patient-derived iPSCs to model disorders and to testing therapeutic possibilities. After the discovery of MCT8 as a thyroid hormone transporter (2003), the identification of the first patients (2004), we obtained positive results in preclinical studies (2014) with a thyroid hormone analog (Triac) as a potential treatment for MCT8 deficiency. Following our investigator-initiated trial (2019), this molecule is currently taken to the market as a drug for this devastating disorder.

Although it has been recognized for decades that Triac is also endogenously produced, the pathways are unknown. This project aims to identify the biochemical cascade of thyroid hormone side chain metabolism and to determine its biological role. Different methods and technologies will be employed in this project, including LC-MS/MS, CRISPR-Cas and iPSC technologies.

**Qualifications and skills**:

- You are a curious and enthusiastic postdoc with experience in state-of-the-art biological chemistry. You are ready to take the next step in scientific discoveries.
- You have a PhD in Biochemistry, Biology or other related fields.
- You are a smart, creative and hard-working person with an interest in both fundamental and translational research.
- You have excellent oral and writing communication skills in (academic) English.

Do you like being part of a great team with a good atmosphere? And do you want to shape your project your own way? If yes, please apply

**Terms of employment**:

- You will receive a temporary position for 4 years (the initial contract willl be for 1 year with a realistic prospect of an extension for up to 3 years).
- The gross monthly salary amounts a maximum of € 5.504;
- (scale 10), depending on your level of education and relevant experience and based on a full-time working week of 36 hours.
- Excellent fringe benefits, such as a 13th month that is already paid out in November and an individual travel expense package.
- Pension insurance with ABP. We take care of approximately 2/3 of the monthly contribution.
- Special benefits, such as an incompany physiotherapist and bicycle repairer. And there is also a gym where you can work on your fitness after work.

**More information**:
No agencies please.