Clinical Phd Position: Investigation On

2 maanden geleden

Eindhoven, Nederland TU Eindhoven Voltijd

**Job description**:
Are you interested in working on pregnancy monitoring to improve pregnancy care? Do you enjoy to expand your clinical knowledge and skills also within a technical and industrial environment? This stimulating PhD position might be the right one for you

**Project description**

The ‘big four’ pregnancy pathologies (i.e., fetal growth restriction, premature birth, congenital disease, and asphyxia) have an incidence of 17-24%, resulting yearly in 2.6 million stillbirths and 303,000 maternal deaths globally. The detection of these pathologies is often late because the implementation of early detection strategies is currently limited. There is established evidence that pathologies and stillbirths are associated with an abnormal development of the fetal cardiovascular system (fCVS) and placenta as well as maladaptation to gestation of the maternal cardiovascular system (mCVS) and the uterus. However, how these abnormal mechanisms result in pregnancy related cardiovascular complications has not been fully investigated. Nevertheless, the (patho)physiological interaction among these components might be the key to unravel the mechanisms responsible for pregnancy pathologies. The MAPPING project envisions a comprehensive investigation of the coupling between mCVS and fCVS, as mediated by the uterus and placenta, both in healthy and pathological pregnancies, with the final aim of improving pregnancy outcome. MAPPING will support the development of novel, diagnostic tools for timely diagnosis and, ultimately, prediction of pregnancy complications.

**Your tasks will be**:

- To assess the plausibility and quality of the results in terms of changes in coupling maps at different gestational ages and anomalies in pathological coupling maps from a physiological perspective, relying on existing knowledge of cardiovascular coupling and disorders.

**Academic and Research Environment**:
Eindhoven University of Technology (TU/e) is one of Europe’s top technological universities, situated in the heart of one of Europe’s largest high-tech innovation ecosystems. Research at TU/e is characterized by a combination of academic excellence and a strong real-world impact. This impact is pursued via close collaboration with high-tech industries and clinical partners.

The clinical study will be conducted at Máxima Medical Center, a large tertiary center for obstetric and neonatal care. Máxima MC has a longstanding collaboration with TU/e on pregnancy monitoring research.

Research related to this position will be carried out at the Biomedical Diagnostics (BM/d) lab of the Signal Processing Systems (SPS) group, which is part of the Electrical Engineering department. The BM/d lab, chaired by Prof. Mischi, has a strong track record in electrophysiological signal processing, physiological modelling, and quantitative analysis of biosignals, ranging from ultrasound and MRI to electrophysiology. More specifically for this project, the BM/d lab has also a long tradition in pregnancy monitoring. For more information, see this link.

**Job requirements**:

- Master's degree in medicine or technical medicine.
- Strong interest in clinical research.
- Team player attitude, interested in collaborating with different teams.
- High motivation and creativity, precise and structured.
- Good communication and organization skills.
- Excellent English language skills (writing and presenting).

**Conditions of employment**:
A meaningful job in a dynamic and ambitious university, in an interdisciplinary setting and within an international network. You will work on a beautiful, green campus within walking distance of the central train station. In addition, we offer you:

- Full-time employment for four years, with an intermediate evaluation (go/no-go) after nine months. You will spend 10% of your employment on teaching tasks.
- Salary and benefits (such as a pension scheme, paid pregnancy and maternity leave, partially paid parental leave) in accordance with the _Collective Labour Agreement_ for Dutch Universities, scale P (min. €2,872 max. €3,670).
- A year-end bonus of 8.3% and annual vacation pay of 8%.
- High-quality training programs and other support to grow into a self-aware, autonomous scientific researcher. At TU/e we challenge you to take charge of your own learning process.
- An excellent technical infrastructure, on-campus children's day care and sports facilities.
- An allowance for commuting, working from home and internet costs.

**About us**

Eindhoven University of Technology is an internationally top-ranking university in the Netherlands that combines scientific curiosity with a hands-on attitude. Our spirit of collaboration translates into an open culture and a top-five position in collaborating with advanced industries. Fundamental knowledge enables us to design solutions for the highly complex problems of today and tomorrow.

**Information**

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