Intern, Discovery Preparation and Humanization

2 weken geleden

Utrecht, Nederland Genmab Voltijd

At Genmab, we’re committed to building extra[not]ordinary futures together, by developing antibody products and pioneering, knock-your-socks-off therapies that change the lives of patients and the future of cancer treatment and serious diseases. From our people who are caring, candid, and impact-driven to our business, which is innovative and rooted in science, we believe that being proudly unique, determined to be our best, and authentic is essential to fulfilling our purpose.

Role

Project

Antibodies are crucial tools in the development of targeted therapies, and Genmab’s innovative antibody formats continuously lead the way to new and innovative treatments for patients. Many therapeutic antibody targets naturally form multimers on the cell surface in order to induce efficient and selective signaling. Detailed characterization of the binding and signaling behavior of the antibody to its target using in vitro assays is crucial to increase understanding and drive successful development of new products. It is important to understand the behavior of protein targets that have the potential to form dimers or oligomers within the conditions of these in vitro experiments, and to study the effect they have on the outcome of the characterization and screening studies.

In this internship, the focus will be on producing and characterizing oligomeric protein targets. Specifically, the intern will work with engineered protein targets that exist in specific oligomeric states, helping to dissect the impact of these states on antibody binding affinity and behavior using biophysical methods including Surface Plasmon Resonance (SPR) and Isothermal Titration Calorimetry (ITC). The project will be carried out in close collaboration with the Functional Characterization & Bioassays team in the CMC department, providing the intern with hands-on experience in protein design, production, and biophysical characterization.

By developing oligomeric protein targets and benchmarking their in vitro behavior, you will contribute to a better understanding of how the oligomeric state of a target influences antibody binding. This knowledge is expected to improve the screening and characterization of therapeutic antibodies and enable more efficient mapping of antibody binding characteristics.

**Responsibilities**:

- You design proteins that constitutively exist in a certain oligomeric state using protein engineering techniques and you support successful production and purification of these constructs.
- You develop binding assays and perform affinity measurements using SPR and ITC.
- You critically assess the quality and outcome of binding assays and provide the team with detailed molecular hypotheses underpinning the observed behavior.
- You communicate results clearly to the rest of the team or department.
- You work in the lab in an organized manner and strive to consistently generate good results.
- You document results in an organized and concise manner in the Electronic Lab Notebook (ELN).

**Requirements**:

- You are currently connected to a Dutch university and pursuing a Master's degree in a relevant area, e.g. biomedical sciences or biomedical engineering, molecular biology, life sciences, immunology, or similar.
- Knowledge and understanding of protein engineering is a pre.
- Knowledge and understanding of biophysical techniques such as ITC, SPR and BLI is a pre.
- Ability to work successfully in a fast-paced environment in collaboration with a diverse group of scientists and other stakeholders.
- Ability to be proactive, enthusiastic and goal oriented.
- Strong communication skills in English, both oral and written.

About You
- You are passionate about our purpose and genuinely care about our mission to transform the lives of patients through innovative cancer treatment
- You bring rigor and excellence to all that you do. You are a fierce believer in our rooted-in-science approach to problem-solving
- You are a generous collaborator who can work in teams with diverse backgrounds
- You are determined to do and be your best and take pride in enabling the best work of others on the team
- You are not afraid to grapple with the unknown and be innovative
- You have experience working in a fast-growing, dynamic company (or a strong desire to)
- You work hard and are not afraid to have a little fun while you do so

Locations

Genmab leverages the effectiveness of an agile working environment, when possible, for the betterment of employee work-life balance. Our offices are designed as open, community-based spaces that work to connect employees while being immersed in our state-of-the-art laboratories. Whether you’re in one of our collaboratively designed office spaces or working remotely, we thrive on connecting with each other to innovate.

About Genmab

Genmab is an international biotechnology company with a core purpose guiding its unstoppable team to strive towards improving the lives of patients through innovative and

  • Scientific Researcher, Discovery Preparation and Humanization

    1 week geleden

    Utrecht, Utrecht, Nederland Genmab Voltijd

    Intern/Graduation Project: Discovery Preparation & HumanizationIn this internship, you'll work with our team in Utrecht to conduct scientific research on Genmab's innovative antibody products and formats. Your goal will be to improve our understanding of how antibodies interact with their targets, which will help us develop more effective treatments for...

  • Intern, Format Discovery

    6 maanden geleden

    Utrecht, Nederland Genmab Voltijd

    At Genmab, we’re committed to building extra[not]ordinary futures together, by developing antibody products and pioneering, knock-your-socks-off therapies that change the lives of patients and the future of cancer treatment and serious diseases. From our people who are caring, candid, and impact-driven to our business, which is innovative and rooted in...

  • Intern, Format Discovery

    5 maanden geleden

    Utrecht, Nederland Genmab Voltijd

    At Genmab, we’re committed to building extra[not]ordinary futures together, by developing antibody products and pioneering, knock-your-socks-off therapies that change the lives of patients and the future of cancer treatment and serious diseases. From our people who are caring, candid, and impact-driven to our business, which is innovative and rooted in...

  • Intern, Format Discovery

    5 maanden geleden

    Utrecht, Nederland Genmab Voltijd

    At Genmab, we’re committed to building extra[not]ordinary futures together, by developing antibody products and pioneering, knock-your-socks-off therapies that change the lives of patients and the future of cancer treatment and serious diseases. From our people who are caring, candid, and impact-driven to our business, which is innovative and rooted in...

  • Scientist - Format Discovery Internship

    1 week geleden

    Utrecht, Utrecht, Nederland Genmab Voltijd

    At Genmab, our vision is to build a better future for patients by developing innovative cancer treatment and serious disease therapies. We embody a culture of collaboration, innovation, and excellence, where every individual contributes to our mission. As a Format Discovery intern, you will be an integral part of our team, working closely with research...

  • Product Discovery Intern

    2 weken geleden

    Utrecht, Utrecht, Nederland Genmab Voltijd

    About the RoleGenmab is seeking an Intern to join the Product Discovery (PD) department. As an Intern, you will have the opportunity to explore and exploit the complement system in oncology. The PD team leverages proprietary Genmab antibody formats and technologies to imagine, create and characterize the next generation of antibody therapeutics to treat...

  • Research Scientist

    3 weken geleden

    Utrecht, Utrecht, Nederland Genmab Voltijd

    About the RoleAt Genmab, we're committed to building extraordinary futures together. As a Research Scientist - Antibody Discovery, you will be working closely with our Research Associates on projects in the Format Discovery team to support antibody knowledge generation within the Antibody Research & Technologies department. This role is ideal for students or...

  • Research Associate

    2 weken geleden

    Utrecht, Utrecht, Nederland Genmab Voltijd

    At Genmab, we're committed to building extraordinary futures together, by developing innovative antibody products and pioneering therapies that change the lives of patients and the future of cancer treatment and serious diseases. Our team is driven by a passion for science and a commitment to excellence, and we're looking for a talented individual to join...

  • Research Scientist Intern

    4 weken geleden

    Utrecht, Utrecht, Nederland Genmab Voltijd

    About the RoleAt Genmab, we're dedicated to creating a brighter future for patients through innovative cancer treatment and serious disease therapies. Our team is passionate about developing antibody products and pioneering therapies that make a real difference.Key ResponsibilitiesSupport research associates in the Format Discovery team to explore research...

  • Research Scientist Intern

    4 weken geleden

    Utrecht, Utrecht, Nederland Genmab Voltijd

    About the RoleAt Genmab, we're dedicated to creating a brighter future for patients through innovative cancer treatment and serious disease therapies. Our team is passionate about developing antibody products and pioneering new therapies that make a real difference in people's lives.Key ResponsibilitiesSupport research associates in the Format Discovery team...

  • Research Scientist Intern

    3 weken geleden

    Utrecht, Utrecht, Nederland Genmab Voltijd

    About the RoleAt Genmab, we're dedicated to creating a brighter future for patients through innovative cancer treatment and serious disease therapies. Our team is passionate about developing antibody products and pioneering new therapies that make a real difference in people's lives.Key ResponsibilitiesSupport research associates in the Format Discovery team...

  • Molecular Biologist Intern

    5 dagen geleden

    Utrecht, Utrecht, Nederland Genmab Voltijd

    Internship OpportunityWe're committed to building extraordinary futures together, by developing antibody products and pioneering therapies that change lives of patients and the future of cancer treatment and serious diseases.Position OverviewOur Cell and Molecular Sciences team is seeking an intern to assist in the design and execution of experiments using...

  • Biotechnology Research Assistant

    1 week geleden

    Utrecht, Utrecht, Nederland Genmab Voltijd

    About the RoleThe Biotechnology Research Assistant will work closely with research associates on a project in the Format Discovery team to aid in the exploration of a specific research question. This role involves supporting the development of antibody knowledge generation within ART through the design and performance of several...

  • Biotechnology Research Assistant

    3 dagen geleden

    Utrecht, Utrecht, Nederland Genmab Voltijd

    At Genmab, our mission is to transform the lives of patients through innovative cancer treatment and serious diseases. We believe in a culture of collaboration, where everyone contributes to our purpose.RoleThe intern will work closely with research associates on one of the projects in the Format Discovery team to support antibody knowledge generation within...

  • Intern, Format Development

    4 weken geleden

    Utrecht, Nederland Genmab Voltijd

    At Genmab, we’re committed to building extra[not]ordinary futures together, by developing antibody products and pioneering, knock-your-socks-off therapies that change the lives of patients and the future of cancer treatment and serious diseases. From our people who are caring, candid, and impact-driven to our business, which is innovative and rooted in...

  • Intern, Format Development

    4 weken geleden

    Utrecht, Nederland Genmab Voltijd

    At Genmab, we’re committed to building extra[not]ordinary futures together, by developing antibody products and pioneering, knock-your-socks-off therapies that change the lives of patients and the future of cancer treatment and serious diseases. From our people who are caring, candid, and impact-driven to our business, which is innovative and rooted in...

  • Biotech Research Assistant

    3 weken geleden

    Utrecht, Utrecht, Nederland Genmab Voltijd

    At Genmab, we're dedicated to creating innovative solutions for cancer treatment and serious diseases. Our team is passionate about developing antibody products that change lives.RoleThe intern will work closely with research associates on a project in the Format Discovery team to support antibody knowledge generation within ART.ResponsibilitiesThe intern...

  • Intern, Product Discovery, I&i

    2 dagen geleden

    Utrecht, Nederland Genmab Voltijd

    At Genmab, we’re committed to building extra[not]ordinary futures together, by developing antibody products and pioneering, knock-your-socks-off therapies that change the lives of patients and the future of cancer treatment and serious diseases. From our people who are caring, candid, and impact-driven to our business, which is innovative and rooted in...

  • Intern, Cell

    1 week geleden

    Utrecht, Nederland Genmab Voltijd

    At Genmab, we’re committed to building extra[not]ordinary futures together, by developing antibody products and pioneering, knock-your-socks-off therapies that change the lives of patients and the future of cancer treatment and serious diseases. From our people who are caring, candid, and impact-driven to our business, which is innovative and rooted in...

  • Protein and Cell Supply Chain Director

    3 weken geleden

    Utrecht, Utrecht, Nederland Genmab Voltijd

    About the RoleWe are seeking a highly experienced and skilled Director of Protein and Cell Supply to lead our Antibody Research Materials Department. As a key member of the Discovery functional organization, you will play a critical role in driving Genmab's discovery pipeline by managing the teams responsible for providing essential research materials for...