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Postdoctoral Researcher in Serial Crystallography

2 maanden geleden


Amsterdam, Noord-Holland, Nederland VU Amsterdam Voltijd

Position Overview

A postdoctoral research opportunity is available focusing on Serial Crystallography (SX), a cutting-edge technique for visualizing macromolecular interactions with light. This role involves conducting 'pump–probe' experiments, where a brief UV-Visible laser pulse excites chromophores in the target molecule, followed by an X-ray pulse that probes the resultant state at a defined delay. The objective is to correlate light-induced X-ray crystallographic electron densities with various reactions and excited-state phenomena. This research will delve into light-inducible proteins that play crucial roles in photosynthesis and photobiology, complemented by time-resolved spectroscopy techniques.

Key Responsibilities

  • Develop and implement a data processing pipeline for crystallographic datasets.
  • Engage actively in the group's time-resolved serial crystallography experiments.
  • Contribute to the organization and execution of serial crystallography experiments.
  • Conduct SX experiments with a strong focus on data analysis.
  • Explore the photo-regulatory and molecular responses of various proteins to light exposure.
  • Integrate SX findings with time-resolved spectroscopy observations.

Candidate Profile

  • PhD in physics, physical chemistry, biophysics, biochemistry, or related fields.
  • Experience and knowledge in structural biology and serial crystallography, particularly in large data analysis.
  • Proficiency in CrystFEL or DIALS data processing software is highly advantageous.
  • Familiarity with Phenix and CCP4 software.
  • Strong programming skills in Python or a similar language.
  • Enthusiasm for working in a multidisciplinary research environment.
  • Fluency in English is essential.

At VU Amsterdam, we are committed to fostering an inclusive community that values diversity in all its forms. We recognize that each individual brings a unique set of skills and experiences, and we encourage applications from all qualified candidates, even if they do not meet every requirement listed.

What We Offer

This position provides a stimulating environment within a socially responsible organization. At VU Amsterdam, your contributions will enhance education, research, and community service aimed at improving the world. In return for your commitment, we offer:

  • A competitive salary starting at €3,000 (gross per month, full-time), based on the UFO profile Researcher 4, with the exact amount dependent on your qualifications and experience.
  • A contract for a minimum of 0.8 FTE, initially for one year, with potential for extension.

Additional benefits include:

  • A full-time position entitles you to a holiday leave of hours per year, with extra leave for those working 40 hours weekly.
  • 8% holiday allowance and an annual end-of-year bonus of 8.3%.
  • Discounts on cultural events and courses at the Griffioen Cultural Center.
  • Support for commuting expenses.
  • Discounts on collective insurance plans (healthcare and car insurance).