Phd Candidate: Phd Candidate: Chemical Biology of Glycopeptide-based Probes
2 dagen geleden
Vacancy number
16017
Job type
PhD positions
Hours (in fte)
1,0
External/ internal
Internal, External
Location
Leiden
Contract type
Temporary
Placed on
25 September 2025
Closing date
9 October 2025 14 more days to apply
We are seeking a highly motivated PhD student to join the Bioorganic Synthesis group on a project which aims to develop innovative chemical tools to study mucin degradation. Bacterial enzymes that degrade host mucins play key roles in both health and disease. However, despite their importance in gut colonization and pathogenesis, mucin-degrading enzymes remain poorly understood due to a lack of suitable chemical tools. This project will focus on the implementation of chemical tools to detect, characterize, and modulate mucin-hydrolase activity in bacterial secretomes and patient samples.
**Work and Profile**
The successful applicant will be responsible for the design and synthesis of new chemical probes targeting mucin-degrading proteins.
Selection Criteria
- M.Sc. degree in biochemistry, structural biology, chemical biology or equivalent;
- Proven experience with protein expression and purification;
- Experience with assay design, inhibitor assessment, and structure determination is appreciated;
- Interest in chemical glycobiology;
- Proficient in English;
- Excellent communication skills;
- Ability to work independently and as a team player in a multidisciplinary environment;
**Description of organisation and terms of employment**
The position starts by January 1st 2026. We offer a position for 1 year and upon satisfactory performance to be extended for 3 more years. You will be appointed in accordance with the Collective Labour Agreement for Dutch Universities. The salary ranges from € 3.059;
- to € 3.881;
- gross per month (pay scale P).
**Faculty**
The Faculty of Science at Leiden University is a world-class faculty where staff and students work together in a dynamic international environment. It is a faculty where personal and academic development are top priorities. Our people are committed to expand fundamental knowledge by curiosity and to look beyond the borders of their own discipline; their aim is to benefit science, and to make a contribution to addressing the major societal challenges of the future.
The research carried out at the Faculty of Science is very diverse, ranging from mathematics, information science, astronomy, physics, chemistry and bio-pharmaceutical sciences to biology and environmental sciences. The research activities are organized in eight institutes. These institutes offer eight bachelors’ and twelve master’s programmes. The faculty has grown strongly in recent years and now has more than 2,300 staff and over 5,000 students. We are located at the heart of Leiden’s Bio Science Park, one of Europe’s biggest science parks, where university and business life come together.
**University**
Leiden University is one of Europe’s leading international research universities.
Thanks to its committed and inspired employees, the university enjoys a leading role in academic research and education. Leiden also scores very well every year in prominent rankings. This means that, to maintain our position, the bar is set very high. Regardless of the work you do at our university, you are always encouraged to broaden your horizons, develop your talents and reach your full potential. Will you become our newest colleague?
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Leiden, Nederland Universiteit Leiden VoltijdVacancy number 16016 Job type PhD positions Hours (in fte) 1,0 External/ internal Internal, External Location Leiden Contract type Temporary Placed on 25 September 2025 Closing date 9 October 2025 14 more days to apply **Work and Profile** The successful applicant will be responsible for the design and synthesis of new chemical probes...
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