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Phd Candidate in Structural Virology and Antiviral Development
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**Your job**:
Noroviruses are the leading cause of non-bacterial gastroenteritis outbreaks worldwide. Despite their substantial global health impact, our molecular understanding of Norovirus replication remains incomplete. Critically, no approved direct-acting antivirals are currently available to protect high-risk populations from severe or life-threatening disease.
As a key step toward addressing this gap, our team recently published a preprint presenting the first high-resolution**structure of the Norovirus NS3 protein, revealing a putative transmembrane RNA translocase:
Haas et al. (2025) - _Integrative Structure of Norovirus NS3 Suggests a Role in RNA Transport_
**Key Responsibilities**
- Express and purify recombinant Norovirus NS3 complexes for biochemical and structural studies
- Design and carry out single-particle cryo-EM experiments to visualize NS3 complexes at high resolution
- Support antiviral compound screening and contribute to the structural characterization of NS3-inhibitor complexes
- Process and analyze cryo-EM data using established computational pipelines and structural modeling tools
- Apply, or develop expertise in, in situ cryo-electron tomography to investigate NS3 function and viral replication within infected cells
- Collaborate closely with molecular virologists, structural biologists, and computational scientists within an interdisciplinary team
- Supervise and mentor Bachelor’s and Master’s students involved in related research projects
- Communicate findings through peer-reviewed publications and presentations at international scientific conferences
**Your qualities**:
- A Master’s degree in Biochemistry, Virology, Molecular Biology, Structural Biology, or a related discipline.
- Hands-on experience with protein expression and purification, ideally involving recombinant membrane or viral proteins.
- A strong interest in virus-host interactions, viral replication mechanisms, and antiviral drug development.
- Experience with, or a clear motivation to learn, cryo-EM data collection, image processing, and 3D structural analysis.
- Prior experience with cryo-EM single-particle analysis (SPA) and/or cryo-electron tomography (cryo-ET) is a strong advantage, but not a requirement.
- Background knowledge in virology or protein biochemistry is beneficial.
- Ability to drive projects independently as well as part of a collaborative, interdisciplinary research team.
- Strong problem-solving skills, a well-organised approach to research, and excellent written and verbal communication abilities.
- Enthusiasm for mentoring undergraduate or Master’s students and contributing to a supportive research environment.
- Motivation to stay up to date with relevant literature in virology, structural biology, and antiviral development.
**Our offer**:
- A fully funded, four-year PhD position within an internationally recognized virology and structural biology laboratory.
- a working week of 36 - 40 hours and a gross monthly salary between € 2.901 and €3.707 in the case of full-time employment (salary scale P under the Collective Labour Agreement for Dutch Universities (CAO NU));
- 8% holiday pay and 8.3% year-end bonus;
- a pension scheme, partially paid parental leave and flexible terms of employment based on the CAO NU.
In addition to the terms of employment laid down in the CAO NU, Utrecht University has a number of schemes and facilities of its own for employees. This includes schemes facilitating professional development, leave schemes and schemes for sports and cultural activities, as well as discounts on software and other IT products. We also offer access to additional employee benefits through our Terms of Employment Options Model. In this way, we encourage our employees to continue to invest in their growth. For more information, please visit Working at Utrecht University.
**About us**:
A better future for everyone. This ambition motivates our scientists in executing their leading research and inspiring teaching. At Utrecht University, the various disciplines collaborate intensively towards major strategic themes. Our focus is on Dynamics of Youth, Institutions for Open Societies, Life Sciences and Pathways to Sustainability. Sharing science, shaping tomorrow.
The Virology Section of the Department of Biomolecular Health Sciences of the Faculty of Veterinary Medicine studies the interaction between viruses and their hosts at the molecular/cell biological level as well as at the level of the organism. Ultimately, we strive to translate obtained knowledge into the development of novel vaccines, antiviral therapies, and diagnostic tools.
You will be supervised and coached in your development by dr. Daniel Hurdiss. You will join our large team of about 30 researchers that focuses on the molecular aspects of infection of corona-, influenza
**More information**:
As Utrecht University, we want to be a home for everyone. We value staff with diverse backgrounds, perspectives and identitie
