Phd Student

7 dagen geleden

Groningen, Nederland UMCG Voltijd

**Functiebeschrijving**:
The exposome is concept that aims to capture the combined cumulative exposure of environmental stressors to individuals throughout their lifespan. It is estimated that 70% of all chronic disease burden are determined by exposome, with only 30% are dependent on individual’s genetic makeup. This provides an opportunity to estimate the risk for diseases by knowing the individuals’ exposures, and to prevent that by modifying person’s individual exposome.

Exposome-NL is a Dutch consortium of over fifty scientists from different disciplines, universities and medical centres. Within this consortium, UMCG team focuses on studying the coherence between exposome and internal human environment, such as gut microbiome and metabolites. We build the research upon Lifelines biobank, the large prospective cohort that comprises more than 150,000 citizens of the Northern Netherlands.

We aim to identify the effects of cumulative environmental stressors (e.g. pollutant chemicals, air pollution, noise pollution, socio-economic and demographic neighbourhood, and many other exposome factors) on human gut microbiome, metabolites circulating in body fluids, and other omics data. This work will mainly focus on the analysis of longitudinal microbiome datasets in large population cohorts. We combine the state-of-art exposome methodology, omics data expertise, and advanced statistical methodology to evaluate the individuals’ exposures to certain exposome parameters, and further build a network of exposome-omics interactions.

**Some papers describing the concepts and methods of exposome research in relation to human health**

**Papers describing the microbiome and exposome work of our team**:
**Wat vragen wij**:
**Required Expertise**
- Master’s degree or equivalent, preferably with a focus on of the following topics: Bioinformatics, Statistics, Microbiology, Chemistry, Environmental sciences
- A collaborative spirit to work effectively within an interdisciplinary team
- Excellent organizational and networking skills
- Strong communication skills, both written and verbal

**Additional experience in the following areas is highly desirable**
- Knowledge on the human microbiome and metabolomics
- Knowledge and experience on exposome
- Experience handling large databases
- Knowledge of developing and debugging in R or Python

**Wat bieden wij**:

- gross per month in the first year and a maximum of € 3.824;
- gross per month (scale PRO) in the final (4th) year, based on a full-time appointment. In addition, the UMCG will offer you 8% holiday pay, and 8.3% end-of-year bonus. The conditions of employment comply with the Collective Labour Agreement for Medical Centres (CAO-UMC).

**Meer informatie**: Neem voor meer informatie contact op met:
Aleksandr Kurilshchikov, telefoonnummer 06 3950 9661
Alexandra Zhernakova, telefoonnummer 06 2166 1813
**Solliciteren**:

- confirmation with further information.

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