Phd Position Off-gas Spectroscopy for Physiology and Process Biomarker

**PhD Position Off-Gas Spectroscopy for Physiology and Process Biomarker**:
**Job description**:
Collaboration

Team

PhD project

The PhD position in this vacancy will focus on the discovery of novel volatile bioprocess biomarkers using (near) real-time novel spectroscopic off-gas techniques. In this project, you will have the opportunity to work with yeast bioreactors and explore the volatile compounds that are produced under different growth conditions. Process heterogeneity studies will be conducted at lab scale (scale-down) to identify novel bioprocess biomarkers. Orthogonal monitoring of physiology (e.g. transcriptomics and Raman) will be conducted in parallel with the aims of (1) better understanding cell physiology and (2) aiding biomarker identification. Finally, you will have the opportunity to test and validate biomarkers in different culture setups.

The PhD position co-supervised by dr. Vieira-Lara and dr. Klijn.

The group led by dr. Vieira-Lara is called Bioenergetics and Quantitative Biology. We investigate metabolic strategies of industrially relevant organisms from a quantitative perspective, combining fundamental research with applied approaches to enhance industrial processes.

The group led by dr. Klijn is called: Data-Driven Bioprocess Development group. In this group, we work on a wide variety of biotechnological processes (microbial, mammalian, ATMP) and the implementation of process analytical technology (such as FT-IR and Raman spectroscopy) for process development and process automated control purposes.

**Job requirements**:
Required educational backgroud
- A MSc degree in biotechnology, microbiology, (analytical) biochemistry or a closely related discipline

Recent experience or clearly supported motivation
- Recent experience with microbial fermentation or cell culture is considered a must
- Strong motivation for learning or recent experience with novel analytical technology is considered essential
- Recent experience in data analysis

Required technical skills or strong motivation to learn
- Bioreactor cultivation
- Analysis of large datasets
- Analytical techniques (HPLC, GC-MS, etc)
- Programming

Sought-after transferable skills
- Pro-active and problem solving mindset
- Excellent written and spoken English skills
- Ability to break-down and communicate complex research data
- Thrives in a fast-paced, multidisciplinary, and highly collaborative environment

**TU Delft (Delft University of Technology)**:
Delft University of Technology is built on strong foundations. As creators of the world-famous Dutch waterworks and pioneers in biotech, TU Delft is a top international university combining science, engineering and design. It delivers world class results in education, research and innovation to address challenges in the areas of energy, climate, mobility, health and digital society. For generations, our engineers have proven to be entrepreneurial problem-solvers, both in business and in a social context.

Challenge. Change. Impact

**Faculty Applied Sciences**:
With more than 1,100 employees, including 150 pioneering principal investigators, as well as a population of about 3,600 passionate students, the Faculty of Applied Sciences is an inspiring scientific ecosystem. Focusing on key enabling technologies, such as quantum
- and nanotechnology, photonics, biotechnology, synthetic biology and materials for energy storage and conversion, our faculty aims to provide solutions to important problems of the 21st century. To that end, we educate innovative students in broad Bachelor's and specialist Master's programmes with a strong research component. Our scientists conduct ground-breaking fundamental and applied research in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Engineering Physics. We are also training the next generation of high school teachers.

**Application procedure**
- 2-page CV, including contact details of 2 to 3 references
- 1-page motivation letter

**Please note**:

- A pre-employment screening can be part of the selection procedure.
- Please do not contact us for unsolicited services.
- Faculty/Department: Faculty of Applied Sciences
- Salary range: €2872 - €3670
- Hours per week: 36-40
- FTE: 1
- Submission is possible until: 3 Feb 2025
- ID job: 1751