Postdoc - Immunotherapy Target Discovery using Quantitative Membrane Proteomics

Over de functie
We are looking for a talented and eager postdoctoral researcher to drive a cutting‑edge, highly collaborative research project in the Voest & Lindeboom laboratories. Combining expertise from both labs, you will design novel immunotherapies by integrating innovative proteomics workflows with exciting culture techniques and genetic perturbation assays. You will have access to world-renowned expertise in quantitative proteomics and cancer drug development, while analyzing tumor models and primary patient material with the Orbitrap Astral mass spectrometer, a game‑changing machine that allows deep, quantitative proteome coverage at unprecedented speed and sensitivity.
You will

• Spearhead the development of an innovative proteomics lens to discover unique targets at the cell membrane for next-generation immunotherapies
• Apply these proteomics workflows (with technician support) on genetically modified tumor cell lines and organoids
• Collaborate with clinician‑scientists to make a real impact for patients
• Contribute to open, reproducible science and publish in high‑impact journals

*Why this postdoc?*

• Pioneering expertise: develop unique membrane proteomics tools and apply them in innovative manners to look at drug target discovery in a completely novel manner
• State‑of‑the‑art mass spectrometry: Learn and develop unique workflows with the Astral instrument to discover druggable protein dynamics
• Translational impact: Projects are embedded in ongoing, data‑rich clinical trials and preclinical programs, where experimentalists, computational scientists and clinicians closely collaborate to make a real impact for patients —you'll be supported across the full translational spectrum
• World‑class ecosystem: NKI offers leading research groups, core facilities and a vibrant international community in the heart of Amsterdam

*Why the Netherlands Cancer Institute?*
The Netherlands Cancer Institute (NKI) is a dynamic comprehensive cancer center accommodating over 55 research groups and many state-of-the-art core facilities, including imaging, cryo-EM, flow cytometry, proteomics, genomics and screening. At the Netherlands Cancer Institute, we have a shared goal: providing the best care for every patient and every type of cancer. Here, science and health care join forces towards innovation. We keep finding new ways to help people facing cancer on a global scale.

Wat breng je mee?

• PhD in quantitative proteomics, biochemistry or a closely related field;
• Hands‑on experience in proteomics and data analysis in the context of cancer;
• Hard working, highly motivated, curious, rigorous, team‑oriented;
• Strong publication record and excellent communication in English;
• Strong drive and inherent excitement to discover novel immunotherapeutic targets with quantitative proteomics.

*Your development opportunities and employment conditions*
The basic for your employment conditions is in accordance with the CLA Hospitals . You will receive from us:

• A fully funded 3‑year postdoctoral researcher position at our top institution, with a dynamic and highly international workforce and ample opportunities for personal development. Preferred start date: flexible (ideally soon);
• A contract for a period of three years, for 36 hours per week;
• A gross monthly salary between € 4.723,- and € 5.289,-, based on a 36-hour working week, in line with the postdoc scale (FWG55) and depending on your experience and status of PhD finalization;
• 144 holiday hours and 57 hours of Personal Life Budget, with full-time employment;
• Annual holiday pay of 8.33% and a fixed end-of-year bonus of 8.33%;
• A travel allowance of €0.23 per km;
• Free parking at the Netherlands Cancer Institute. And with our bicycle plan and discount on public transport we also make it attractive for you to leave the car at home;
• Personal mentorship from established PIs and senior scientists across both labs; clear milestones and career development plans;
• Access to best‑in‑class instruments, tumor models, and expert core facilities;
• An active staff association.

*Interested?
About
We are curious about your talent Will you be the one to make a difference in the world of cancer care and research? Apply now by using the
apply/solliciteer button*
at the top of the page Please attach your:

• CV, with publications, presentations and grades from your bachelor and master
• Cover letter, with a list of references

You can only upload two files to the submission system, so make sure to merge your transcript of grades and CV into one PDF. Incomplete applications will not be considered.

For further information about the position, please contact Joris van de Haar ( ) or Rik Lindeboom ( ).

Applications will be considered on a rolling basis until a suitable candidate is selected, but no later than the
19th of December 2025.