PhD position in molecular mechanisms of bleeding disorders

2 weken geleden

Rotterdam, Nederland Erasmus MC Voltijd

Job description

Von Willebrand Factor (VWF) plays a pivotal role in blood coagulation. VWF is secreted from endothelial cell Weibel-Palade bodies (WPBs), which is crucial for the response to vascular trauma. Dysfunctional WPB biogenesis and exocytosis are characteristic of bleeding disorders such as Von Willebrand disease. In this project, we aim to identify the organelle trafficking routes responsible for WPB formation and secretion.

This project is a collaboration between the research groups of Dr. Ruben Bierings (Department of Hematology, Erasmus MC, Rotterdam; ) and Prof. dr. Geert van den Bogaart (Department of Molecular Immunology, Faculty of Science and Engineering, University of Groningen (UG); ).
Two PhD positions are available, one at each institute.

The Erasmus MC candidate will conduct biochemical assays of WPB cargo secretion and optical assays of WPB exocytosis to determine changes in secretory competence and fusion mode due to altered SNARE sorting. Techniques include high content microscopy, proteomics, total internal reflection fluorescence (TIRF) microscopy, shRNA library screenings, and electron microscopy.

The UG candidate will utilize newly developed microscopy methods, including Förster resonance energy transfer-fluorescence lifetime imaging (FRET-FLIM), to map SNARE protein trafficking to WPBs. Techniques include FRET-FLIM microscopy, mammalian cell culturing, CRISPR, and molecular cloning.

The PhD candidates are expected to also spend research time at the other institute.

Work environment

The Department of Hematology at the Erasmus MC has pioneered innovative methods to understand the mechanisms of hematological disease on a molecular and cellular level. Combination of our patient cohort studies with cutting-edge molecular and cellular technologies on patient cells provides the unprecedented opportunity to perform innovative research on the biological mechanisms of disease and to make discoveries that impact the routine practice of patient care. The Erasmus MC is the largest treatment center for bleeding disorders in the Netherlands and our clinical and basic research revolves around understanding why patients bleed and how to improve their treatment.

In our lab () we use in vitro and ex vivo experimental studies on (patient-derived) endothelial cells with the objective to elucidate the mechanisms that regulate secretion of hemostatic proteins, in health and disease. 

Qualifications and skills

If you are ready to tackle the molecular cell biology of bleeding disorders, we encourage you to apply for this exciting PhD opportunity at Erasmus MC. You have the following qualifications:

A university MSc degree in molecular biology, biochemistry, cell biology, biomedical sciences or any other field that has affinity with basic and/or translational research. Excellent communication and presentation skills. Fluency in English (oral and written) is a prerequisite. Self-motivated, detail-oriented, and adept at both independent and collaborative work. Extensive hands-on practical laboratory experience is required, previous experience with mammalian cell biology and advanced microscopy approaches is an advantage. Willing to spend research time in Groningen.

Before you apply please check our .

Terms of employment

You will receive a temporary position for 4 years. The gross monthly salary is € 3.017,- in the 1st year and increases to € 3.824,- in the 4th year (scale OIO). Excellent fringe benefits, such as a 13th month that is already paid out in November and a individual travel expense package. Pension insurance with ABP. We take care of approximately 2/3 of the monthly contribution. Special benefits, such as a incompany physiotherapist and bicycle repairer. And there is also a gym where you can work on your fitness after work.

More information

A PhD training program is part of the agreement and the successful candidate will be enrolled in the Erasmus MC Graduate School ().
 
For more information about this position, please contact Dr. ir. Ruben Bierings, or .

If you are keen on this position and would like to apply, please do so by using the application form on our website. Please provide the following documents:

Motivation letter (max 1 page). Up-to-date CV (max 2 pages). List of grades for MSc degree. Contact details or letters of recommendation of two references.

Screening of applications will start as soon as applications are received and will continue until the position is filled.

No agencies please.

  • PhD student in Health Data Science

    2 weken geleden

    Rotterdam, Nederland Erasmus MC Voltijd

    Job description The department of Medical Informatics is looking for a PhD student to work on cutting-edge health AI and data science topics. This research will be performed in close collaboration with the Observational Health Data Sciences and Informatics (OHDSI) initiative, which is a global, multi-stakeholder, interdisciplinary collaborative to...

  • PhD candidate on novel antimicrobials for bacterial airway infections

    5 dagen geleden

    Rotterdam, Nederland Erasmus MC Voltijd

    Functie inhoud We offer a 4-year PhD position to test a new generation of antibiotics as a treatment for respiratory tract infections. This project is funded by ZonMw OPEN and unites the expertise of 4 academic research groups: Pediatric Infectious Diseases, Erasmus MC, Pharmacology University Utrecht; Microbiology University Utrecht and Chemical Biology and...

  • PhD candidate on novel antimicrobials for bacterial airway infections

    2 weken geleden

    Rotterdam, Nederland Erasmus MC Voltijd

    Functie inhoud We offer a 4-year PhD position to test a new generation of antibiotics as a treatment for respiratory tract infections. This project is funded by ZonMw OPEN and unites the expertise of 4 academic research groups: Pediatric Infectious Diseases, Erasmus MC, Pharmacology University Utrecht; Microbiology University Utrecht and Chemical...

  • PhD: implementation of digital tools and AI-driven scheduling in the OR

    2 weken geleden

    Rotterdam, Nederland Erasmus MC Voltijd

    Job description Optimizing the utilization of OR resources is critical for the sustainability of surgical care. The demand for surgical care is increasing and surpasses the supply, which is unable to grow due to budgetary restrictions and a shortage of operating room staff. This PhD position focuses on the implementation, evaluation and scaling up digital...

  • PhD candidate: AI-driven operating room schedule optimization

    2 weken geleden

    Rotterdam, Nederland Erasmus MC Voltijd

    Job description Optimizing the utilization of operating room (OR) resources is critical for the sustainability of surgical care. The demand for surgical care is increasing and currently surpasses the supply, which is unable to grow due to budgetary restrictions, a shortage of personal staff but also limitations in OR availability. Further enhancing the...

  • PhD candidate: AI-driven operating room schedule optimization

    2 weken geleden

    Rotterdam, Nederland Erasmus MC Voltijd

    Job description Optimizing the utilization of operating room (OR) resources is critical for the sustainability of surgical care. The demand for surgical care is increasing and currently surpasses the supply, which is unable to grow due to budgetary restrictions, a shortage of personal staff but also limitations in OR availability. Further enhancing...

  • PhD student in Health Data Science

    7 dagen geleden

    Rotterdam, Nederland Erasmus MC Voltijd

    Job description The department of Medical Informatics is looking for a PhD student to work on cutting-edge health AI and data science topics. This research will be performed in close collaboration with the Observational Health Data Sciences and Informatics (OHDSI) initiative, which is a global, multi-stakeholder, interdisciplinary collaborative to bring out...

  • PhD student in Health Data Science

    7 dagen geleden

    Rotterdam, Zuid-Holland, Nederland Erasmus MC Voltijd

    Job descriptionThe department of Medical Informatics is looking for a PhD student to work on cutting-edge health AI and data science topics. This research will be performed in close collaboration with the Observational Health Data Sciences and Informatics (OHDSI) initiative, which is a global, multi-stakeholder, interdisciplinary collaborative to bring out...

  • PhD candidate on novel antimicrobials for bacterial airway infections

    5 dagen geleden

    Rotterdam, Zuid-Holland, Nederland Erasmus MC Voltijd

    Functie inhoudWe offer a 4-year PhD position to test a new generation of antibiotics as a treatment for respiratory tract infections. This project is funded by ZonMw OPEN and unites the expertise of 4 academic research groups: Pediatric Infectious Diseases, Erasmus MC, Pharmacology University Utrecht; Microbiology University Utrecht and Chemical Biology and...

  • PhD candidate: implementation of digital tools and AI-driven scheduling in the OR

    2 weken geleden

    Rotterdam, Nederland Erasmus MC Voltijd

    Job description Optimizing the utilization of OR resources is critical for the sustainability of surgical care. The demand for surgical care is increasing and surpasses the supply, which is unable to grow due to budgetary restrictions and a shortage of operating room staff. This PhD position focuses on the implementation, evaluation and scaling up...

  • PhD candidate: automation of preoperative planning and intraoperative assistance

    2 weken geleden

    Rotterdam, Nederland Erasmus MC Voltijd

    Job description Optimizing the utilization of OR resources is critical for the sustainability of surgical care. The demand for surgical care is increasing and surpasses the supply, which is unable to grow due to budgetary restrictions and a shortage of operating room staff. As a Phd candidate in automation of preoperative planning and intraoperative...

  • PhD candidate: automation of preoperative planning and intraoperative assistance

    2 weken geleden

    Rotterdam, Nederland Erasmus MC Voltijd

    Job description Optimizing the utilization of OR resources is critical for the sustainability of surgical care. The demand for surgical care is increasing and surpasses the supply, which is unable to grow due to budgetary restrictions and a shortage of operating room staff. As a Phd candidate in automation of preoperative planning and intraoperative...

  • Postdoc Scientist Cardiovascular Epidemiology Group

    2 weken geleden

    Rotterdam, Nederland Erasmus MC Voltijd

    Job description Atrial fibrillation (AF) is progressive cardiac arrhythmia with a highly variable clinical picture. AF episodes last for few minutes in one patient and for hours to days in another patient. It is currently unknown which factors determine the AF severity. This project focuses on unraveling these factors in 2 different populations. The...

  • Postdoctoral Fellow to Study The Hematopoietic Stem

    5 dagen geleden

    Rotterdam, Nederland Erasmus MC Voltijd

    **Postdoctoral fellow to study the hematopoietic stem cell niche in leukemia**: - Closing date 27-05-2024 - 18.03.24.TDdH - 36 hours - Research university - Research & Education Apply- Closing date 27-05-2024 - 18.03.24.TDdH - Job description**Job description**: The Department of Hematology at the Erasmus Medical Center Cancer Institute runs an ambitious...

  • Phd Student Caring in The Liminal Space(S) of a

    4 weken geleden

    Rotterdam, Nederland Erasmus School of Health Policy & Management (ESHPM) Voltijd

    Plaatsingsdatum donderdag 18 apr 2024 Sluitingsdatum maandag 10 jun 2024 Functietype PhD Organisatieonderdeel Erasmus School of Health Policy & Management (ESHPM) Salaris € 2.770 - € 3.539 Omvang 0,8 fte - 1 fte Introductie Heb jij (bijna) een master in de sociale wetenschappen afgerond? En zou je graag willen promoveren op een plek waar actuele...

  • Postdoc Scientist Cardiovascular Epidemiology Group

    2 weken geleden

    Rotterdam, Nederland Erasmus MC Voltijd

    Job description Atrial fibrillation (AF) is progressive cardiac arrhythmia with a highly variable clinical picture. AF episodes last for few minutes in one patient and for hours to days in another patient. It is currently unknown which factors determine the AF severity. This project focuses on unraveling these factors in 2 different populations. The first...

  • Postdoc Scientist Cardiovascular Epidemiology Group

    2 weken geleden

    Rotterdam, Zuid-Holland, Nederland Erasmus MC Voltijd

    Job descriptionAtrial fibrillation (AF) is progressive cardiac arrhythmia with a highly variable clinical picture. AF episodes last for few minutes in one patient and for hours to days in another patient. It is currently unknown which factors determine the AF severity. This project focuses on unraveling these factors in 2 different populations. The first...

  • Assistant Professor in Biostatistics

    2 weken geleden

    Rotterdam, Nederland Erasmus MC Voltijd

    Job description The Department of Biostatistics and Epidemiology of Erasmus MC seeks a motivated assistant professor to establish a new research line in the intersection of statistics, causal inference, and machine learning. The scope of the new research line is broad and should complement the existing research lines within the department. This...

  • it specialist

    3 weken geleden

    Rotterdam, Zuid-Holland, Nederland Department Of The Army Voltijd

    Summary This is a Direct Hire Authority (DHA) solicitation utilizing the DHA for DHA for certain DOD Personnel to recruit and appoint qualified candidates to positions in the competitive service.About the Position: RECRUITMENT/RELOCATION/RETENTION INCENTIVE may be requested through management. DutiesServe as an Information Technology Specialist...

  • Trial Management Director

    5 dagen geleden

    Rotterdam, Zuid-Holland, Nederland J&J Family of Companies Voltijd

    Trial Management Director (MA WDescriptionDirector, Trial ManagementJohnson & Johnson Innovative Medicine is recruiting for a Director, Trial Management ( Medical Affairs Delivery Unit ) to be located in the US (Horsham, PA; La Jolla, CA; Raritan, NJ; Spring House, PA; Titusville, NJ), Europe (Basel, CH; Beerse BE; High Wycombe, UK; Cork, IE; Leiden, NL), or...