Postdoctoral Researcher: Microbial Metabolite Biomarkers for Immunotherapy Outcome
1 maand geleden
Immunotherapy has become the treatment of choice for many cancers but the treatment is expensive and the outcome variable. Biomarkers that predict treatment outcome are thus highly desired.
Several studies have shown that our gut microbiome affects the response to and toxicity of cancer immunotherapy. The mechanism underlying this correlation can be mediated by direct or indirect interactions between gut microbes and the immune system, but microbial metabolites are thought to be key mediators.
Among the microbial metabolites found in humans, small chain fatty acids (SCFAs) such as butyrate have emerged as potential mediators affecting response, but validation studies in large cohorts are lacking. In this project, you will validate the predictive value of plasma SCFAs for cancer immunotherapy response in a large cohort of non-small cell lung cancer patients and provide a solid basis for clinical implementation of these promising biomarkers.
Even though SCFAs have consistently emerged as predictive metabolites, the spectrum of microbiome-derived metabolites in humans is much wider and remains largely unexplored. In this project, you will use untargeted metabolomics to discover other microbial metabolites that could serve as predictive biomarkers and entry point into new immunomodulatory mechanisms.
In this project, you will develop and validate quantitative LC-MS methods for microbial metabolites with suspected immunomodulatory activity (eg. SCFAs). You will apply these methods to plasma samples collected in the ongoing multicentre DEDICATION (NVALT 30) study coordinated by the Radboud university medical center. You will also analyse these samples using untargeted metabolomics to search for new predictive microbial metabolites.
You will communicate your results at interdisciplinary DEDICATION meetings and at international meetings and in scientific journals. To help our postdoctoral researchers receive training, develop their personal and professional skills and prepare for the future, they are organised through an institutional Postdoc Platform.
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Nijmegen, Nederland Radboud University VoltijdPharmaceuticals are essential for human well-being. However, the production and use of pharmaceuticals can harm the environment, for example through the use of solvents and the emission of greenhouse gases in the production phase and the emission of pharmaceutical residues in the use phase. As a postdoctoral researcher, you will focus your research on the...
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Postdoctoral Researcher: Environmental Risk Assessment
3 weken geleden
Nijmegen, Nederland Radboud University VoltijdThe Human and Ecological Risk Assessment (HERA) group of the Department of Environmental Science is actively involved in the development of new methodologies to assess the environmental risks of chemicals. We have a strong focus on computer models that simulate the emission, fate and effects of chemicals in the environment. We aim to develop models that are...
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Nijmegen, Nederland Radboud University VoltijdWe are looking for a postdoctoral researcher to join the BabyBRAIN lab. In this position, you will conduct research on learning and curiosity in early development, using behavioural, neuroscientific and modelling approaches. You will work closely with Prof. Sabine Hunnius and Dr Marlene Meyer and will be involved in the supervision of ongoing PhD...
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Postdoctoral Researcher: Systems Biology of Malaria Gametocytes
2 weken geleden
Nijmegen, Gelderland, Nederland Radboud Universiteit VoltijdAre you interested in studying sexual stages of malaria parasites and provide knowledge for malaria transmission blocking strategies? And do you cherish the power of omics technologies in dissecting complex cellular differentiation processes? Then join the Department of Molecular Biology as a postdoctoral researcher.We are looking for an ambitious...
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Postdoctoral researcher in sociogenomics
2 dagen geleden
Nijmegen, Nederland Max Planck Institute for Psycholinguistics VoltijdJob description The successful candidate will co-lead a project on sociogenomics (behavioral genetics) and language development. Among other things, the project seeks to understand the causes and consequences of individual differences in language learning in early childhood. This is done by applying concepts derived from the Familial Control Method...
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Nijmegen, Nederland Radboud University VoltijdThe DIALOG project and this associated postdoctoral position are funded under the Single European Sky Air Traffic Management Research Joint Undertaking (SESAR JU). In the DIALOG project we work on an AI-based digital assistant that uses information from the air traffic controllers’ estimated state, traffic situation and general context to anticipate air...
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Nijmegen, Nederland Radboud University VoltijdIn this PhD position you will develop and analyse a new class of Markov chain Monte Carlo algorithms (such as Gibbs Sampling and Metropolis-Hastings) that make use of a novel technology that is currently only available in specialist labs. Using dedicated photonic manipulation, researchers can build covarying bits out of magnetic fields at the nanoscale that...
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Nijmegen, Nederland Radboud University VoltijdAs a coordinator at the Radboud Centre for Sustainability Challenges (RCSC), you will be responsible for further developing the centre into a hub where researchers and lecturers from different faculties work together on sustainability issues. Your duties will be both substantive and organisational in nature. As a discussion partner of researchers and...
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PhD Candidate: Visual Perception and Decision-Making
2 weken geleden
Nijmegen, Gelderland, Nederland Radboud Universiteit VoltijdA PhD position is available in Dr Janneke Jehee's lab at the Donders Institute for Brain, Cognition and Behaviour. You will work on studies of visual decision-making, sensory uncertainty, and decision confidence. Research methods include computational modelling, brain imaging (fMRI, MEG), machine learning, behavioural methods, and other techniques.Virtually...
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Full Professor of Anthropology and Development Studies
1 maand geleden
Nijmegen, Nederland Radboud University VoltijdWe are looking for a full professor who can strengthen our profile in the multidisciplinary and shifting field of anthropology and development studies. You will push the intellectual boundaries in studying societal change as well as contribute to decolonising change by making our department a place to rethink and craft alternative, more inclusive futures in...
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PhD Candidates: History of Philosophy in the Islamic World
1 maand geleden
Nijmegen, Nederland Radboud University VoltijdYou will join the research team of Dr Andreas Lammer and work closely with him, with another PhD Candidate, and with a postdoctoral researcher, contributing to the ERC Starting Grant project “Avicenna Live: The Immediate Context of Avicenna’s Intellectual Formation” (ALIVE). You will produce original research either on the contents of a unique...
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Postdoctoraal Onderzoeker: Project Integrating
1 maand geleden
Nijmegen, Nederland Radboud Universiteit VoltijdDienstverband 0,6 - 0,8 fte Bruto maandsalaris € 4.332 - € 5.929 Werk/denkniveau Gepromoveerd Organisatieonderdeel Faculteit der Letteren Reageer uiterlijk 15 mei 2024 Beleidsmakers hechten waarde aan geschiedenis, maar van een systematische toepassing van historische inzichten en vaardigheden in de beleidspraktijk is echter geen sprake. Als postdoc...
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Nijmegen, Nederland Radboud University VoltijdThis position is part of the NWO project ’Conceptualizing, Measuring, and Predicting Peer Relationships in Emerging Adulthood’. Primary responsibilities involve writing and collaborating with other team members on several high impact journal articles (in English), involving the most recently collected waves of NLS data. Specifically, you will be...
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PhD Candidate: Network Science for Green AI
2 dagen geleden
Nijmegen, Nederland Radboud University VoltijdArtificial Neural Networks (ANNs) are driving new applications in AI, data science and intelligent systems. Yet, their training demands significant computational power, leading to a need for energy-efficient techniques that work well on lightweight devices. Random sparse ANNs have shown promise in addressing this challenge. However, the full understanding...
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Technisch Assistent Neurobiologie
4 weken geleden
Nijmegen, Nederland Radboud University VoltijdAls technisch assistent Neurobiologie maak je deel uit van het onderzoeksteam van de sectie Neurobiologie bij het Donders Centre for Neuroscience (DCN). Je bent betrokken bij het uitvoeren van gedragsexperimenten met knaagdieren, bij het bereiden van media voor fruitvliegkweek, het transfereren van fruitvliegen naar vers medium en bij het wassen en...
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Research analist Neurobiologie
3 weken geleden
Nijmegen, Nederland Radboud University VoltijdAls Research Analist Neurobiologie maak je deel uit van het Storkebaum lab in de neurobiologie sectie van het Donders Center for Neuroscience. Je bent verantwoordelijk voor het uitvoeren van gedragsexperimenten met muizen, elektrofysiologie, weefsel dissectie, histologische en immunohistochemische analyse, en confocale imaging. Je werkt mee aan projecten...
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Nijmegen, Gelderland, Nederland Radboud Universiteit VoltijdDo you have a passion for research and are you interested in audio machine learning for technological and neuroscientific applications? Are you eager to tackle complex problems and to develop creative solutions? Then join the Donders Centre for Cognition as a PhD candidateUniversal audio embedding models capable of performing a humanlike range of hearing...
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Nijmegen, Nederland Radboud University VoltijdThe project is embedded in Dr Inti Brazil’s SAMBA research group, part of the Donders Centre for Cognition, which in turn is part of the Donders Institute. The main focus of the group’s research programme is on combining approaches from experimental psychology, cognitive neuroscience (e.g. neuroimaging), computational modelling and statistical modelling...
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Nijmegen, Nederland Radboud University VoltijdVisual cortical prostheses are devices designed to help restore some level of vision to blind individuals by directly stimulating the visual cortex of the brain. This process often involves using AI to interpret and encode visual data for effective communication to the brain. In the Neural Engineering Lab, we concentrate on this crucial step of interpreting...
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PhD Candidate: Software Security
2 weken geleden
Nijmegen, Gelderland, Nederland Radboud Universiteit VoltijdAre you an aspiring computer science researcher interested in what can be done to make our digital world more secure? Then you have a part to play as a PhD candidate. By investigating techniques to design, analyse and test software, you will help us develop new, innovative methods to improve software security.Cyber security problems have increased...