Associate Director, Pathology
4 maanden geleden
The Role
As a Pathologist at Genmab, you will be part of an international Pathology team embedded within Precision Medicine of our Translational & Quantitative Sciences team based in Princeton, New Jersey. In this role you will work with scientists in a state-of-the-art histology and immunohistochemistry laboratory to support a variety of discovery, pre-clinical and clinical programs.
Responsibilities
The anatomic pathologist in this role will impact Genmab’s pipeline from early research to clinical trial stages, providing expertise in histopathological evaluation, tissue-based assay development (IHC, ISH, IF), biomarker strategy and toxicologic pathology for a variety of antibody therapeutics. Scientific curiosity, strategic thinking, and the capacity to work well in cross-functional teams are important traits of the successful candidate.
You will contribute your pathology expertise by both traditional slide evaluation, and by guiding the development and interpretation of advanced tissue-based assays, such as multiplex immunofluorescence panels, digital image analysis, and machine learning image projects.
Your responsibilities include but are not limited to the following:
Help laboratory personnel in our US and European locations to design and develop immunohistochemistry assays for single-plex chromogenic and fluorescence, in situ hybridization (ISH) assays, multiplex IF and ISH-IF combinations (10% lab work IHC/IF assay development).
Support our digital pathology team and work closely with Data Sciences to develop and verify digital image analysis algorithms and results from image analysis projects.
Evaluate, qualitatively and quantitatively (H-Scores, % staining, etc) a variety of immunohistochemical stains for target screening and biomarker assessment.
Serve as in-house expert representing Genmab in interactions with CROs developing IHC and ISH assays to support our pre-clinical and clinical biomarker programs.
Perform, as needed, primary reads and/or peer review of pre-clinical toxicology studies, including tissue cross reactivity studies, investigative and GLP studies.
Provide internal expertise to understand the mechanisms of toxicity observed non-clinically or clinically in order to help design mitigation strategies and minimize risk to patients.
Contribute with evaluation, and implementation of new technologies and techniques for tissue-based assays and digital image analysis applications.
Requirements
Doctor in Veterinary Medicine or equivalent degree, with a minimum of 2-5 years of relevant experience supporting discovery and development organizations.
Diplomate, American College of Veterinary Pathologists (or equivalent) in anatomic pathology.
Graduate degree (Master’s or PhD) desired.
Solid experience with design and interpretation of immunohistochemistry assays and digital pathology applications.
Strategic thinking, innovative and collaborative mindset and a willingness to work in multidisciplinary teams.
Basic knowledge of statistics and data visualization software (SAS, GraphPad, Spotfire).
Experience managing pathology laboratories desired, but not required.
Background in immunology and immuno-oncology, knowledge of biomarker development and companion diagnostic development is desired but not required.
For US based candidates, the proposed salary band for this position is as follows:
$,.00---$,.00The actual salary offer will carefully consider a wide range of factors, including your skills, qualifications, experience, and location. Also, certain positions are eligible for additional forms of compensation, such as bonuses.
About You
- You are passionate about our purpose and genuinely care about our mission to transform the lives of patients through innovative cancer treatment
- You bring rigor and excellence to all that you do. You are a fierce believer in our rooted-in-science approach to problem-solving
- You are a generous collaborator who can work in teams with diverse backgrounds
- You are determined to do and be your best and take pride in enabling the best work of others on the team
- You are not afraid to grapple with the unknown and be innovative
- You have experience working in a fast-growing, dynamic company (or a strong desire to)
- You work hard and are not afraid to have a little fun while you do so
Locations
Genmab leverages the effectiveness of an agile working environment, when possible, for the betterment of employee work-life balance. Our offices are designed as open, community-based spaces that work to connect employees while being immersed in our state-of-the-art laboratories. Whether you’re in one of our collaboratively designed office spaces or working remotely, we thrive on connecting with each other to innovate.
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