Associate Director, Pathology

3 weken geleden

Utrecht, Nederland Genmab Voltijd

The Role


As a Pathologist at Genmab, you will be part of an international Pathology team embedded within Precision Medicine of our Translational & Quantitative Sciences team based in Princeton, New Jersey. In this role you will work with scientists in a state-of-the-art histology and immunohistochemistry laboratory to support a variety of discovery, pre-clinical and clinical programs.

Responsibilities

The anatomic pathologist in this role will impact Genmab’s pipeline from early research to clinical trial stages, providing expertise in histopathological evaluation, tissue-based assay development (IHC, ISH, IF), biomarker strategy and toxicologic pathology for a variety of antibody therapeutics.  Scientific curiosity, strategic thinking, and the capacity to work well in cross-functional teams are important traits of the successful candidate.

You will contribute your pathology expertise by both traditional slide evaluation, and by guiding the development and interpretation of advanced tissue-based assays, such as multiplex immunofluorescence panels, digital image analysis, and machine learning image projects.

Your responsibilities include but are not limited to the following:

  • Help laboratory personnel in our US and European locations to design and develop immunohistochemistry assays for single-plex chromogenic and fluorescence, in situ hybridization (ISH) assays, multiplex IF and ISH-IF combinations (10% lab work IHC/IF assay development).

  • Support our digital pathology team and work closely with Data Sciences to develop and verify digital image analysis algorithms and results from image analysis projects.

  • Evaluate, qualitatively and quantitatively (H-Scores, % staining, etc) a variety of immunohistochemical stains for target screening and biomarker assessment.

  • Serve as in-house expert representing Genmab in interactions with CROs developing IHC and ISH assays to support our pre-clinical and clinical biomarker programs.

  • Perform, as needed, primary reads and/or peer review of pre-clinical toxicology studies, including tissue cross reactivity studies, investigative and GLP studies.

  • Provide internal expertise to understand the mechanisms of toxicity observed non-clinically or clinically in order to help design mitigation strategies and minimize risk to patients.

  • Contribute with evaluation, and implementation of new technologies and techniques for tissue-based assays and digital image analysis applications.

Requirements

  • Doctor in Veterinary Medicine or equivalent degree, with a minimum of 2-5 years of relevant experience supporting discovery and development organizations.

  • Diplomate, American College of Veterinary Pathologists (or equivalent) in anatomic pathology.

  • Graduate degree (Master’s or PhD) desired.

  • Solid experience with design and interpretation of immunohistochemistry assays and digital pathology applications.

  • Strategic thinking, innovative and collaborative mindset and a willingness to work in multidisciplinary teams.

  • Basic knowledge of statistics and data visualization software (SAS, GraphPad, Spotfire).

  • Experience managing pathology laboratories desired, but not required.

  • Background in immunology and immuno-oncology, knowledge of biomarker development and companion diagnostic development is desired but not required.

For US based candidates, the proposed salary band for this position is as follows:

$,.00---$,.00

The actual salary offer will carefully consider a wide range of factors, including your skills, qualifications, experience, and location. Also, certain positions are eligible for additional forms of compensation, such as bonuses.

About You

  • You are passionate about our purpose and genuinely care about our mission to transform the lives of patients through innovative cancer treatment
  • You bring rigor and excellence to all that you do. You are a fierce believer in our rooted-in-science approach to problem-solving
  • You are a generous collaborator who can work in teams with diverse backgrounds
  • You are determined to do and be your best and take pride in enabling the best work of others on the team
  • You are not afraid to grapple with the unknown and be innovative
  • You have experience working in a fast-growing, dynamic company (or a strong desire to)
  • You work hard and are not afraid to have a little fun while you do so

Locations

Genmab leverages the effectiveness of an agile working environment, when possible, for the betterment of employee work-life balance. Our offices are designed as open, community-based spaces that work to connect employees while being immersed in our state-of-the-art laboratories. Whether you’re in one of our collaboratively designed office spaces or working remotely, we thrive on connecting with each other to innovate.

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