PhD Position Modeling Cellular Deformation
2 maanden geleden
Do you want to understand how life works at the molecular scale by helping us study and design methods for deforming and dividing synthetic cells? Job description
Living cells are highly complex systems made of countless lifeless molecular components. We do not understand how these interact to form a living cell that sustains itself, grows and divides. The BaSyC (‘Building a Synthetic Cell’) initiative is a collaborative 10-year research program that aims to understand ‘how life works’ by building an autonomous self-reproducing synthetic cell from the bottom up.
A key aspect of life is that it can reproduce. In order to duplicate itself, a cell needs to go through at least three steps: (1) replicate all its material, (2) deform its container and (3) split. To achieve these three steps, cells contain dedicated machinery. For the deformation and division steps, cells across kingdoms build self-assembling ring structures from protein filaments, such as the actin/septin ring in eukaryotic cells and the FtsZ ring in bacteria. Active contraction of these rings is key to both deformation and splitting. These processes will need to be reproduced in any artificial cell.
In this project, we’ll focus on step 2, investigating how the deformation can be achieved using materials that are either encapsulated or expressed inside the artificial cell. In particular, we want to find the conditions under which a membrane-deforming structure can autonomously first self-assemble on the inside of the vesicle and then actively deform it to a shape that can be split. We aim for a symmetric final shape that has higher total bending energy than two spherical daughter vesicles, even though there may still be an energy barrier involved in the actual splitting process. To achieve this goal, we will use a combination of analytical and numerical tools, and work in close collaboration with experimental groups, in particular the Koenderink and Dekker labs in the same department.
The position is in the theoretical biophysics group of Dr. Timon Idema in the Department of Bionanoscience. Requirements
We seek an outstanding theoretical (bio)physicist with a strong affinity for research at the interface of physics and biology and with relevant research experience in fields such as membrane, molecular, or cell biophysics or soft matter physics. We are looking for a candidate with a high level of intellectual creativity, genuine interest in fundamental research, who enjoys collaborations and easily communicates with scientists from different disciplines.
Applicants must
Hold a Master’s degree, or approach its completion, in physics, mathematics, nanobiology, chemistry, or a closely related discipline. Have excellent written and spoken English skills (see below). Thrive in an international, ambitious, multidisciplinary, and highly collaborative environment.Doing a PhD at TU Delft requires English proficiency at a certain level to ensure that the candidate is able to communicate and interact well, participate in English-taught Doctoral Education courses, and write scientific articles and a final thesis. Conditions of employment
Doctoral candidates will be offered a 4-year period of employment in principle, but in the form of 2 employment contracts. An initial 1,5 year contract with an official go/no go progress assessment within 15 months. Followed by an additional contract for the remaining 2,5 years assuming everything goes well and performance requirements are met.
Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities, increasing from € 2770 per month in the first year to € 3539 in the fourth year. As a PhD candidate you will be enrolled in the TU Delft Graduate School. The TU Delft Graduate School provides an inspiring research environment with an excellent team of supervisors, academic staff and a mentor. The Doctoral Education Programme is aimed at developing your transferable, discipline-related and research skills.
The TU Delft offers a customisable compensation package, discounts on health insurance, and a monthly work costs contribution. Flexible work schedules can be arranged.
For international applicants, TU Delft has the Coming to Delft Service. This service provides information for new international employees to help you prepare the relocation and to settle in the Netherlands. The Coming to Delft Service offers a Dual Career Programme for partners and they organise events to expand your (social) network. TU Delft (Delft University of Technology)
Delft University of Technology is built on strong foundations. As creators of the world-famous Dutch waterworks and pioneers in biotech, TU Delft is a top international university combining science, engineering and design. It delivers world class results in education, research and innovation to address challenges in the areas of energy, climate, mobility, health and digital society. For generations, our engineers have proven to be entrepreneurial problem-solvers, both in business and in a social context.
At TU Delft we embrace diversity as one of our core values and we actively engage to be a university where you feel at home and can flourish. We value different perspectives and qualities. We believe this makes our work more innovative, the TU Delft community more vibrant and the world more just. Together, we imagine, invent and create solutions using technology to have a positive impact on a global scale. That is why we invite you to apply. Your application will receive fair consideration.
Challenge. Change. Impact Faculty Applied Sciences
With more than 1,100 employees, including 150 pioneering principal investigators, as well as a population of about 3,600 passionate students, the Faculty of Applied Sciences is an inspiring scientific ecosystem. Focusing on key enabling technologies, such as quantum- and nanotechnology, photonics, biotechnology, synthetic biology and materials for energy storage and conversion, our faculty aims to provide solutions to important problems of the 21st century. To that end, we educate innovative students in broad Bachelor's and specialist Master's programmes with a strong research component. Our scientists conduct ground-breaking fundamental and applied research in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Engineering Physics. We are also training the next generation of high school teachers.
We hebben andere actuele vacatures op dit gebied die je hieronder kunt vinden
-
PhD Position Modeling Cellular Deformation
3 weken geleden
Delft, Zuid-Holland, Nederland Delft University of Technology VoltijdDo you want to understand how life works at the molecular scale by helping us study and design methods for deforming and dividing synthetic cells?Job descriptionLiving cells are highly complex systems made of countless lifeless molecular components. We do not understand how these interact to form a living cell that sustains itself, grows and divides. The...
-
PhD Position Modeling Cellular Deformation
2 maanden geleden
Delft, Zuid-Holland, Nederland Delft University of Technology VoltijdDo you want to understand how life works at the molecular scale by helping us study and design methods for deforming and dividing synthetic cells?Job descriptionLiving cells are highly complex systems made of countless lifeless molecular components. We do not understand how these interact to form a living cell that sustains itself, grows and divides. The...
-
PhD position
4 weken geleden
Delft, Zuid-Holland, Nederland Delft University of Technology VoltijdBackgroundCellular Agriculture (CA) is a new concept in biotechnology that aims to produce animal protein through bioprocessing. This includes the production of muscle cells and tissue from animal stem cells (rather than from whole animals), as well as the use of precision fermentation for microbial production of animal protein, such as dairy alternatives....
-
PhD position
6 dagen geleden
Delft, Zuid-Holland, Nederland Delft University of Technology VoltijdBackgroundCellular Agriculture (CA) is a new concept in biotechnology that aims to produce animal protein through bioprocessing. This includes the production of muscle cells and tissue from animal stem cells (rather than from whole animals), as well as the use of precision fermentation for microbial production of animal protein, such as dairy alternatives....
-
PhD position
3 weken geleden
Delft, Zuid-Holland, Nederland Delft University of Technology VoltijdBackgroundCellular Agriculture (CA) is a new concept in biotechnology that aims to produce animal protein through bioprocessing. This includes the production of muscle cells and tissue from animal stem cells (rather than from whole animals), as well as the use of precision fermentation for microbial production of animal protein, such as dairy alternatives....
-
PhD position
3 weken geleden
Delft, Nederland Delft University of Technology VoltijdBackground Cellular Agriculture (CA) is a new concept in biotechnology that aims to produce animal protein through bioprocessing. This includes the production of muscle cells and tissue from animal stem cells (rather than from whole animals), as well as the use of precision fermentation for microbial production of animal protein, such as dairy alternatives....
-
PhD position
3 weken geleden
Delft, Nederland Delft University of Technology VoltijdBackground Cellular Agriculture (CA) is a new concept in biotechnology that aims to produce animal protein through bioprocessing. This includes the production of muscle cells and tissue from animal stem cells (rather than from whole animals), as well as the use of precision fermentation for microbial production of animal protein, such as dairy alternatives....
-
Phd Position Modeling and Monitoring of
2 weken geleden
Delft, Nederland TU Delft VoltijdPhD Position Modeling and Monitoring of Fiber-reinforced Composite Ships Under Extreme Loads- **_This PhD position deals with development of innovative modeling and monitoring methods for ship structures made of fiber-reinforced composites under extreme loads._** Job description Fiber-reinforced composite (FRC) structural members offer significant...
-
PhD position
1 maand geleden
Delft, Nederland TU Delft VoltijdJob description PhD Research project As part of this new and exciting research program at TU Delft, we are seeking to hire a PhD student to contribute to the development of CA, focusing on the engineering of mammalian cell lines with desirable properties for upscaled cultivated meat production. Such properties include immortalisation,...
-
PhD position
3 weken geleden
Delft, Nederland TU Delft VoltijdJob description PhD Research project As part of this new and exciting research program at TU Delft, we are seeking to hire a PhD student to contribute to the development of CA, focusing on the engineering of mammalian cell lines with desirable properties for upscaled cultivated meat production. Such properties include immortalisation,...
-
PhD Position Modeling and Simulation of Local Energy Communities
2 maanden geleden
Delft, Zuid-Holland, Nederland Delft University of Technology VoltijdJoin us and start your carrier as a researcher and scientist in the field of power and energy systems. Develop models for local energy communities and speed up energy transition at local scale.Job descriptionDelft University of Technology is hiring a doctoral candidate on the subject of "Modeling and Simulation of Local Energy Communities". In order to...
-
Phd Position Enhancing Plant Resilience Through
2 weken geleden
Delft, Nederland TU Delft VoltijdPhD Position Enhancing Plant Resilience through Biologically-Inspired Machine Learning- Join us in advancing the frontier of plant sciences and making a tangible impact on agricultural resilience through the power of machine learning! Job description The project is part of the Crop-XR program, a highly collaborative 10-year national initiative of...
-
PhD Position Spread in Networks
3 weken geleden
Delft, Nederland TU Delft VoltijdJob description Epidemic processes widely apply to biological and computer network viruses, to cascading failures in power grids, to the spread of news, rumour or emotions in a social network, to transactions in banking networks and to the processing of functions and movements in the human brain. An epidemic process spreads over an underlying...
-
PhD Position Spread in Networks
3 weken geleden
Delft, Nederland TU Delft VoltijdJob description Epidemic processes widely apply to biological and computer network viruses, to cascading failures in power grids, to the spread of news, rumour or emotions in a social network, to transactions in banking networks and to the processing of functions and movements in the human brain. An epidemic process spreads over an underlying...
-
Phd Position Validating Automatically Generated Code
5 dagen geleden
Delft, Nederland TU Delft VoltijdPhD Position Validating Automatically Generated Code- - Make the code generated by AI more robust: Exploring the techniques for validating the automatically generated code._ Job description AI-powered coding tools are set to revolutionize how we develop software. These AI tools are based on machine learning (ML) models trained on massive collections of...
-
PhD Position Distributed
3 weken geleden
Delft, Zuid-Holland, Nederland Delft University of Technology VoltijdJob descriptionWe seek a motivated PhD student to work on a 4-year NWO funded project called DARE (Distributed and Adaptive Radar for Enhanced Sensing and Classification).The goal of this project is to work towards transitioning radar from a conventional stand-alone sensor to an intelligent and spatially distributed network of cooperative nodes. The...
-
PhD Position Distributed
2 maanden geleden
Delft, Zuid-Holland, Nederland Delft University of Technology VoltijdJob descriptionWe seek a motivated PhD student to work on a 4-year NWO funded project called DARE (Distributed and Adaptive Radar for Enhanced Sensing and Classification).The goal of this project is to work towards transitioning radar from a conventional stand-alone sensor to an intelligent and spatially distributed network of cooperative nodes. The...
-
PhD Position Distributed
2 maanden geleden
Delft, Zuid-Holland, Nederland Delft University of Technology VoltijdJob descriptionWe seek a motivated PhD student to work on a 4-year NWO funded project called DARE (Distributed and Adaptive Radar for Enhanced Sensing and Classification).The goal of this project is to work towards transitioning radar from a conventional stand-alone sensor to an intelligent and spatially distributed network of cooperative nodes. The...
-
PhD Position Distributed
6 dagen geleden
Delft, Zuid-Holland, Nederland Delft University of Technology VoltijdJob descriptionWe seek a motivated PhD student to work on a 4-year NWO funded project called DARE (Distributed and Adaptive Radar for Enhanced Sensing and Classification).The goal of this project is to work towards transitioning radar from a conventional stand-alone sensor to an intelligent and spatially distributed network of cooperative nodes. The...
-
PhD Position Distributed
3 weken geleden
Delft, Zuid-Holland, Nederland Delft University of Technology VoltijdJob descriptionWe seek a motivated PhD student to work on a 4-year NWO funded project called DARE (Distributed and Adaptive Radar for Enhanced Sensing and Classification).The goal of this project is to work towards transitioning radar from a conventional stand-alone sensor to an intelligent and spatially distributed network of cooperative nodes. The...
