Huidige banen gerelateerd aan Two PhD positions in Cellular imaging and Neuroscience - Amsterdam, Noord-Holland - University of Amsterdam
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PhD Student in Cellular Neuroscience
4 weken geleden
Amsterdam, Noord-Holland, Nederland Vrije Universiteit Amsterdam VoltijdJob Title: PhD Student in Cellular NeuroscienceWe are seeking a highly motivated PhD student to join our research group at the Vrije Universiteit Amsterdam. The successful candidate will work on a project focused on deciphering how mRNAs are captured at specific subcellular locations to support local translation in neurons.Job Description:The project...
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PhD Student in Cellular Neuroscience
4 weken geleden
Amsterdam, Noord-Holland, Nederland Vrije Universiteit Amsterdam VoltijdJob Title: PhD Student in Cellular NeuroscienceWe are seeking a highly motivated PhD student to join our research group at the Vrije Universiteit Amsterdam. The successful candidate will work on a project focused on deciphering how mRNAs are captured at specific subcellular locations to support local translation in neurons.About the ProjectThe project aims...
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PhD Researcher in Cellular Neuroscience
4 weken geleden
Amsterdam, Noord-Holland, Nederland VU Amsterdam VoltijdJob DescriptionProject OverviewWe are seeking a highly motivated PhD researcher to investigate the dynamics of organelles and mRNAs in neurons. The successful candidate will use novel genetic and imaging tools to study the mechanisms of mRNA localization and translation in neurons.Key ResponsibilitiesInvestigate the dynamics of organelles and mRNAs using...
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PhD Researcher in Cellular Neuroscience
1 maand geleden
Amsterdam, Noord-Holland, Nederland VU Amsterdam VoltijdProject OverviewWe are seeking a highly motivated PhD candidate to investigate the dynamics of organelles and mRNAs in neurons. The project aims to decipher how mRNAs are captured at specific subcellular locations to support local translation in neurons.The successful candidate will use genetic and imaging tools to investigate how different organelles and...
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PhD Researcher in Cellular Neuroscience
4 weken geleden
Amsterdam, Noord-Holland, Nederland VU Amsterdam VoltijdProject OverviewWe are seeking a highly motivated PhD candidate to investigate the dynamics of organelles and mRNAs in neurons using novel genetic and imaging tools. The project aims to decipher how mRNAs are captured at specific subcellular locations to support local translation in neurons.Key ResponsibilitiesInvestigate and control the dynamics of...
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PhD Student in Cellular Neuroscience
4 weken geleden
Amsterdam, Noord-Holland, Nederland Vrije Universiteit Amsterdam VoltijdJob Title: PhD Student in Cellular NeuroscienceWe are seeking a highly motivated PhD student to join our research group at the Vrije Universiteit Amsterdam. The successful candidate will work on a project focused on deciphering how mRNAs are captured at specific subcellular locations to support local translation in neurons.About the ProjectThe project aims...
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PhD Student in Cellular Neuroscience
4 weken geleden
Amsterdam, Noord-Holland, Nederland Vrije Universiteit Amsterdam VoltijdJob DescriptionWe are seeking a highly motivated PhD student to join our research group at the Vrije Universiteit Amsterdam. The successful candidate will work on a project focused on deciphering how mRNAs are captured at specific subcellular locations to support local translation in neurons.Project OverviewThe project aims to investigate the mechanisms that...
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PhD Researcher in Molecular Neuroscience
2 weken geleden
Amsterdam, Noord-Holland, Nederland Vrije Universiteit Amsterdam VoltijdJob DescriptionWe are seeking a highly motivated PhD researcher to join our team at the Vrije Universiteit Amsterdam. The successful candidate will be part of the Department of Molecular and Cellular Neuroscience and will work on a project investigating the molecular processes that control synapse nanostructure and function.The project involves the use of...
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PhD Student in Molecular Neuroscience
3 weken geleden
Amsterdam, Noord-Holland, Nederland Vrije Universiteit Amsterdam VoltijdJob Title: PhD Student in Molecular NeuroscienceWe are seeking a highly motivated PhD student to join our research group in molecular neuroscience. The successful candidate will have the opportunity to work on a project investigating the molecular processes that control synapse nanostructure and function.Project Description:The project aims to understand the...
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PhD Student in Molecular Neuroscience
4 weken geleden
Amsterdam, Noord-Holland, Nederland Vrije Universiteit Amsterdam VoltijdAbout the PositionWe are seeking a highly motivated PhD student to join our research team at the Vrije Universiteit Amsterdam. The successful candidate will be working on a project investigating the molecular processes that control synapse nanostructure and function.The project involves using CRISPR/Cas9-based tools, super-resolution microscopy,...
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PhD Candidate in Molecular Neuroscience
3 weken geleden
Amsterdam, Noord-Holland, Nederland VU Amsterdam VoltijdResearch OpportunityProject OverviewWe are seeking a highly motivated PhD candidate to investigate the molecular processes that control synapse nanostructure and function. This project aims to understand how nanoscale molecular processes at synapses control memory formation.Key ResponsibilitiesInvestigate the molecular mechanisms that regulate synapse...
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PhD Researcher in Molecular Neuroscience
2 weken geleden
Amsterdam, Noord-Holland, Nederland Vrije Universiteit Amsterdam VoltijdProject OverviewThe Vrije Universiteit Amsterdam is seeking a highly motivated PhD researcher to investigate the molecular processes that control synapse nanostructure and function. This project is part of the Graduate School ONWAR and is located in the Department of Molecular and Cellular Neuroscience.As a PhD researcher, you will use CRISPR/Cas9-based...
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PhD Student in Molecular Neuroscience
4 weken geleden
Amsterdam, Noord-Holland, Nederland Vrije Universiteit Amsterdam VoltijdJob Title: PhD Student in Molecular NeuroscienceWe are seeking a highly motivated PhD student to join our research team in molecular neuroscience. The successful candidate will have a strong background in life sciences, biomedical sciences, or biophysics with a specialization in neuroscience.Job Description:The PhD student will investigate the molecular...
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PhD Researcher in Molecular Neuroscience
1 maand geleden
Amsterdam, Noord-Holland, Nederland VU Amsterdam VoltijdJob DescriptionProject OverviewWe are seeking a highly motivated PhD candidate to investigate the molecular processes that control synapse nanostructure and function in the context of memory formation. The successful candidate will work in a dynamic and international research environment, utilizing cutting-edge techniques such as CRISPR/Cas9-based tools,...
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PhD Researcher in Molecular Neuroscience
4 weken geleden
Amsterdam, Noord-Holland, Nederland VU Amsterdam VoltijdJob DescriptionProject OverviewWe are seeking a highly motivated PhD candidate to investigate the molecular processes that control synapse nanostructure and function in the context of memory formation. The successful candidate will work in a dynamic and international research environment, utilizing cutting-edge techniques such as CRISPR/Cas9-based tools,...
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PhD Researcher in Molecular Neuroscience
4 weken geleden
Amsterdam, Noord-Holland, Nederland VU Amsterdam VoltijdJob DescriptionProject OverviewWe are seeking a highly motivated PhD candidate to investigate the molecular processes that control synapse nanostructure and function in the context of memory formation. The successful candidate will work in a dynamic and international research environment, utilizing cutting-edge techniques such as CRISPR/Cas9-based tools,...
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PhD Researcher in Molecular Neuroscience
2 weken geleden
Amsterdam, Noord-Holland, Nederland VU Amsterdam VoltijdProject OverviewProject Description:The project aims to investigate the molecular processes that control synapse nanostructure and function. You will use CRISPR/Cas9-based tools, super-resolution microscopy, optogenetics, and electrophysiology to study synapse nanostructure and function in different model systems. The goal is to understand how nanoscale...
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PhD Researcher in Molecular Neuroscience
2 weken geleden
Amsterdam, Noord-Holland, Nederland Vrije Universiteit Amsterdam VoltijdJob DescriptionWe are seeking a highly motivated PhD researcher to join our team at Vrije Universiteit Amsterdam. The successful candidate will be part of the Department of Molecular and Cellular Neuroscience and will work on a project investigating the molecular processes that control synapse nanostructure and function.Key Responsibilities:Investigate the...
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PhD Candidate in Molecular Neuroscience
1 week geleden
Amsterdam, Noord-Holland, Nederland VU Amsterdam VoltijdProject OverviewProject Description:Synaptic plasticity, the ability to modify synaptic strength in response to neuronal activity, plays a crucial role in the brain's capacity to encode memories. Our research aims to understand the molecular events that induce long-term alterations in synaptic structure and function. Recent studies have revealed an exciting...
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PhD Position in Cognitive Neuroscience
3 weken geleden
Amsterdam, Noord-Holland, Nederland Vrije Universiteit Amsterdam VoltijdPhD Position in Cognitive NeuroscienceWe are seeking a highly motivated and talented researcher to join our team at the Vrije Universiteit Amsterdam. As a PhD candidate, you will contribute to our understanding of the reading brain and develop new theories of language processing.Key ResponsibilitiesConduct literature research and participate in internal...
Two PhD positions in Cellular imaging and Neuroscience
4 maanden geleden
We have two positions available for a PhD Student in Cellular imaging and in Neuroscience. The two positions are funded by a grant from NWO "Visualizing and manipulating synaptic AMPA-receptor plasticity with a new molecular toolkit". The two PhD students are expected to closely collaborate within this project.
The two positions are embedded respectively in the following two UvA/SILS research groups:
Molecular Cytology studies the dynamic architecture of living cells. By employing genetic encoded fluorescent biosensors we analyze the molecular interactions between signaling molecules and flow of information across and in the plane of the membrane of living mammalian cells. We aim to understand how cells respond to internal and external cues using advanced microscopy tools.
Project 1: Engineering of novel tools for visualization and manipulation of signaling molecules that drive synaptic plasticity.
This project builds on our efforts to engineer biosensors ad optogenetic tools that can be used in relevant complex biological systems to interrogate signaling networks. In this project protein engineering and microscopy-based screening will be applied to generate new biosensors that have lifetime contrast, as these have advantageous properties for quantitative imaging in complex systems. In addition, we aim to generate genetically encoded components that can manipulate cAMP levels or other signaling components that potentially control synaptic AMPA-receptor plasticity.
Cellular and Computational Neuroscience is part of the SILS Neuroscience theme and investigates the regulation of neuronal excitability and synaptic plasticity mechanism that underlie learning and memory, at the level of cellular and network neuroscience using electrophysiological, live-imaging, pharmacological and molecular techniques.
Project 2: Understanding the synaptic plasticity mechanisms that underlie memory retrieval
In this project the synaptic plasticity processes will be examined that underlie memory retrieval in the hippocampus. We hypothesize that noradrenaline signalling selectively increases the intracellular levels of cyclic AMP at actively communicating synapses, thereby increasing conductance of AMPA-receptors at these synapses. To study these molecular processes, whole-cell electrophysiology will be combined with live-imaging and optogenetics. This project is directly relevant to increase our understanding of how memories can be reactivated and why memory retrieval is impaired in early Alzheimer's disease.
What are you going to do?
As a PhD student, you are expected to:
- complete a PhD thesis within the official appointment duration of four years;
- gain knowledge of the field through literature survey, discussion with team members and internal lab meetings;
- contribute to the design of experiments and perform experiments;
- Analyze and interpret results of experiments;
- enroll in the training program for PhD students in the graduate school ONWAR (Graduate School Neurosciences Amsterdam and Rotterdam);
- teach seminars and/or practical for bachelor and master students;
- supervise bachelor and master student projects;
- present data at local, national and international scientific meetings.
What do we require?You are a highly motivated, ambitious student with a Master degree in Molecular Life Sciences (project 1), Neuroscience (project 2), or equivalent. Analytical and theoretical skills as well as experimental talent are essential. A background in cellular imaging / molecular biology (project 1) or cellular neuroscience (project 2) is an advantage.
You are an enthusiastic person with appreciable communication skills, who communicates very constructively in a team-based environment, and with excellent writing skills in English. You are passionate about science and interested in signaling pathways that drive synaptic plasticity.
You like a challenge and are motivated to work in an interdisciplinary environment. You are a team player and a nice colleague with good problem-solving skills. You have a high intrinsic motivation and aptitude for fundamental research (reflected by your CV).
Our offer
We offer a temporary contract for 38 hours per week, preferably starting on 1 November 2024 for the duration of 4 years (initial contract will be for a period of 18 months and after satisfactory evaluation it will be extended for a total duration of 4 years). This should lead to a dissertation (PhD thesis). We will draft an educational plan that includes attendance of courses and (international) meetings. We also expect you to assist in teaching undergraduates and master students.
Based on a full-time appointment (38 hours per week) the gross monthly salary will range from € 2.770 in the first year to €3.539 (scale P) in the last year. This is exclusive 8% holiday allowance and 8.3% end-of-year bonus. A favourable tax agreement, the '30% ruling', may apply to non-Dutch applicants. The Collective Labour Agreement of Dutch Universities is applicable.
