Research Scientist Biophysical Characterization

3 maanden geleden


Nijmegen, Nederland Byondis Voltijd

Application deadline:_

13-10-2024
- Expected start date:_

ASAP
- Location:_

Nijmegen
- Company homepage:_
- Office address:_

Microweg 4, 6545CM Nijmegen

Byondis is an independent Dutch biopharmaceutical company, based in Nijmegen, that focuses on developing innovative medicines against cancer and autoimmune diseases. We are driven by one goal: to develop new treatments to improve the standard of care for patients.

**Research Scientist Biophysical Characterization**

**The role**

The department of Analytical Development and Quality Control (ADQC) plays a key role in Byondis’ development and manufacturing, as biotechnology-derived medicinal products cannot be designed, improved or used without extensive and accurate analytical measurements. Therefore, we take pride in providing high quality analytical information to ensure the safety and efficacy of our innovative products for patients.

ADQC is responsible for all analytical testing to enable the development, manufacture and use of biotherapeutic products for toxicological assessments and clinical trials. The department develops, qualifies and applies a broad panel of analytical methods to characterize new biological entities such as monoclonal antibodies and antibody drug conjugates.

For this purpose, a range of sophisticated analytical technologies is available, ranging from chromatography, electrophoresis, mass spectrometry, spectroscopy, microbiology to cell-based assays. ADQC comprises a diverse and multidisciplinary team of about 45 people with in-depth knowledge and experience in various analytical areas. We always seek collaboration and are determined to provide answers rather than test results.

The Research Scientist Biophysical Characterization will be part of the Extended Analytical Characterization Team within Analytical Development that is responsible for the in-depth, non-GMP, characterization of all molecules in CMC development at Byondis, meaning proteins (monoclonal antibodies), small molecules (excipients) and the combination of both: antibody-drug conjugates. Activities include: analytical development and execution of biophysical methods, including spectroscopy (e.g. CD, FT-IR, fluorescence), thermal analysis (e.g. DSC) and light scattering (e.g. DLS, mass photometry), for a variety of purposes, including support of process development, comparability studies, qualification of reference materials, etc. Next to that, providing troubleshooting support and addressing scientific questions arising during the early development of Byondis’ therapeutic products make up an integral part of our activities. Lastly, keeping up with developments in the field through surveying literature as well as internal and external interactions, is important.

**Core competences**:

- Taking ownership of activities with a mindset focused on precision and quality of your own, as well as the team's, work involving data acquisition, adequate data analysis and clear and concise reporting.
- A natural team player with an attitude to collaborate and communicate.
- Being flexible to act in a fast-changing and demanding environment.
- You are result-oriented and use proactivity and creativity as your methodology to find solutions.
- You are self-motivated, which enables you to work with a high degree of independence.

**Your profile**

Your letter of motivation and CV should show that you have:

- An M.Sc. degree in analytical sciences, (bio)chemistry, etc.;
- Demonstrable and relevant experience in a comparable position and/or work environment;
- Experience with the development and execution of biophysical characterization methods for biopharmaceutical products;
- Up-to-date knowledge on biophysical analytical approaches for protein characterization;
- Excellent command of the English language, both verbally and in writing;
- Willingness to continuously develop and expand your skills, knowledge and expertise and support your direct colleagues in doing the same.

**Benefits and well being**

Besides a competitive salary, we offer you a dynamic working environment at our state of the art campus in Nijmegen. Our values as integrity, authenticity, entrepreneurship, quality and trust are very highly regarded. We also offer an excellent pension scheme, 30 days annual holidays based on a fulltime position and we organize several company events throughout the year.

**Join Byondis and create the future you want, today**

Contract hours: 32-40 hrs/week, preferably fulltime

Salary: depending on experience

Location: Nijmegen

Applicants must be nationals of a Member State of the European Union or hold a valid work permit for the European Union.



  • Nijmegen, Gelderland, Nederland The Kraft Heinz Company Voltijd

    About the RoleWe are seeking a talented and motivated Sensory Research Scientist to join our Consumer & Sensory Research team in Nijmegen. As a Sensory Research Scientist, you will play a key role in understanding how consumers perceive and experience our products.The ideal candidate will have strong analytical skills, excellent communication abilities, and...


  • Nijmegen, Gelderland, Nederland Max Planck Institute for Psycholinguistics Voltijd

    We are seeking a highly skilled Research Scientist to join our team at the Max Planck Institute for Psycholinguistics. This exciting opportunity will involve working on a cutting-edge project in sociogenomics, exploring the complex relationships between genetics, language development, and behavior.The successful candidate will co-lead a project investigating...


  • Nijmegen, Nederland Radboudumc Voltijd

    1 year with a possible extension of 1 year **Are you a junior scientist or a postdoc specializing in PBPK modeling? Join us and contribute to safer, more effective treatments for children and pregnant women. Make a significant impact on global health with our enthusiastic research team!** Many medications for children and pregnant women are often prescribed...

  • Research Technician

    2 weken geleden


    Nijmegen, Nederland TropIQ Health Sciences Voltijd

    **Position**: Research Technician **Location**: Nijmegen, Netherlands **Vacancy for a Research Technician** TropIQ Health Sciences is looking for a flexible, passionate, and detail-oriented research technician to join our team of scientists focused on combatting vector-borne diseases, particularly malaria. By combining state-of-the-art technologies,...


  • Nijmegen, Gelderland, Nederland Kraft Heinz Company Voltijd

    We are seeking a highly motivated and experienced Microbiology Bachelor/Master student to join our R&D team as a Natural Preservation Intern in Nijmegen, Gelderland, NL.Job DescriptionThe successful candidate will be responsible for researching natural antimicrobials to enable replacement of chemical preservatives in Kraft Heinz sauces. This role involves...


  • Nijmegen, Nederland Byondis Voltijd

    Application deadline:_ 04-11-2024 - Expected start date:_ ASAP - Location:_ Nijmegen - Company homepage:_ - Office address:_ Microweg 4, 6545CM Nijmegen **Research Analyst protein engineering and expression** Byondis is an independent Dutch biopharmaceutical company, based in Nijmegen, that focuses on developing innovative medicines against cancer and...


  • Nijmegen, Nederland Byondis Voltijd

    Application deadline:_ 04/11/2024 - Expected start date:_ ASAP - Location:_ Nijmegen - Company homepage:_ - Office address:_ Microweg 4, 6545CM Nijmegen **DSP Researcher Downstream Processing** Byondis is an independent Dutch biopharmaceutical company, based in Nijmegen, that focuses on developing innovative medicines against cancer and autoimmune...


  • Nijmegen, Nederland Adver Online Voltijd

    The Director HFML-FELIX position offers an exceptional opportunity to lead a prestigious research institute, driving innovation and excellence in the field of molecular and materials science.About HFML-FELIXHFML-FELIX is one of ten NWO-I research institutes, part of the National Dutch Roadmap and the European Strategy Forum on Research Infrastructures...


  • Nijmegen, Nederland Radboudumc Voltijd

    1 year with a possible extension of 1 year **_Are you passionate about improving drug safety for children and pregnant women? Join our team as a junior researcher / postdoc to translate model-informed dosing recommendations into (inter)national guidelines and collaborate with the MADAM group._** Many drugs in children and pregnant women are prescribed...

  • Sensory Panel Leader

    1 maand geleden


    Nijmegen, Nederland MMR Research Worldwide LTD Voltijd

    **Sensory Panel Leader MMR / Kraft Heinz - Nijmegen, NL** MMR is a global leader in guiding innovation for clients within the food, drink and personal care sectors. We advise many iconic global brands, as well as up-and-coming innovators. Our culture is vibrant, fast paced, yet friendly and supportive. Our work practices embody both scientific rigor and...

  • Sensory Panel Leader

    1 maand geleden


    Nijmegen, Nederland MMR Research Worldwide LTD Voltijd

    Sensory Panel Leader MMR / Kraft Heinz– Nijmegen, NL Do you have sensory panel leading and sensory project management leading experience? Are you looking for your next step within your sensory career? Apply now to join the team at MMR! MMR is a global leader in guiding innovation for clients within the food, drink and personal care sectors. We advise...

  • Head of Chemistry

    6 maanden geleden


    Nijmegen, Nederland Tagworks Pharmaceuticals Voltijd

    **The company** Headquartered in Nijmegen, The Netherlands, Tagworks Pharmaceuticals is a dynamic biotech company with strong backing from prominent US and European investors. Specializing in proprietary in vivo click chemistry, Tagworks is committed to improving the effectiveness and reducing the toxicity of systemic cancer treatments. Operating at the...


  • Nijmegen, Gelderland, Nederland Radboud University Voltijd

    Job Description:We are seeking a highly motivated and skilled postdoctoral researcher to contribute to the Oncode Accelerator Growth Fund Project. As part of this large consortium, you will be working closely with various groups in the Netherlands to innovate and accelerate the development of new cancer therapies.Key Responsibilities:Apply state-of-the-art...

  • Director HFML-FELIX

    7 dagen geleden


    Nijmegen, Gelderland, Nederland Adver Online Voltijd

    The positionAs scientific and general director you are responsible for the scientific mission and national scientific programme of the institute and partnership. You report to the Governing Board of the partnership. You have a proven track record as an internationally recognized scientist in the field of molecular or materials science and are capable of...


  • Nijmegen, Nederland Radboudumc Voltijd

    4 years **_Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with the lowest 5-year survival among all solid tumors. Cancer-associated fibroblasts (CAFs) promote tumor cell proliferation and prevent chemotherapy and immune cells from attacking the tumor, leading to poor patient outcome. Novel approaches to kill these CAFs are therefore...


  • Nijmegen, Nederland Radboudumc Voltijd

    2 years with a possible extension up to 5 years **_We are seeking a highly motivated and talented senior associate researcher (Junior lab Leader) to join our team in the development of functional organoids and study physiology of the retina. Would you like to join our team at the Department of Ophthalmology at Radboud University Medical Center, a global...


  • Nijmegen, Nederland Radboudumc Voltijd

    Colorectal cancer (CRC) is the third most common cancer worldwide, with rising incidence rates. Recent studies have revealed that bacterial oncotoxins—carcinogenic compounds produced by gut bacteria—may play a significant role in CRC development. This project funded by the Dutch Digestive Diseases Foundation (MLDS), led by Dr. Annemarie Boleij at...


  • Nijmegen, Nederland Radboudumc Voltijd

    Multiple Myeloma (MM) is the 2nd most common haematological malignancy and is characterized by monoclonal expansion of plasma cells in the bone marrow. These plasma cells produce monoclonal immunoglobulins (M-proteins) that provide a unique cancer-biomarker. M-protein diagnostics is crucial for diagnosis, risk-stratification and follow-up of MM patients....

  • Product Developer

    3 maanden geleden


    Nijmegen, Nederland DFE Pharma GmbH & Co. KG Voltijd

    Did you know that you already know us? Almost every second tablet which is on the global market contains our products. This demands great entrepreneurial power so that we are always looking for people who take ownership and are not afraid of accountability. Now it is your chance to join! We are looking for a pro-active, result-driven product developer in our...

  • Product Developer

    3 maanden geleden


    Nijmegen, Nederland DFE Pharma GmbH & Co. KG Voltijd

    Did you know that you already know us? Almost every second tablet which is on the global market contains our products. This demands great entrepreneurial power so that we are always looking for people who take ownership and are not afraid of accountability. Now it is your chance to join! We are looking for a pro-active, result-driven product developer in our...