Postdoc Bioinformatics at Neuro-oncology Research Group
1 week geleden
**About the project**:
In glioblastoma treatment, the most frequent and most lethal malignant primary brain tumor, fully informed decisions are hindered by a phenomenon known as pseudoprogression. During and after treatment, new MRI findings can either signal progression and poor prognosis, or pseudoprogression and more favorable prognosis. Based on imaging alone, it is often difficult to distinguish true progression from pseudoprogression, possibly delaying treatment decisions and impacting survival and quality of life. Liquid biopsies may offer a solution. In the **PREDICT**study, we aim to further develop our blood platelet RNA-based platform into a highly accurate test that is ready for a clinical intervention study. Additionally, similar research is being conducted on pseudoprogression and radionecrosis in brain metastasis and over 2000 RNA samples have already been collected from various other tumor types.
**About the role**:
As a postdoctoral researcher, you will be involved the preprocessing and downstream analysis of RNA-seq data, measured in ~300 patients at multiple time points. Your tasks include:
- Data preprocessing, RNA-seq data mapping and quality control, differential expression and machine learning development, integration and validation;
- Implementation of bioinformatic normalization
- and correction methods;
- Analysis of previously generated data sets (RNA-seq data of >2000 samples readily available);
- Collaborating with, and supervising the PhD student currently working on the project;
- Publishing your findings in high-impact journals;
**Profile**:
We are looking for an enthusiastic PhD graduate in bioinformatics who is analytically strong and is experienced with RNA-seq analysis. Specifically you have:
- A completed PhD in bioinformatics, preferably in the field of RNA-seq;
- Experience in statistics and data science;
- Advanced programming skills, preferably R and linux/bash;
- Interest in noninvasive tests for cancer therapy monitoring;
- Good communication skills and eager to collaborate;
- Good level of English, both in speaking and writing.
**Our offer**:
- A flying start to your career in scientific research;
- Plenty of room for your drive to shape tomorrow's healthcare;
- A contract for 28 to 36 hours for 12 months (extension possible for a maximum of 2,5 years);
- Salary scale 10: € 3.493 to € 5.504 gross per month based on full-time employment (depending on education and experience);
- In addition to a good basic salary, we offer 8.3% end-of-year bonus. Calculate your net salary here;
- Holiday hours: 186,4 per year for fulltime and a possibility to save additional hours.
- Pension accrual with BeFrank, a modern, comprehensible and fairly priced pension.
- For >7 km each way, 100% reimbursement for public transport travel costs and, for private transport, €0.18 per km up to a maximum of 40 km each way.
- Do you prefer walking or cycling? Take advantage of our good bike scheme. Moreover, you will receive a reimbursement of €0.18 per km.
**About the workplace**:
You will be working in the **Neuro-Oncology Research Group** (NRG), led by prof. David Noske, neurosurgeon. The group has recently moved to the new Research & Diagnostics Center and contains multiple postdocs and PhD students investigating gliomas. The NRG is embedded in Cancer Center Amsterdam and Brain Tumor Center Amsterdam. The group has multiple external collaborations, such as Antoni van Leeuwenhoek / Netherlands Cancer Institute, as well as international collaborations, such as England for the PREDICT study.
Amsterdam UMC Research BV supports non-profit scientific research. In doing so, we provide researchers with everything they need to excel. Our principal investigators (PIs) and project leaders offer support in the field of project management, finance and human resources. In medical scientific research projects, legal support is also provided.
Watch the video to find out more.
**Let's meet**:
A reference check, screening and hiring test may be part of the procedure. Read here whether that applies to you. If you join us, we ask you for a VOG (Certificate of Good Conduct).
Acquisition in response to this vacancy is not appreciated.
-
Postdoc Neuro-immunology
3 maanden geleden
Amsterdam Zuid, Nederland Amsterdam UMC Voltijd**About the project**: This collaborative project is embedded in the Amsterdam Institute for Infection and Immunity and is funded by the ADORE Foundation. **ADORE**, which stands for **A**mster**D**am **O**ncology and Neuroscience **RE**search, is a collaborative effort between the Cancer Center Amsterdam and Amsterdam Neuroscience, comprising a total of...
-
Postdoc Datamanager Biodora
2 maanden geleden
Amsterdam Zuid, Nederland Amsterdam UMC Voltijd**Wat ga je onderzoeken**: Binnen Amsterdam UMC gaan patiëntenzorg en wetenschappelijk onderzoek hand in hand. Alle patiënten die in het kader van diagnostiek en behandeling onze poli bezoeken, worden gevraagd om deel te nemen aan wetenschappelijke onderzoeken om de diagnose en behandeling van kanker en neurodegeneratieve ziekten te verbeteren. Zowel voor...
-
Phd Position in Bioinformatics of The Microbiome
5 maanden geleden
Amsterdam, Nederland Universiteit van Amsterdam VoltijdPhD Position in Bioinformatics of the Microbiome **Faculteit/Dienst**:Faculteit der Natuurw., Wiskunde & Informatica**Opleidingsniveau**:Master**Functie type**:Promotieplaats**Sluitingsdatum**:29.09.2024**Vacaturenummer**:13334- Are you fascinated by the microbiome and its interaction with the human host? Microbiome research has flourished in the last...
-
Postdoc at Crispr Center
2 maanden geleden
Amsterdam Zuid, Nederland Amsterdam UMC Voltijd**About the project**: Pancreatic cancer remains one of the most challenging cancers to treat, largely due to its dense fibrotic environment, which hinders the efficacy of conventional therapies. This collaborative project, conducted in partnership with the biopharmaceutical company iOnctura, focuses on exploring the biological mechanisms underlying the...
-
Phd and Postdoc Positions at Vusec
7 maanden geleden
Amsterdam Zuid, Nederland Vrije Universiteit Amsterdam Voltijd**Your function**: VUSec performs world-leading research in the broad area of systems security. We work on attacks, defenses, reverse engineering, and formal verification of security. We cover all major areas where security is important, especially software security, hardware security, and network security. We love to work on low-level stuff, for example...
-
Postdoc Position in Predicting and Designing
4 maanden geleden
Amsterdam, Nederland Universiteit van Amsterdam VoltijdPostdoc Position in Predicting and Designing Olfactory Molecules **Faculteit/Dienst**:Faculteit der Natuurw., Wiskunde & Informatica**Opleidingsniveau**:Gepromoveerd**Functie type**:Wetenschappelijk Personeel**Sluitingsdatum**:23 september 2024**Vacaturenummer**:13386 - This 18 months postdoc position is one of several collaborative cross-disciplinary...
-
Phd Position: Software Architecture for
7 maanden geleden
Amsterdam Zuid, Nederland Vrije Universiteit Amsterdam Voltijd**Your function**: With the current hype around generative AI and large language models (LLMs), one approach to partly mitigate the lack of common-sense reasoning of systems relying solely on machine learning (ML) is **neuro-symbolic AI**, i.e., synergistically combining the neural AI tradition via deep learning and artificial neural networks and the...
-
Postdoctoral Researcher in Microbiome Analysis of
4 maanden geleden
Amsterdam, Nederland Universiteit van Amsterdam VoltijdPostdoctoral Researcher in Microbiome Analysis of the Soil-plant-gut-health Axis **Faculteit/Dienst**:Faculteit der Natuurw., Wiskunde & Informatica**Opleidingsniveau**:Gepromoveerd**Functie type**:Researcher**Sluitingsdatum**:31.10.2024**Vacaturenummer**:13418- In the NWO-KIC project MicroHealth, we study the role of the microbiome in the relationship...
-
Postdoctoral Researcher
2 maanden geleden
Amsterdam, Nederland Antoni van Leeuwenhoek Ziekenhuis VoltijdJouw functie The Netherlands Cancer Institute and the Antoni van Leeuwenhoek Hospital form a comprehensive cancer center, combining a research facility and a hospital under one roof in a single, independent organization. Research is focused on improving cancer treatment through imaging and molecular diagnostics, new medicine, immunotherapy, improved...
-
Postdoc in Medicinal and Radiopharmaceutical Chemistry
4 dagen geleden
Amsterdam Zuid, Nederland Amsterdam UMC Voltijd**About the project**: We are looking for a highly motivated and enthusiastic postdoctoral fellow at the **Tracer Center Amsterdam** (TCA) to work on a collaborative project focusing on the development of Positron Emission Tomography (PET) tracers for imaging neuroinflammation. The position will be placed in an interdisciplinary research setting that brings...
-
Postdoc: Nanophotonics and Quantum Physics with
7 maanden geleden
Amsterdam Oost, Nederland AMOLF Voltijd**Postdoc: Nanophotonics and quantum physics with electrons and light**: **Work Activities**: Did you know high-energy electrons can serve as efficient sources of optical excitation of matter? Our group has developed cathodoluminescence microscopy, in which we use 1-30 keV electrons in a scanning electron microscope (SEM) to excite nanomaterials. The...
-
Dbi2 Postdoc Netherlands Institute for Neuroscience
2 maanden geleden
Amsterdam, Nederland Koninklijke Nederlandse Akademie van Wetenschappen Voltijd**Location**:Amsterdam **Max hours per week**:38 **Max salary**:5278,00 **Duration of agreement**:1 - 3 years **Postdoc in social rodent neuroscience: understanding social and brain dynamics of multiple individuals** Both human and rodents live in complex environments that include the necessity to interact with other conspecifics. To better understand how...
-
Postdoc in Rodent Social Neuroscience
7 maanden geleden
Amsterdam, Nederland Koninklijke Nederlandse Akademie van Wetenschappen Voltijd**Location**:Amsterdam **Max hours per week**:38 **Max salary**:5090,00 **Duration of agreement**:1 - 3 years **Postdoc in social rodent neuroscience: understanding social and brain dynamics of multiple individuals** Both human and rodents live in complex environments that include the necessity to interact with other conspecifics. To better understand...
-
Associate Scientist Oncology Discovery
2 maanden geleden
Zuid-Holland, Nederland Unique VoltijdWat ga je precies doen Join our Oncology Discovery team as an associate scientist, where your expertise will play a pivotal role in developing groundbreaking therapies. In this dynamic 12-month contractor position based in Mechelen, Belgium, you'll tackle the exhilarating challenge of executing cellular assays to advance drug discovery. Your work will...
-
Postdoc: Chaperone-guided Formation of Single
7 maanden geleden
Amsterdam Oost, Nederland AMOLF Voltijd**Postdoc: Chaperone-guided formation of single protein complexes**: **Work Activities**: Do you want to discover how multi-protein assemblies are produced without error? The aim of this project is to reveal this vital cellular process at the single-molecule level. Our research group has been at the vanguard of studying chaperone-protein interactions using...
-
Research Analist Neuro- Immunologie
3 maanden geleden
Amsterdam Zuid, Nederland Amsterdam UMC Voltijd**Wat ga je onderzoeken**: Een van de meest urgente uitdagingen bij de behandeling van de hersenziekte multipele sclerose (MS) is het vinden van een therapeutische strategie die neuro-inflammatie stopt en tegelijkertijd progressieve neurodegeneratie tegenhoudt. In dit project onderzoeken we de rol van de chemokine CXCL12 en receptoren in MS en worden nieuw...
-
Postdoc: Environmental Justice in Scaling
2 maanden geleden
Amsterdam Zuid, Nederland Vrije Universiteit Amsterdam Voltijd**Your function**: In this exciting postdoc position, you will conduct applied research to address a major knowledge gap on how to scale Nature Based Solutions in an equitable and just way. Using political sciences and economics, you will independently develop research activities in our FairNature project, funded by Biodiversa+ under the call “Nature-Based...
-
Postdoc in Biophysics: Single-cell Tracking in Organoids
4 weken geleden
Amsterdam Oost, Nederland AMOLF Voltijd**Work Activities**: **Summary -** In this project, you will use advanced 3D imaging and AI-driven cell tracking to reveal the remarkable self-organization of cells within intestinal organoids. Using a biophysics approach, you will study how stem cells move, grow, divide, and differentiate into specific functional cell types, and hence reveal how functional...
-
Postdoc Political Masculinities in The European
3 maanden geleden
Amsterdam, Nederland Universiteit van Amsterdam VoltijdPostdoc Political Masculinities in the European Parliament **Faculteit/Dienst**:Faculteit der Maatschappij - & Gedragswetenschappen**Opleidingsniveau**:Gepromoveerd**Functie type**:Postdoc**Sluitingsdatum**:31 October 2024**Vacaturenummer**:13472- The Department of Political Science at the University of Amsterdam (UvA) is looking for a postdoctoral...
-
Postdoc Position in Fungal Ecology
4 maanden geleden
Amsterdam Zuid, Nederland Vrije Universiteit Amsterdam Voltijd**Jouw functie**: **Job description** Arbuscular mycorrhizal fungi (AMF) form one of the most widespread terrestrial symbiosis on earth with the roots of host plants, known broadly as the mycorrhizal symbiosis. AMF can connect with one another and with multiple plants, forming large underground common mycorrhizal networks where carbon and nutrients are...