Postdoc in Biophysics: Single-cell Tracking in Organoids

**PhD in biophysics: Single-cell Tracking in Organoids**: **Work Activities**: **Summary -** In this project, you will use advanced 3D imaging and AI-driven cell tracking to reveal the remarkable self-organization of cells within intestinal organoids. Using a biophysics approach, you will study how stem cells move, grow, divide, and differentiate into...

**Work Activities**: **Summary -** In this project, you will use advanced 3D imaging and AI-driven cell tracking to reveal the remarkable self-organization of cells within intestinal organoids. Using a biophysics approach, you will study how stem cells move, grow, divide, and differentiate into specific functional cell types, and hence reveal how functional...

**Postdoc: Discovering CAR T cell biophysics with single-molecule TIRF microscopy**: **Work Activities**: Notably, a complex spatio-temporal dynamics is thought to be central to CAR T cell activation, but is difficult to measure and hence remains poorly understood. That the activation relies on the movement and association of many receptors and accesory...

**Postdoc: Single-molecule microscopy of checkpoint therapeutic action on T cells**: **Work Activities**: As postdoc member of the REPRESSIT consortium coordinated the Physics of Cellular Interactions group headed by Dr. Kristina Ganzinger, you will work on developing a new type of cancer therapeutic (checkpoint inhibitor) in a biophysical project right at...

**Work Activities**: Notably, a complex spatio-temporal dynamics is thought to be central to CAR T cell activation, but is difficult to measure and hence remains poorly understood. That the activation relies on the movement and association of many receptors and accesory proteins in an orchestrated manner is a fascinating notion. By addressing this question...

We are seeking a highly motivated, self-driven postdoctoral researcher in bioinformatics to the Kool group at the Princess Máxima Center for pediatric oncology. Our group studies the genomics and epigenomics of pediatric brain tumors and how to translate findings from these studies into novel therapies. Do you want to contribute to the Princess Máxima...

**Postdoc: Chaperone-guided formation of single protein complexes**: **Work Activities**: Do you want to discover how multi-protein assemblies are produced without error? The aim of this project is to reveal this vital cellular process at the single-molecule level. Our research group has been at the vanguard of studying chaperone-protein interactions using...

**Work Activities**: Do you want to discover how multi-protein assemblies are produced without error? The aim of this project is to reveal this vital cellular process at the single-molecule level. Our research group has been at the vanguard of studying chaperone-protein interactions using optical tweezers, which allows one to follow the movements and folding...

**PhD student: Single-molecule biophysics of the ubiquitin motor Cdc48/p97**: **Work Activities**: **Questions -** Ubiquitin is central to a broadly important regulatory system within cells, which controls anything from protein degradation to membrane remodeling and DNA replication regulation. Cdc48 performs these tasks by disassembling protein complexes,...

We are seeking a highly motivated PhD researcher to join our team at the Vrije Universiteit Amsterdam.Job DescriptionThis PhD position is part of the EU-funded Marie Skłodowska Curie Doctoral Network (DN) "MeChaNiSM", which brings together 8 partners and supports up to 15 PhD students in the field of nucleic acids chemistry and biophysics.The successful...

**The single-molecule dynamics and biophysics of the ubiquitin motor Cdc48/p97**: **Work Activities**: **Questions -** Ubiquitin is central to a broadly important regulatory system within cells, which controls anything from protein degradation to membrane remodeling and DNA replication regulation. Cdc48 performs these tasks by disassembling protein...

**PhD in Biophysics: Chaperone-guided formation of single protein complexes**: **Work Activities**: Do you want to discover how multi-protein assemblies are produced without error? The aim of this project is to reveal this vital cellular process at the single-molecule level. Our research group has been at the vanguard of studying chaperone-protein...

**Postdoc: The real-time dynamics of single ribosomes**: **Work Activities**: **Questions -** According to textbooks, ribosomes work individually to produce proteins. However, recent insights from our lab and others show multiple ribosomes cooperate as they translate mRNA. This cooperation may well be essential to produce multi-protein complexes faithfully....

Stem cells are valuable tools for modelling human and animal diseases, as well as a source of differentiated cells for use in regenerative medicine and drug discovery. An essential prerequisite for using stem cells in medicine is the assurance of genetic stability. We are looking for a postdoc to be involved in research on the pathogenesis of stem cell...

Company OverviewAMOLF is a research institute at the forefront of studying complex forms of matter. Our team performs leading fundamental research on the physics of these materials, creating new functional materials in partnership with academia and industry.Salary and BenefitsThe estimated salary for this position is approximately €27,810 per year, based...

**Work Activities**: **Questions -** Ubiquitin is central to a broadly important regulatory system within cells, which controls anything from protein degradation to membrane remodeling and DNA replication regulation. Cdc48 performs these tasks by disassembling protein complexes, extracting proteins from membranes, unfolding misfolded proteins, and by...

**Work Activities**: **Questions -** According to textbooks, ribosomes work individually to produce proteins. However, recent insights from our lab and others show multiple ribosomes cooperate as they translate mRNA. This cooperation may well be essential to produce multi-protein complexes faithfully. In our group, we aim to elucidate the highly diverse and...

**About the project**: This collaborative project is embedded in the Amsterdam Institute for Infection and Immunity and is funded by the ADORE Foundation. **ADORE**, which stands for **A**mster**D**am **O**ncology and Neuroscience **RE**search, is a collaborative effort between the Cancer Center Amsterdam and Amsterdam Neuroscience, comprising a total of...

**About the project**: As a research technician, you will support the researchers of the Ocular Angiogenesis Group of the Department of Ophthalmology. We focus on vascular diseases of the retina, such as diabetic retinopathy and macular degeneration. In our research, you will work with vascular organoids derived from patient-specific stem cells (iPSCs)....

We are seeking a highly motivated and talented Postdoctoral Researcher to join our team and contribute to our ongoing projects in computational genomics. **The Position** We are seeking a highly motivated computational biologist with a PhD in genomics, cancer biology, or related fields, ideally with experience in single-cell genomics and machine learning....