Postdoc Computational Genomics

1 maand geleden


Utrecht Oost, Nederland Prinses Máxima Centrum Voltijd

We are seeking a highly motivated and talented Postdoctoral Researcher to join our team and contribute to our ongoing projects in computational genomics.

**The Position**

We are seeking a highly motivated computational biologist with a PhD in genomics, cancer biology, or related fields, ideally with experience in single-cell genomics and machine learning. The project will be focused on analyzing and interpreting combined single-cell DNA/RNA sequencing data of patient samples, which we generate in our group. For this, we use in-depth mutational analyses, multimodal data integration and machine learning. In addition, we have developed innovative experimental setups, including next-generation CRISPR editing, to validate our findings and obtain mechanistic insights. You will be supported by a strong bioinformatics and wet-lab team.

**Qualifications**
- PhD in genomics, cancer biology, bioinformatics or a related field
- Strong data analysis skills (Bash, R and Python)
- Proven research productivity with publications in high-impact journals
- Experience in development of analysis workflows and/or pipelines is a pre (Snakemake and/or Nextflow)
- Excellent communication and teamwork skills
- Willingness to collaborate and mentor PhD students

***Our job offer**

We offer you a full-time position (based on 36 hours a week) in a very stimulating and interactive research environment with professional development and career advancement opportunities. You will have access to cutting-edge research facilities. We also offer you a collaborative and supportive work environment with mentorship from experienced researchers. The contract will be initially for one year, with the possibility to extend upon satisfaction. Your gross monthly salary will depend on your experience and background, starting in scale 60 with 8,33% gross monthly salary holiday allowance and 8,33 % end-of-year bonus. The Princess Máxima Center operates according to the collective labor agreement ‘cao algemene ziekenhuizen’.

**The Boxtel group**

In our research group we combine cutting-edge molecular biology with advanced genomics to investigate cancer etiology, disease mechanisms, and the long-term effects of cancer treatments. Our pioneering single-cell genomics methods allow us to explore cellular heterogeneity and dynamics in unprecedented detail.

Cancer treatments have improved survival rates, but understanding the long-term effects on survivors, especially in childhood cancer, remains a major challenge. These effects often mimic accelerated aging, and stem cells are likely key targets. While epidemiological studies have identified risk factors, molecular and cellular data are still lacking. This is where our lab steps in, using single-cell omics and advanced bioinformatics to reveal the molecular mechanisms behind these effects, aiming to inform safer therapies.

***The Princess Máxima Center**

The Princess Máxima Center for Pediatric Oncology is an integrated hospital and research institute, which integrates healthcare, research and education on pediatric cancer, in a single location in Utrecht. Our institute aims to provide the highest level of care for all children with cancer, with optimal quality of life. The center brings together the best possible care and scientific research, creating a unique interdisciplinary institute for pediatric oncology in Europe.

**Contact**
- an up-to-date resume/CV.
- a motivation letter of max. 1 page including description of your qualifications.
- contact information of 2-3 references.

The vacancy will close on December 31. For more information, please contact Dr. Ruben van Boxtel.
- Acquisitie naar aanleiding van deze vacature wordt niet op prijs gesteld._

**Details**:
- 36 hours per week- FWG: 60
- Min. €3.923;
- max. €5.746,
- **Contactpersoon**:
Ruben van Boxtel



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