Postdoctoral Researcher in Molecular Hematology

3 weken geleden


Utrecht, Nederland Prinses Máxima Centrum Voltijd

We are seeking a highly motivated and talented Postdoctoral Researcher to join our team and contribute to our ongoing projects in molecular hematology.

**Research focus**

You will play a key role in the design and implementation of _in vitro_ culture models using primary human hematopoietic cells, with a particular emphasis on single-cell genomics technologies. Additionally, experience with CRISPR technology will be highly valued as we explore gene editing approaches for functional studies in hematopoietic cells, particularly in the context of cancer treatment-associated late effects.

**Responsibilities**
- Design and optimize in vitro culture models using primary human hematopoietic cells to study the consequences of cancer treatment.
- Perform single-cell genomics experiments to characterize the molecular and cellular changes induced by chemotherapy exposure in hematopoietic cells.
- Utilize CRISPR technology for gene editing and functional studies in hematopoietic cells, with a focus on understanding the underlying mechanisms of treatment-associated late effects.
- Analyze and interpret experimental data, and contribute to manuscript preparation and publication.
- Collaborate with team members and contribute to a vibrant research environment focused on hematological disorders and cancer treatment outcomes.

**Qualifications**
- PhD in Molecular Biology, Cell Biology, Hematology, or a related field.
- Extensive experience in setting up and optimizing in vitro culture models using primary human hematopoietic cells.
- Extensive experience in flow cytometry.
- Proficiency in single-cell genomics techniques, including library preparation and data analysis, with a focus on hematological contexts.
- Strong molecular biology skills, with experience in CRISPR technology preferred.
- Excellent organizational, communication, and interpersonal skills.
- Ability to work independently and collaboratively in a multidisciplinary research environment focused on hematological disorders and cancer treatment outcomes.
- Affinity with computational analyses is preferred.

**Our job offer**

We offer you a full-time position (based on 36 hours a week) in a very stimulating and interactive research environment. You will also have the opportunity to actively collaborate with various research groups at the Princess Máxima Center. You will have access to state-of-the-art research facilities and resources and opportunities for professional development and career advancement in the field of molecular hematology. We also offer you a collaborative and supportive work environment with mentorship from experienced investigators. The contract will be initially for one year, with the possibility to extend upon satisfaction. Your gross monthly salary will depend on your experience and background, starting in scale 60 with 8,33% gross monthly salary holiday allowance and 8,33 % end-of-year bonus. The Princess Máxima Center operates according to the collective labor agreement ‘cao algemene ziekenhuizen’.

Previous postdoctoral researchers in our lab have been highly successful in obtaining prestigious personal grants, highlighting our commitment to fostering the career development of our team members. As part of our lab, you will have access to unique mentorship opportunities and support to advance your career in biomedical research.

**The Boxtel group**

We are a dynamic and innovative biomedical research group focused on advancing our understanding of hematological disorders and developing novel therapeutic strategies. Our lab combines cutting-edge molecular biology techniques with state-of-the-art genomics approaches to dissect the molecular mechanisms underlying hematopoiesis, disease pathogenesis, and the late adverse effects of cancer treatment. We have pioneered methods to study the genomes of single hematopoietic stem cells, allowing us to delve deep into cellular heterogeneity and dynamics to achieve our research goals.

While much cancer research is focused on curing the disease, the mechanisms underlying treatment-associated late effects in survivors, particularly in hematological contexts, remain unclear. Cancer treatment has improved gradually in recent decades, leading to an increase in the number of survivors. However, late adverse effects of cancer treatment, including those affecting hematopoietic stem cells, will likely become one of the biggest future challenges in cancer research.

**The Princess Máxima Center**

The Princess Máxima Center for Pediatric Oncology is an integrated hospital and research institute, which integrates healthcare, research and education on pediatric cancer, in a single location in Utrecht. Our institute aims to provide the highest level of care for all children with cancer, with optimal quality of life. The center brings together the best possible care and scientific research, creating a unique interdisciplinary institute for pediatric oncology in Europe.

**Contact**
- an up-to-date



  • Utrecht, Nederland UMC Utrecht Voltijd

    AI Lab "AI for Molecular Medicine" is seeking a postdoctoral researcher to explore immune checkpoint inhibitor (ICI) resistance in melanoma. You'll use AI-driven data analysis and spatial transcriptomics to contribute to groundbreaking research.**Elke dag de zorg en de gezondheid van mensen verbeteren**Goede arbeidsvoorwaarden**Jezelf continu blijven...


  • Utrecht, Nederland Prinses Máxima Centrum Voltijd

    In the Clevers group at the Princess Máxima Center for pediatric oncology, we are looking for a highly motivated postdoctoral researcher with immuno-oncology expertise. **The project** We are looking for an enthusiastic postdoc with immuno-oncology expertise. We have several ongoing projects that focus on immunotherapy using pediatric cancer organoid...


  • Utrecht Binnenstad, Nederland Universiteit Utrecht Voltijd

    We are seeking to hire a highly motivated, driven, and talented postdoctoral researcher to participate in the project “Memory access in language (MEMLANG): how we store and retrieve linguistic information” led by Jakub Dotlacil. The job is offered for the duration of 3 years and will be carried out at the Institute for Language Sciences (ILS) at Utrecht...

  • Postdoctoral Researcher

    2 weken geleden


    Utrecht Oost, Nederland R&R Mechatronics International B.V. Voltijd

    “Exciting two-year postdoctoral opportunity at the intersection of science, business, and assay development. Focus areas include cell physiology and the development of a biomarker for assessing the severity and treatment efficacy in thalassemia.” **Research Field**: Red Blood Cells, Thalassemia, Oxidative Stress, Red Cell Physiology. **Background**: A...


  • Utrecht Oost, Nederland Prinses Máxima Centrum Voltijd

    We are looking for a highly motivated, ambitious, and passionate postdoctoral researcher with a strong affinity for both wet - and dry-lab technologies. Activities include cutting edge (single-cell) sequencing and spatial transcriptomics approaches, as well as organoid culturing, CRISPR gene editing, drug screens, and imaging technologies. **Background...


  • Utrecht Binnenstad, Nederland Universiteit Utrecht Voltijd

    Postdoctoral artistic research position in ERC project RESPIRE to study intersectional power dynamics and socio-environmental in/justice through planetary breathing and suffocation. **Your job**: The Postdoctoral position is for an artistic researcher whose artistic practice focuses on non-representationalist, performative, and norm-challenging approaches...


  • Utrecht Oost, Nederland Universiteit Utrecht Voltijd

    Are you an experienced pharmacoepidemiologist eager to advance your career in a dynamic and supportive environment? This position might be the perfect fit for you! Join us at Utrecht University, where cutting-edge research and inspiring teaching converge to make a meaningful impact on public health. **Your job**: - contribute and support ongoing research...


  • Utrecht Oost, Nederland Universiteit Utrecht Voltijd

    Utrecht University’s Strategic Theme Dynamics of Youth focuses on youth development from conception to early adulthood, connecting science with society to empower children, adolescents, and emerging adults. We are honoured to have appointed the Prince Claus Chair: The Science of Well-Being and Quality of Life Studies in Youth - A Social Justice...


  • Utrecht Oost, Nederland Universiteit Utrecht Voltijd

    Vulnerable neighbourhoods provide strategic spatial and institutional challenges for urban energy transitions, especially in developing collective agency and achieving just transitions. In our research project “Collective agency and co-evolution toward inclusive energy transitions” (CO2PED) we build concrete tools to strengthen the urban transformative...


  • Utrecht, Nederland UMC Utrecht Voltijd

    **Elke dag de zorg en de gezondheid van mensen verbeteren**Goede arbeidsvoorwaarden**Jezelf continu blijven ontwikkelen vinden we belangrijk** **Dit ga je doen** You will lead your own project to discover and characterize modifiers of disease pathways in iPSC models of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease that effects 1 in...


  • Utrecht, Nederland Koninklijke Nederlandse Akademie van Wetenschappen Voltijd

    **Location**:Utrecht **Max hours per week**:38.00 **Max salary**:3.771 **Duration of agreement**:13 months The group of Dr. Catherine Robin currently has a vacancy for **a technician full time** (38 hours/week) to work on the topic of hematopoietic stem cell generation and regulation. **Lab topics**: The Robin lab studies the cellular and molecular...


  • Utrecht Oost, Nederland Universiteit Utrecht Voltijd

    The Faculty of Social and Behavioural Sciences at Utrecht University has an opening for a postdoctoral research project. The vacancy is temporary, for a fixed period of 12 months and is funded the Dutch health services research funder (ZonMw). **Your job**: Vaccines are a very effective way to prevent the spread of infections. However, citizens may decide...


  • Utrecht, Nederland Universiteit Utrecht Voltijd

    The Ethics Institute of Utrecht University’s Department of Philosophy and Religious Studies seeks a researcher for a 3-year, full-time postdoctoral project “_Mutual Justification and Disruptive Technology_”, as part of the inter-university Gravitation consortium _Ethics of Socially Disruptive Technology (ESDiT)_. **Your job**: We are looking for a...


  • Utrecht, Nederland Prinses Máxima Centrum Voltijd

    We are looking for a motivated research technician with experience in antibody engineering to join the Janda group. The Janda group pursues various projects to leverage proteins and antibody engineering for innovative approaches to diagnose and treat childhood cancer. This includes the generation of antibodies and antibody fragments against newly identified...


  • Utrecht, Nederland UMC Utrecht Voltijd

    We seek an enthusiastic PhD student to improve childhood epilepsy diagnosis and prognosis through genetics. Collaborate with UMCU's Genetics and Neurology teams and contribute to cutting-edge clinical and scientific research.**Elke dag de zorg en de gezondheid van mensen verbeteren**Goede arbeidsvoorwaarden**Jezelf continu blijven ontwikkelen vinden we...


  • Utrecht, Nederland UMC Utrecht Voltijd

    We offer a position for a research technician to perform in-depth cellular research, aimed to understand how isolated respiratory syncytial virus (RSV) proteins can change airway epithelial cell function.**Elke dag de zorg en de gezondheid van mensen verbeteren**Goede arbeidsvoorwaarden**Jezelf continu blijven ontwikkelen vinden we belangrijk** **Dit ga je...


  • Utrecht Oost, Nederland Prinses Máxima Centrum Voltijd

    Improvements in outcome for children with cancer that both increase survival and reduce late effects of treatment may be realized by the introduction of novel (targeted) drugs or ATMPs with different modes of action than the existing therapy modalities, such as chemotherapy. In order to further strengthen our capacity for clinical innovation and to expand...


  • Utrecht Oost, Nederland Prinses Máxima Centrum Voltijd

    We are seeking a highly motivated, flexible, and innovative postdoctoral researcher with a strong background in antibody engineering and functional testing to join the Janda group at the Princess Máxima Center for pediatric oncology. **Your qualifications** - A PhD in protein engineering, immune-oncology, cancer biology, or a closely related discipline. -...

  • Associate Professor

    1 week geleden


    Utrecht, Nederland UMC Utrecht Voltijd

    Are you an expert in iPSC-based human disease models? Is your ambition to unravel disease processes and work towards effective treatments? Then you are the researcher we are looking for to strengthen our research community.**Elke dag de zorg en de gezondheid van mensen verbeteren**Goede arbeidsvoorwaarden**Jezelf continu blijven ontwikkelen vinden we...


  • Utrecht, Nederland Universiteit Utrecht Voltijd

    PFAS (per - and polyfluoroalkyl substances) are so-called ‘’forever chemicals’’ that are found everywhere: in our soils, water, food and bodies. PFAS contamination of soils is an increasingly important global issue, and we still lack sustainable methods for PFAS remediate. The PFAS Remediation Living Lab is a contaminated location at the Utrecht...