Postdoc Crispr Technologies in Neurogenomics

4 weken geleden


Utrecht, Nederland UMC Utrecht Voltijd

**Elke dag de zorg en de gezondheid van mensen verbeteren**Goede arbeidsvoorwaarden**Jezelf continu blijven ontwikkelen vinden we belangrijk**

**Dit ga je doen**

You will lead your own project to discover and characterize modifiers of disease pathways in iPSC models of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease that effects 1 in 350 people. Your work will leverage markers of ALS pathology that have already been established using a combination of human genetics analyses, omics / neuropathological profiling of postmortem patient tissue and iPSC studies.

In the second phase of your project, you will dissect the mechanistic links between prioritized modifiers and ALS phenotypes. Through this you aim to provide new insights into disease mechanisms and establish novel targets for ALS translational research. The tools available to you to perform this work include a range of established ALS iPSC lines, isogenic controls, iPSC neuron/organoid culture facilities, microfluidic systems, cellular imaging (calcium, confocal, lightsheet) as well as standard biochemistry and neurobiology techniques. A range of assays for specific ALS phenotypes have also already been established. Your work will also be supported by interactions with colleagues that have experience in ALS, iPSC models, bioinformatics, genomics and a diverse areas of neuroscience.

**Hier ga je werken**

The project will be performed within the department of Translational Neuroscience at the UMC Utrecht Brain Center. The department uses a wide range of cutting edge technologies, disease models and computational tools to study development and disease in neural systems. You will also work within the framework of the Dutch ALS centre (ALS centrum), a world leading multidisciplinary unit dedicated to advancing translational, preclinical and clinical research in ALS.

The project will be supervised by Prof Jeroen Pasterkamp and Dr Kevin Kenna. Your work will leverage state of the art facilities as well as multiple established collaborations within the UMC Utrecht.

**Dit neem je mee**
- You are an established postdoctoral researcher or recently graduated PhD in a relevant scientific discipline and demonstrable experience in molecular cloning and iPSC models.
- You are motivated to grow your career by taking ownership of a research project focused on molecular mechanisms in neurodegenerative disease.
- Prior experience in cell sorting, in situ hybridization assays, lentiviral transduction, CRISPR technologies or bioinformatics is valued but not required.
- You are interested to combine iPSC models of ALS with high throughput perturbation assays and subsequent functional studies.
- You are a team player, you enjoy collaboration across disciplines and you are a good communicator.

**Dit bieden we jou**
- A salary between € 3493 and € 5504 gross per month (scale 10), based on full-time employment (36 hours).
- An employment contract for 3 years. Upon a positive performance, the contract can be extended.
- Year-end bonus of 8.3% and holiday allowance of 8%.
- Pension insurance with ABP. We take care of approximately 70% of the monthly contribution.
- 100% public transport reimbursement. Are you coming on foot, by bike or by car? You will then receive a reimbursement of € 0.18 per km (by car up to a max. of 40 km one way).
- Possibilities to develop yourself personally and professionally.
- The option to select additional employment benefits in exchange for gross salary, such as purchasing a bicycle and memberships.

Wij geloven in de kracht van een divers team waarin ruimte is voor verschillende vaardigheden, expertises, sociale en culturele achtergronden. Wij zijn benieuwd naar jou
- Onze nieuwe collega's werven we zelf. We hebben geen behoefte aan acquisitie._

**Sollicitatieprocedure**
- ** Een leuke vacature gevonden?**- **
Dank voor je sollicitatie**
- Je ontvangt meteen een ontvangstbevestiging van ons.- **
Selectieproces**
- Binnen twee weken na sluiting vacature hoor je van ons of je bent uitgenodigd- **
Eerste gesprek**
- Samen kijken we of er een match is.- **
Tweede gesprek**
- Bij een match volgt er een voorstel arbeidsvoorwaarden of assessment.- **
Welkom**
- Wat fijn dat je bij ons aan de slag gaat Heel veel werkplezier**Kom meer te weten over werken bij het UMC Utrecht**

**Dit bieden we jou**

Kom je bij ons werken? Dan geldt voor jou de cao umc. Daarnaast bieden we je nog veel meer en organiseren we van alles zodat jij jezelf kan blijven ontwikkelen.

**Samen zijn wij UMC Utrecht**

Wij geloven in de kracht van een divers team waarin ruimte is voor verschillende vaardigheden, expertises, sociale en culturele achtergronden. Wij zijn benieuwd naar jou

**Kom je langs**

Binnen het UMC Utrecht organiseren we regelmatig evenementen. Zo kan jij je goed oriënteren op werken bij ons ziekenhuis



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