Postdoc: Discovering Car T Cell Biophysics with

**Work Activities**: Notably, a complex spatio-temporal dynamics is thought to be central to CAR T cell activation, but is difficult to measure and hence remains poorly understood. That the activation relies on the movement and association of many receptors and accesory proteins in an orchestrated manner is a fascinating notion. By addressing this question...

**Work Activities**: **Summary -** In this project, you will use advanced 3D imaging and AI-driven cell tracking to reveal the remarkable self-organization of cells within intestinal organoids. Using a biophysics approach, you will study how stem cells move, grow, divide, and differentiate into specific functional cell types, and hence reveal how functional...

**PhD in biophysics: Single-cell Tracking in Organoids**: **Work Activities**: **Summary -** In this project, you will use advanced 3D imaging and AI-driven cell tracking to reveal the remarkable self-organization of cells within intestinal organoids. Using a biophysics approach, you will study how stem cells move, grow, divide, and differentiate into...

**Work Activities**: **Summary -** In this project, you will use advanced 3D imaging and AI-driven cell tracking to reveal the remarkable self-organization of cells within intestinal organoids. Using a biophysics approach, you will study how stem cells move, grow, divide, and differentiate into specific functional cell types, and hence reveal how functional...

**Postdoc: Single-molecule microscopy of checkpoint therapeutic action on T cells**: **Work Activities**: As postdoc member of the REPRESSIT consortium coordinated the Physics of Cellular Interactions group headed by Dr. Kristina Ganzinger, you will work on developing a new type of cancer therapeutic (checkpoint inhibitor) in a biophysical project right at...

About SanquinSanquin is a knowledge-driven, not-for-profit organization providing life-saving products and services while conducting cutting-edge research in blood transfusion medicine and immunology.Our MissionWe ensure a better life for patients by working together with donors. Our research focuses on five medical needs: Anemia, Bleeding and Hemostasis,...

Stem cells are valuable tools for modelling human and animal diseases, as well as a source of differentiated cells for use in regenerative medicine and drug discovery. An essential prerequisite for using stem cells in medicine is the assurance of genetic stability. We are looking for a postdoc to be involved in research on the pathogenesis of stem cell...

**PhD in Biophysics: Chaperone-guided formation of single protein complexes**: **Work Activities**: Do you want to discover how multi-protein assemblies are produced without error? The aim of this project is to reveal this vital cellular process at the single-molecule level. Our research group has been at the vanguard of studying chaperone-protein...

Company Overview\The Netherlands Cancer Institute, a leading research center in the field of cancer immunotherapy, is seeking an experienced T cell immunotherapy analyst to join our BioTherapeutics Unit. Our team focuses on the development of innovative cellular therapies for the treatment of various forms of cancer.Salary and Benefits\We offer a competitive...

**Postdoc: Chaperone-guided formation of single protein complexes**: **Work Activities**: Do you want to discover how multi-protein assemblies are produced without error? The aim of this project is to reveal this vital cellular process at the single-molecule level. Our research group has been at the vanguard of studying chaperone-protein interactions using...

We are seeking a highly motivated, self-driven postdoctoral researcher in bioinformatics to the Kool group at the Princess Máxima Center for pediatric oncology. Our group studies the genomics and epigenomics of pediatric brain tumors and how to translate findings from these studies into novel therapies. Do you want to contribute to the Princess Máxima...

Are you passionate about stem cell research? Sanquin Research offers an exciting internship opportunity where you'll work with iPSCs, focusing on their maintenance and differentiation into blood cells. This project aims to develop clinically relevant cellular products. Curious? Read on! About Sanquin Sanquin’s mission is: “Together with the donor,...

**Work Activities**: Do you want to discover how multi-protein assemblies are produced without error? The aim of this project is to reveal this vital cellular process at the single-molecule level. Our research group has been at the vanguard of studying chaperone-protein interactions using optical tweezers, which allows one to follow the movements and folding...

**About the project**: Our group aims to attain broader relevance of CAR-T cell therapy through improvement of tumor targeting and tumor elimination, overcoming resistance, minimization of off-tumor toxicity and expansion of the availability across histocompatibility barriers. We use iPSCs as an unlimited source of off-the-shelf CAR-T cells and have...

**PhD student: Single-molecule biophysics of the ubiquitin motor Cdc48/p97**: **Work Activities**: **Questions -** Ubiquitin is central to a broadly important regulatory system within cells, which controls anything from protein degradation to membrane remodeling and DNA replication regulation. Cdc48 performs these tasks by disassembling protein complexes,...

**Postdoc: Nanophotonics and quantum physics with electrons and light**: **Work Activities**: Did you know high-energy electrons can serve as efficient sources of optical excitation of matter? Our group has developed cathodoluminescence microscopy, in which we use 1-30 keV electrons in a scanning electron microscope (SEM) to excite nanomaterials. The...

**The single-molecule dynamics and biophysics of the ubiquitin motor Cdc48/p97**: **Work Activities**: **Questions -** Ubiquitin is central to a broadly important regulatory system within cells, which controls anything from protein degradation to membrane remodeling and DNA replication regulation. Cdc48 performs these tasks by disassembling protein...

Cells are crowded with biomolecules, which could affect protein behavior through macromolecular crowding. Crowding depends on stress and cell type and, therefore, its consequences will vary. This makes it pertinent to determine intracellular crowding in different (disease) states and identify its potentially toxic consequences. **Your job**: **Your...

We are seeking a highly motivated and talented Postdoctoral Researcher to join our team and contribute to our ongoing projects in computational genomics. **The Position** We are seeking a highly motivated computational biologist with a PhD in genomics, cancer biology, or related fields, ideally with experience in single-cell genomics and machine learning....

**About the project**: This collaborative project is embedded in the Amsterdam Institute for Infection and Immunity and is funded by the ADORE Foundation. **ADORE**, which stands for **A**mster**D**am **O**ncology and Neuroscience **RE**search, is a collaborative effort between the Cancer Center Amsterdam and Amsterdam Neuroscience, comprising a total of...