Laboratory Master’s Internship: Targeted Therapy

2 weken geleden


Utrecht Oost, Nederland Prinses Máxima Centrum Voltijd

Cure every child with cancer, with optimal quality of life. That is the mission of the Princess Máxima Center. The Princess Máxima Center is located in Utrecht as a national center for all children and adolescents with cancer. Every year, about 600 children in the Netherlands get cancer and about 150 children have a recurrence after previous treatment. The Princess Máxima Center is a comprehensive cancer center, focused on providing pediatric oncology care, conducting pediatric oncology research and training professionals. Intensive collaboration is necessary to achieve a leading, international center of excellence. Pioneering, welcoming and passionate are the key words that define the culture and image of the Princess Máxima Center. We go further than others have ever gone, and we do so with heart and souI.

**Molenaar Group**

**Research project**
In our group, we have identified common chromosomal rearrangements and genomic aberrations that drive neuroblastoma, making them promising drug targets. These targets include components of the cell cycle machinery. Testing of small molecule inhibitors against these targets in various neuroblastoma models did however not yield the expected results. Therefore, we have initiated collaborations with external groups to evaluate the efficacy of novel therapeutics such as degraders and macrocycles. This internship project will involve in vitro testing of these preclinical drugs in various neuroblastoma models, including cell lines and organoids. Mode-of-action studies will be conducted using various experimental techniques such as Western blot, flow cytometry, and immunofluorescent imaging, with the ultimate goal of determining the suitability of these drugs for further development.

**Education and skills**

**What we offer**
A challenging internship position lasting a minimum of six months in an inspiring and highly multidisciplinary environment, supervised by a PhD student and a post-doc. The work is expected to be performed on-site as you will be running a lot of experiments in the lab.

**Contact**

**Application**

The closing date for this vacancy is December 22, 2024
- Acquisitie naar aanleiding van deze vacature wordt niet op prijs gesteld._

**Contactpersoon**:
Dylan Jongerius



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