Phd Understanding and Repairing Astrocyte

2 maanden geleden

AmsterdamZuidoost, Nederland Amsterdam UMC Voltijd

**About the project**:
Research in the **Amsterdam Leukodystrophy Center** aims at improving insight into leukodystrophies and developing treatment. The disease **“Megalencephalic Leukoencephalopathy with subcortical Cysts”** (MLC) has been a major research focus since long. In MLC, the homeostasis of ions and water in the brain is disrupted due to a dysfunction of supportive brain cells called astrocytes. As a consequence, the brain white matter is chronically swollen starting in early childhood. Electrical activity in the brain is disturbed, and patients suffer from motor dysfunction, cognitive disability and epilepsy. There is no curative treatment for the disease.

This project aims to investigate the potential for therapeutic intervention by targeting MLC related proteins to recover astrocyte function. The PhD student will characterize novel mouse models for MLC by studying behavioral, molecular and neuropathological aspects of these models, and compare them to existing animal models. In addition, cellular studies will be performed aimed at understanding disrupted intracellular signaling that underlies astrocyte dysfunction in these models. Finally, we aim to test how small molecules can target this disrupted signaling with the ultimate goal to recover MLC phenotypes in cells and mice.

The project is a tight collaboration between the team of Dr. Rogier Min (**Amsterdam Leukodystrophy Center**) and the **Department of Medicinal Chemistry **(Prof. Rob Leurs; Vrije Universiteit Amsterdam), where high-throughput signaling assays will be performed to identify potential therapeutic compounds for MLC treatment.

**About the role**:
**What will you do**:

- Familiarize yourself with astrocyte physiology in the context of MLC, and with underlying disease mechanisms;
- Familiarize yourself with existing and novel transgenic animal models for MLC;
- Characterize new models using phenotypic scoring, immunostainings and molecular tests;
- Study disease mechanisms in primary astrocyte cell culture and other cell models for MLC;
- Test whether potential therapeutic compounds identified in this project can improve MLC phenotypes in cells and animal models.

**Profile**:
**What do you bring**:
We are looking for an enthusiastic PhD student, who:

- Holds a Master degree in Neurosciences, Biomedical Sciences;
- Has proven interest in the field of (cellular) neuroscience, with affinity for neurological diseases or astrocyte physiology;
- Holds an Article 9 qualification for animal experimentation;
- Is fluent in English;
- Is highly motivated;
- Can work independently and in a team;
- Has excellent communication skills;
**Our offer**:

- A flying start to your career in scientific research;
- Plenty of room for your drive to shape tomorrow's healthcare;
- Working on large-scale and in-house research, with motivated colleagues from all over the world;
- You will be employed by Amsterdam UMC Research BV;
- A contract for 12 months (with the intention to extend);
- Salary scale OIO: € 3.017 in the first year and increasing to € 3.824 gross based on full-time employment in the fourth year and a year-end bonus of 8.3%. Calculate your net salary here;
- Holiday hours: 186,4 per year for fulltime and a possibility to save additional hours;
- Pension accrual with BeFrank, a modern, comprehensible and fairly priced pension;
- For >7 km each way, 100% reimbursement for public transport travel costs and, for private transport, €0.18 per km up to a maximum of 40 km each way;
- Do you prefer walking or cycling? Take advantage of our good bike scheme. Moreover, you will receive a reimbursement of €0.18 per km.

Watch this video with more information about joining Amsterdam UMC Research BV.

**About the workplace**:
We offer an excellent research environment. The **Amsterdam Leukodystrophy Center **consists of a multidisciplinary team of clinicians and laboratory researchers focusing on many different aspects of leukodystrophies. The team contains child neurologists, 6 research PI’s, trial coordinators, a post-doc, research technicians, PhD students and numerous interns. Some of us work on clinical aspects of leukodystrophies using patient registries or on clinical trials in patients. Others work in the lab and execute studies on disease mechanisms, with the aim to better understand these diseases and find openings for treatment. Working in this multidisciplinary team means that you will gain insight into many different aspects of leukodystrophies and preclinical studies.

The project is carried out in collaboration with the department of Medicinal Chemistry (Vrije Universiteit Amsterdam), where researchers study cellular signaling and work on drug design to modulate such signaling using innovative cellular assays. A PhD student in this department will closely collaborate with the PhD student that we are recruiting.

Amsterdam UMC Research BV supports non-profit scientific research. In doing so, we provide researchers wi

  • Phd Student Understanding and Improving

    1 maand geleden

    Amsterdam, Nederland Universiteit van Amsterdam Voltijd

    PhD Student Understanding and Improving Adolescents' Climate Friendly Choice **Faculty/Services**:Faculty of Social and Behavioural Sciences**Educational level**:Master**Function type**:PhD position**Closing date**:10 January 2025**Vacancy number**:13637- - Join the project “How do intentions and outcomes shape adolescents’ climate friendly choices: a...

  • Phd Epidemiology of Dialysis and Kidney

    3 maanden geleden

    Amsterdam-Zuidoost, Nederland Amsterdam UMC Voltijd

    **About the project**: **About the role**: As a PhD student, you will conduct research in the field of epidemiology of patients with kidney disease who are treated with dialysis or a kidney transplant. Your research will focus on international differences in the occurrence and outcomes of these patients. We are currently expanding the ERA Registry database...

  • Phd Mixotrophic Microalgae in Antarctic Carbon and

    1 maand geleden

    Amsterdam, Nederland Universiteit van Amsterdam Voltijd

    PhD Mixotrophic Microalgae in Antarctic Carbon and Sulfur Cycles **Faculty/Services**:Faculty of Science**Educational level**:Master**Function type**:PhD position**Closing date**:5 January 2025**Vacancy number**:13619- **Come work at the largest university of the Netherlands!** - The Antarctic seasonal sea-ice zone is rapidly changing, with consequences for...

  • Phd Coastal Squeezing Dynamics and Solutions

    1 maand geleden

    Amsterdam, Nederland Universiteit van Amsterdam Voltijd

    PhD Coastal Squeezing Dynamics and Solutions **Faculty/Services**:Faculty of Science**Educational level**:Master**Function type**:PhD position**Closing date**:6 January 2025**Vacancy number**:13582- Do you want to work in an interdisciplinary team to help understand the complex natural and social dynamics involved in coastal squeezing in order to generate...

  • Phd On Denguevirus Infection in Human

    2 maanden geleden

    Amsterdam-Zuidoost, Nederland Amsterdam UMC Voltijd

    **About the project**: There is a poor understanding of the pathogenesis of disease in humans for many viruses such as dengue virus due to a lack of adequate human models. Therefore, this specific project within the OrganoVIR Labs at Amsterdam UMC will employ advanced human blood-brain barrier and brain organoids to study neuropathogenesis of dengue virus....

  • Phd Positions in Astronomy and Astrophysics

    4 maanden geleden

    Amsterdam, Nederland Universiteit van Amsterdam Voltijd

    PhD Positions in Astronomy and Astrophysics **Faculteit/Dienst**:Faculteit der Natuurw., Wiskunde & Informatica**Opleidingsniveau**:Master**Functie type**:Promotieplaats**Sluitingsdatum**:4 November 2024**Vacaturenummer**:13399- **What are you going to do?** - You execute a vigorous research program, under the supervision of one or more faculty members....

  • Phd Student to Study Genome Stability Maintenance

    7 maanden geleden

    Amsterdam, Nederland Netherlands Cancer Institute Voltijd

    **Function description**: - The research group of Jacqueline Jacobs at the division of Oncogenomics aims to understand the processes that act to safeguard genome integrity but that, when working inappropriately, cause cells to become dysfunctional or die, or to get derailed and cancerous. More specifically, we aim to identify new factors and molecular...

  • Phd: Interorganizational Learning and Knowledge

    4 maanden geleden

    Amsterdam Zuid, Nederland Vrije Universiteit Amsterdam Voltijd

    **Your function**: **Project description** The Dutch industry needs a skilled workforce to keep up with and contribute to digital and green transitions. However, finding qualified employees is challenging, and skills quickly become outdated due to fast-developing technologies (AI, VR, robots). Currently, most Smart Industry companies lack human capital and...

  • Body Repair Operations Program Manager

    7 maanden geleden

    Amsterdam, Nederland Lucid Motors Voltijd

    **Leading the future in luxury electric and mobility** At Lucid, we set out to introduce the most captivating, luxury electric vehicles that elevate the human experience and transcend the perceived limitations of space, performance, and intelligence. Vehicles that are intuitive, liberating, and designed for the future of mobility. We plan to lead in this...

  • Phd Student to Study Quality of Life and Cancer

    5 maanden geleden

    Amsterdam, Nederland Netherlands Cancer Institute Voltijd

    **Function description**: - The research group of Lonneke van de Poll aims to understand the long-term and late effects of cancer treatment on symptoms, quality of life and socio-economic impact. Funded and in collaboration with the EORTC Quality of Life Group, we have developed a Survivorship Questionnaire (QLQ-SURV100). It measures the HRQOL of cancer...

  • Phd Position in Ai and Meaning-making

    3 maanden geleden

    Amsterdam, Nederland Universiteit van Amsterdam Voltijd

    PhD Position in AI and Meaning-Making **Faculteit/Dienst**:Faculteit der Geesteswetenschappen**Opleidingsniveau**:Master**Functie type**:Promotieplaats**Sluitingsdatum**:20 november 2024**Vacaturenummer**:13503- **What are you going to do?** - The recent breakthroughs in Large Language Models (LLMs) have reinvigorated the debate around the status of...

  • Phd Candidate Chemistry for Conservation and Art

    1 maand geleden

    Amsterdam, Nederland Universiteit van Amsterdam Voltijd

    **Faculty/Services**:Faculty of Science**Educational level**:Master**Function type**:PhD position**Closing date**:1-1-2025**Vacancy number**:13595- Are you a creative chemistry researcher who enjoys working in a very interdisciplinary environment to support the conservation of oil paintings? The Chemistry for Conservation and Art team at the Van ‘t Hoff...

  • Phd Position Vascular Immunometabolism

    2 maanden geleden

    Amsterdam-Zuidoost, Nederland Amsterdam UMC Voltijd

    **About the project**: In this PhD project, you will delve into the intricate relationship between endothelial cell metabolism and immunomodulation in the context of atherosclerosis. Your research will focus on understanding how alterations in endothelial cell metabolism are linked to their inflammatory phenotype and how these cells act as active...

  • Phd Position in Experimental Physics

    4 maanden geleden

    Amsterdam, Nederland Universiteit van Amsterdam Voltijd

    PhD Position in Experimental Physics **Faculteit/Dienst**:Faculteit der Natuurw., Wiskunde & Informatica**Opleidingsniveau**:Master**Functie type**:Promotieplaats**Sluitingsdatum**:31 October 2024**Vacaturenummer**:13384 - Do you enjoy working in an interdisciplinary research setting and are you interested in the intersection between nanophotonics and heat...

  • Phd Position in Electrocatalysis

    1 maand geleden

    Amsterdam, Nederland Universiteit van Amsterdam Voltijd

    PhD Position in Electrocatalysis **Faculty/Services**:Faculty of Science**Educational level**:Master**Function type**:PhD position**Closing date**:03.01.2025**Vacancy number**:13622- Join the Electrochemistry team, part of the Heterogeneous Catalysis and Sustainable Chemistry Group, in tackling one of the most pressing challenges in sustainable energy. This...

  • Phd Positions, Project 'spatiotemporal

    4 maanden geleden

    Amsterdam, Nederland Universiteit van Amsterdam Voltijd

    PhD Positions, Project 'Spatiotemporal Reconstruction of Interacting People for Perceiving Systems' **Faculteit/Dienst**:Faculteit der Natuurw., Wiskunde & Informatica**Opleidingsniveau**:Master**Functie type**:Promotieplaats**Sluitingsdatum**:31 oktober 2024**Vacaturenummer**:13444 - The Computer Vision lab provides 3 fully-funded PhD positions as part of...

  • Three Phd Positions in Ai, Digital Culture and Deep

    3 maanden geleden

    Amsterdam, Nederland Universiteit van Amsterdam Voltijd

    Three PhD Positions in AI, Digital Culture and Deep Learning **Faculteit/Dienst**:Faculteit der Geesteswetenschappen**Opleidingsniveau**:Master**Functie type**:Promotieplaats**Sluitingsdatum**:27 October 2024**Vacaturenummer**:13504- Would you like to become part of a dynamic community that is at the forefront of critical interdisciplinary research in...

  • Phd Position in Mechanistic Interpretability

    1 maand geleden

    Amsterdam, Nederland Universiteit van Amsterdam Voltijd

    PhD Position in Mechanistic Interpretability **Faculty/Services**:Faculty of Science**Educational level**:Master**Function type**:PhD position**Closing date**:31 December 2024**Vacancy number**:13609- - Come work at the largest university of the Netherlands- As machine learning (ML) models continue to have influence on everyday life, it becomes increasingly...

  • Phd Position On Political Corruption and Media

    3 maanden geleden

    Amsterdam, Nederland Universiteit van Amsterdam Voltijd

    PhD Position on Political Corruption and Media **Faculteit/Dienst**:Faculteit der Maatschappij - & Gedragswetenschappen**Opleidingsniveau**:Master**Functie type**:Promotieplaats**Sluitingsdatum**:31 October 2024**Vacaturenummer**:13515- Are you exceptionally interested in science, and specifically in the field of Political Corruption and Media? Is it your...

  • Phd Student On The Subject of Collaborative Ai

    7 maanden geleden

    Amsterdam, Nederland CWI Voltijd

    Are you inspired by building human-centric, explainable, and collaborative AI? There is a vacancy for a 4-year PhD position in the Intelligent and Autonomous Systems research group at Centrum Wiskunde & Informatica (CWI) in Amsterdam. **Job description**: Are you passionate about human-AI teamwork? Unfortunately, users often do not understand current AI...