Phd Understanding and Repairing Astrocyte

2 weken geleden

AmsterdamZuidoost, Nederland Amsterdam UMC Voltijd

**About the project**:
Research in the **Amsterdam Leukodystrophy Center** aims at improving insight into leukodystrophies and developing treatment. The disease **“Megalencephalic Leukoencephalopathy with subcortical Cysts”** (MLC) has been a major research focus since long. In MLC, the homeostasis of ions and water in the brain is disrupted due to a dysfunction of supportive brain cells called astrocytes. As a consequence, the brain white matter is chronically swollen starting in early childhood. Electrical activity in the brain is disturbed, and patients suffer from motor dysfunction, cognitive disability and epilepsy. There is no curative treatment for the disease.

This project aims to investigate the potential for therapeutic intervention by targeting MLC related proteins to recover astrocyte function. The PhD student will characterize novel mouse models for MLC by studying behavioral, molecular and neuropathological aspects of these models, and compare them to existing animal models. In addition, cellular studies will be performed aimed at understanding disrupted intracellular signaling that underlies astrocyte dysfunction in these models. Finally, we aim to test how small molecules can target this disrupted signaling with the ultimate goal to recover MLC phenotypes in cells and mice.

The project is a tight collaboration between the team of Dr. Rogier Min (**Amsterdam Leukodystrophy Center**) and the **Department of Medicinal Chemistry **(Prof. Rob Leurs; Vrije Universiteit Amsterdam), where high-throughput signaling assays will be performed to identify potential therapeutic compounds for MLC treatment.

**About the role**:
**What will you do**:

- Familiarize yourself with astrocyte physiology in the context of MLC, and with underlying disease mechanisms;
- Familiarize yourself with existing and novel transgenic animal models for MLC;
- Characterize new models using phenotypic scoring, immunostainings and molecular tests;
- Study disease mechanisms in primary astrocyte cell culture and other cell models for MLC;
- Test whether potential therapeutic compounds identified in this project can improve MLC phenotypes in cells and animal models.

**Profile**:
**What do you bring**:
We are looking for an enthusiastic PhD student, who:

- Holds a Master degree in Neurosciences, Biomedical Sciences;
- Has proven interest in the field of (cellular) neuroscience, with affinity for neurological diseases or astrocyte physiology;
- Holds an Article 9 qualification for animal experimentation;
- Is fluent in English;
- Is highly motivated;
- Can work independently and in a team;
- Has excellent communication skills;
**Our offer**:

- A flying start to your career in scientific research;
- Plenty of room for your drive to shape tomorrow's healthcare;
- Working on large-scale and in-house research, with motivated colleagues from all over the world;
- You will be employed by Amsterdam UMC Research BV;
- A contract for 12 months (with the intention to extend);
- Salary scale OIO: € 3.017 in the first year and increasing to € 3.824 gross based on full-time employment in the fourth year and a year-end bonus of 8.3%. Calculate your net salary here;
- Holiday hours: 186,4 per year for fulltime and a possibility to save additional hours;
- Pension accrual with BeFrank, a modern, comprehensible and fairly priced pension;
- For >7 km each way, 100% reimbursement for public transport travel costs and, for private transport, €0.18 per km up to a maximum of 40 km each way;
- Do you prefer walking or cycling? Take advantage of our good bike scheme. Moreover, you will receive a reimbursement of €0.18 per km.

Watch this video with more information about joining Amsterdam UMC Research BV.

**About the workplace**:
We offer an excellent research environment. The **Amsterdam Leukodystrophy Center **consists of a multidisciplinary team of clinicians and laboratory researchers focusing on many different aspects of leukodystrophies. The team contains child neurologists, 6 research PI’s, trial coordinators, a post-doc, research technicians, PhD students and numerous interns. Some of us work on clinical aspects of leukodystrophies using patient registries or on clinical trials in patients. Others work in the lab and execute studies on disease mechanisms, with the aim to better understand these diseases and find openings for treatment. Working in this multidisciplinary team means that you will gain insight into many different aspects of leukodystrophies and preclinical studies.

The project is carried out in collaboration with the department of Medicinal Chemistry (Vrije Universiteit Amsterdam), where researchers study cellular signaling and work on drug design to modulate such signaling using innovative cellular assays. A PhD student in this department will closely collaborate with the PhD student that we are recruiting.

Amsterdam UMC Research BV supports non-profit scientific research. In doing so, we provide researchers wi

  • Phd Student Understanding and Improving

    4 weken geleden

    Amsterdam, Nederland Universiteit van Amsterdam Voltijd

    PhD Student Understanding and Improving Adolescents' Climate Friendly Choice **Faculty/Services**:Faculty of Social and Behavioural Sciences**Educational level**:Master**Function type**:PhD position**Closing date**:10 January 2025**Vacancy number**:13637- - Join the project “How do intentions and outcomes shape adolescents’ climate friendly choices: a...

  • Repair Service Technician

    1 dag geleden

    Amsterdam, Noord-Holland, Nederland Undutchables Voltijd

    Job DescriptionSummary:In this role, you will be responsible for testing, troubleshooting, and repairing electronic/mechanical devices. You will perform rework and repair with strict adherence to internal policies and regulatory requirements.Main Responsibilities:Test, troubleshoot, and repair electronic/mechanical devices.Perform rework and repair with...

  • Phd Mixotrophic Microalgae in Antarctic Carbon and

    4 weken geleden

    Amsterdam, Nederland Universiteit van Amsterdam Voltijd

    PhD Mixotrophic Microalgae in Antarctic Carbon and Sulfur Cycles **Faculty/Services**:Faculty of Science**Educational level**:Master**Function type**:PhD position**Closing date**:5 January 2025**Vacancy number**:13619- **Come work at the largest university of the Netherlands!** - The Antarctic seasonal sea-ice zone is rapidly changing, with consequences for...

  • Phd Coastal Squeezing Dynamics and Solutions

    4 weken geleden

    Amsterdam, Nederland Universiteit van Amsterdam Voltijd

    PhD Coastal Squeezing Dynamics and Solutions **Faculty/Services**:Faculty of Science**Educational level**:Master**Function type**:PhD position**Closing date**:6 January 2025**Vacancy number**:13582- Do you want to work in an interdisciplinary team to help understand the complex natural and social dynamics involved in coastal squeezing in order to generate...

  • Phd Position in Children's Media and Diversity

    3 weken geleden

    Amsterdam, Nederland Universiteit van Amsterdam Voltijd

    PhD Position in Children's Media and Diversity **Faculteit/Dienst**:Faculteit der Geesteswetenschappen**Opleidingsniveau**:Master**Functie type**:Promotieplaats**Sluitingsdatum**:5 november 2024**Vacaturenummer**:13409- Are you looking for a challenging position in a dynamic setting? The Amsterdam School for Cultural Analysis (ASCA) currently has a vacant...

  • Repair Service Technician | English

    22 uur geleden

    Amsterdam, Nederland Undutchables Voltijd

    Test, troubleshoot, and repair electronic/mechanical devicesPerform rework and repair with strict adherence to internal policies and regulatory requirementsInstall and Test, troubleshoot, and repair electronic/mechanical devicesPerform rework and repair with strict adherence to internal policies and regulatory requirementsInstall and configure component...

  • Phd On Denguevirus Infection in Human

    4 weken geleden

    Amsterdam-Zuidoost, Nederland Amsterdam UMC Voltijd

    **About the project**: There is a poor understanding of the pathogenesis of disease in humans for many viruses such as dengue virus due to a lack of adequate human models. Therefore, this specific project within the OrganoVIR Labs at Amsterdam UMC will employ advanced human blood-brain barrier and brain organoids to study neuropathogenesis of dengue virus....

  • Phd Vascular Cell Biology

    3 weken geleden

    Amsterdam-Zuidoost, Nederland Amsterdam UMC Voltijd

    **About the project**: **The Integrity of the Vascular Endothelium** Blood vessel formation is essential for development and tissue health. Endothelial cells in the vessel wall are connected by molecular junctions that maintain vascular integrity. Recent discoveries show that mechanical tension at these junctions can generate protective signals, helping...

  • Phd Positions in Astronomy and Astrophysics

    2 weken geleden

    Amsterdam, Nederland Universiteit van Amsterdam Voltijd

    PhD Positions in Astronomy and Astrophysics **Faculteit/Dienst**:Faculteit der Natuurw., Wiskunde & Informatica**Opleidingsniveau**:Master**Functie type**:Promotieplaats**Sluitingsdatum**:4 November 2024**Vacaturenummer**:13399- **What are you going to do?** - You execute a vigorous research program, under the supervision of one or more faculty members....

  • Repair Service Technician | English

    3 weken geleden

    Amsterdam, Nederland Undutchables Voltijd

    Job description Test, troubleshoot, and repair electronic/mechanical devices Perform rework and repair with strict adherence to internal policies and regulatory requirements Install and configure component software Perform final functional testing to ensure product quality and reliability meet the highest standards Perform inventory transactions and...

  • Repair Service Technician | English

    2 weken geleden

    Amsterdam, Nederland Undutchables Voltijd

    Job description Test, troubleshoot, and repair electronic/mechanical devices Perform rework and repair with strict adherence to internal policies and regulatory requirements Install and configure component software Perform final functional testing to ensure product quality and reliability meet the highest standards Perform inventory transactions and...

  • Repair Service Technician | English

    1 week geleden

    Amsterdam, Nederland Undutchables Voltijd

    Job description Test, troubleshoot, and repair electronic/mechanical devices Perform rework and repair with strict adherence to internal policies and regulatory requirements Install and configure component software Perform final functional testing to ensure product quality and reliability meet the highest standards Perform inventory transactions and...

  • Doctorate Candidate Novel Repair Methods

    10 uur geleden

    Amsterdam, Noord-Holland, Nederland Amsterdam University of Applied Sciences (AUASHvA)) Voltijd

    In the maritime sector, there is a need for academic and more practice-based research to reinforce each other to make the sector safer and more sustainable. Technological solutions are offered from academia. However, without a deep understanding of the everyday practice of the sector, there might be doubt that the full potential of these developments can be...

  • Phd: Interorganizational Learning and Knowledge

    2 weken geleden

    Amsterdam Zuid, Nederland Vrije Universiteit Amsterdam Voltijd

    **Your function**: **Project description** The Dutch industry needs a skilled workforce to keep up with and contribute to digital and green transitions. However, finding qualified employees is challenging, and skills quickly become outdated due to fast-developing technologies (AI, VR, robots). Currently, most Smart Industry companies lack human capital and...

  • Phd Candidate Chemistry for Conservation and Art

    4 weken geleden

    Amsterdam, Nederland Universiteit van Amsterdam Voltijd

    **Faculty/Services**:Faculty of Science**Educational level**:Master**Function type**:PhD position**Closing date**:1-1-2025**Vacancy number**:13595- Are you a creative chemistry researcher who enjoys working in a very interdisciplinary environment to support the conservation of oil paintings? The Chemistry for Conservation and Art team at the Van ‘t Hoff...

  • Phd Position in Ai and Meaning-making

    4 weken geleden

    Amsterdam, Nederland Universiteit van Amsterdam Voltijd

    PhD Position in AI and Meaning-Making **Faculteit/Dienst**:Faculteit der Geesteswetenschappen**Opleidingsniveau**:Master**Functie type**:Promotieplaats**Sluitingsdatum**:20 november 2024**Vacaturenummer**:13503- **What are you going to do?** - The recent breakthroughs in Large Language Models (LLMs) have reinvigorated the debate around the status of...

  • Phd Student to Study Quality of Life and Cancer

    2 weken geleden

    Amsterdam, Nederland Netherlands Cancer Institute Voltijd

    **Function description**: - The research group of Lonneke van de Poll aims to understand the long-term and late effects of cancer treatment on symptoms, quality of life and socio-economic impact. Funded and in collaboration with the EORTC Quality of Life Group, we have developed a Survivorship Questionnaire (QLQ-SURV100). It measures the HRQOL of cancer...

  • Phd Student Genetics of Brain Activity in Health and Disease

    3 weken geleden

    Amsterdam-Zuidoost, Nederland Amsterdam UMC Voltijd

    **About the project**: Genetic factors influence how the brain processes and regulates behaviour, but the pathways linking genes to brain function remain poorly understood. This project explores the genetic basis of brain activity, focusing on electroencephalographic (EEG) brain oscillations, which reflect critical neural communication processes. By...

  • Phd Position Vascular Immunometabolism

    4 weken geleden

    Amsterdam-Zuidoost, Nederland Amsterdam UMC Voltijd

    **About the project**: In this PhD project, you will delve into the intricate relationship between endothelial cell metabolism and immunomodulation in the context of atherosclerosis. Your research will focus on understanding how alterations in endothelial cell metabolism are linked to their inflammatory phenotype and how these cells act as active...

  • Phd Position in Experimental Physics

    4 weken geleden

    Amsterdam, Nederland Universiteit van Amsterdam Voltijd

    PhD Position in Experimental Physics **Faculteit/Dienst**:Faculteit der Natuurw., Wiskunde & Informatica**Opleidingsniveau**:Master**Functie type**:Promotieplaats**Sluitingsdatum**:31 October 2024**Vacaturenummer**:13384 - Do you enjoy working in an interdisciplinary research setting and are you interested in the intersection between nanophotonics and heat...