Postdoc “treatment of Defects in Sugar

2 years **_We are looking for an enthusiastic and ambitious postdoctoral fellow to complete our team on sugar metabolism. Our research on patients with severe genetic metabolic diseases has revealed novel and unexpected evidence for tissue-specific biochemical mechanisms. We belief that uncovering such mechanisms will open new avenues for treatment of patients. In an ongoing prestigious Vici project, we will zoom in on the important sialic acid pathway to uncover these novel regulatory mechanisms in muscle and brain models. The overarching aim is to identify concrete treatment strategies via metabolic and genetic interventions._**

As postdoc, you will work together with three PhD students with complementary expertise on mass spectrometry and stem-cell models of muscle and brain. Depending on previous experience, you will contribute to a deeper understanding of the metabolic mechanisms with classical biochemical and genetic technologies, advanced cell culture, mass spectrometry, and/or bioinformatics. You collaborate with stem cell biologists and other mass spectrometrists to unravel the cell-type specific biology in sugar metabolism. Also, you design novel treatment approaches in stem cell models. At Radboud university medical center, you build on your future. We are committed to providing the best care, education, and research. And we are true to our word, because we help you develop and seize opportunities and give you the room to grow. As an employer, we believe that employees should feel vital and happy at work in all stages of life. We are also committed to creating a healthy and safe working environment. Our employment conditions contribute to that. What we offer:

- A gross monthly salary between € 3.493 and €5.504 (scale 10) for full-time employment (36 hours per week). You will also receive an 8% holiday allowance, an 8.3% end-of-year bonus, and, depending on the position, an allowance of 47% to 72% for working irregular hours.
- 172 vacation hours per year based on a 36-hour working week. (As of 1 January 2025, you will receive 176 vacation hours.)
- An Employment Conditions Selection Model, allowing you to use part of your employment conditions to your choosing. For example, you can use your gross salary to purchase additional vacation hours or hours for providing informal caregiving. Or, for example, you can use your gross end-of-year bonus to purchase a bicycle, so you pay less tax.
- Plenty of opportunities for personal development. You can take a variety of courses in our online learning environment.
- Your well-being and vitality are a priority. For example:

- Save time for work-life balance leave.
- A 40% discount on a sports membership of the Radboud Sports Center.
- Healthy Professionals program to help you manage your energy.
- Company Support Team and a personal coach if you are going through a life-changing event.
- Financially beneficial working less through a Generation Scheme as you approach state pension age.
- Support in achieving a good work-life balance at every stage of your life. Examples:

- Advice and courses on, for example, 'Millennial dilemmas' and 'Your Career After 57'.
- Activities at our own mindfulness center.
- Informal caregiving consultations if you have questions about juggling work and caregiving responsibilities at home.
- In addition to statutory pregnancy and maternity leave, Radboud university medical center offers 26 weeks of parental leave, nine of which are paid. In addition, as a partner you can take a maximum of five weeks of supplementary partner leave. During supplementary partner leave and parental leave, we supplement the UWV benefit up to 100% of your salary.
- Pension accrual at the ABP Pension Fund. Radboud university medical center pays 70% of the pension premium.
- Discounts on supplementary packages of two group health insurances and ten other types of insurance, from home insurance to legal assistance.
- As of 1 October 2024: an allowance for your commuting costs of € 0.18 per km up to a maximum of 40 km one way. If you use public transport to commute, we will fully reimburse the public transport costs (2nd class). If you regularly work from home, you will receive a working from home allowance of € 2.35 per day.

The project is embedded in the Radboudumc at the interface of the departments of Neurology, Genetics, and the Translational Metabolic Laboratory. Research in these departments is focused on Neurogenetic diseases, aiming for improved diagnosis, better understanding of underlying pathophysiology and development of novel therapeutic strategies.

The current position is in the Lefeber group “Glycosylation Disorders in Neurology” and will physically be located in the Translational Metabolic Laboratory and Human Genetics. The combined infrastructure is highly innovative including the Radboudumc Technology Center for mass spectrometry (proteomics, glycomics and (sugar)metabolomics) with a wide range of analytical equipment and