Phd Candidate 'personalized Treatment for Optimized

Multiple Myeloma (MM) is the 2nd most common haematological malignancy and is characterized by monoclonal expansion of plasma cells in the bone marrow. These plasma cells produce monoclonal immunoglobulins (M-proteins) that provide a unique cancer-biomarker. M-protein diagnostics is crucial for diagnosis, risk-stratification and follow-up of MM patients....

4 years **_Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with the lowest 5-year survival among all solid tumors. Cancer-associated fibroblasts (CAFs) promote tumor cell proliferation and prevent chemotherapy and immune cells from attacking the tumor, leading to poor patient outcome. Novel approaches to kill these CAFs are therefore...

The Department of Ophthalmology of the Radboud University Medical Center is a global leader in the field of multifactorial and genetic retinal eye diseases. The research of the department is focused on retinal forms of blindness that affect large numbers of patients worldwide, especially inherited retinal degenerations (IRDs), such as retinitis pigmentosa,...

The Department of Ophthalmology of the Radboud University Medical Center is a global leader in the field of multifactorial and genetic retinal eye diseases. The research of the department is focused on retinal forms of blindness that affect large numbers of patients worldwide, especially inherited retinal degenerations (IRDs), such as retinitis pigmentosa,...

This current PhD position compromises a clinical scientific collaboration between Radboudumc and the not-for-profit scientific organization of Synapse Research Institute. Synapse Research Institute has developed a novel hemostasis assay which can measure the breakdown of a blood clot, the plasmin generation assay. This assays will be performed in all patient...

Blindness is among the top 15 most disabling conditions, and can manifest in many different ways. In young people, a hereditary retinal condition is the main cause, while age-related macular degeneration is the main cause in the elderly. The Lifelong VISION program is developing a new generation of treatment strategies to prevent blindness: genetic...

4 years **_We are looking for a talented PhD student who will join our research group ’_**_Strenghts, positive aspects and resilience in neurodevelopmental conditions_**_’ at the department of psychiatry. Within this research group we focus on investigating positive aspects and resilience in for example people with ADHD. We hope to provide a more...

4 years **_About 1 in every 800 newborns is born with an inherited metabolic disease (IMD). These diseases are a major cause of death in children worldwide and are caused by genetic defects in over 1,500 known metabolic enzymes. Unfortunately, despite progress in early screening, biomarker discovery, diagnosis, and treatment, most IMDs (85%) are still not...

AMD primarily affects the central retina (macula), resulting in the progressive loss of central vision, significantly impacting the quality of life of millions of people, particularly the elderly. Despite advancements, the underlying mechanisms of AMD remain incompletely understood, and there is an urgent need for more effective treatments. This research...

4 years **_Cancer continues to be a major public health and economic burden, with 19.3 million new cases and 10 million deaths worldwide in 2020. As the global population ages, the incidence and mortality from cancer are expected to rise by 47% to 28.4 million new cases by 2040. Medical imaging, including CT and MRI scans, is critical in the management of...

4 years **_Are you interested in unraveling the immunopathogenesis of endometriosis and whether lifestyle interventions can manage pain in endometriosis? Come join us as for this exciting PhD project._** Endometriosis is a hormone-dependent chronic inflammatory disease, affecting 6-10 % of women in reproductive age and as such it is one of the major causes...

The project is a continuation of an ongoing collaboration on Bayesian Federated Inference and Survival Analysis between the two sections. In research into rare diseases only small data sets are typically available. When using such small data sets for prediction, the risk of overfitting in the models used is high. This limits severely the ability to infer...

2 years **_We are looking for an enthusiastic and ambitious postdoctoral fellow to complete our team on sugar metabolism. Our research on patients with severe genetic metabolic diseases has revealed novel and unexpected evidence for tissue-specific biochemical mechanisms. We belief that uncovering such mechanisms will open new avenues for treatment of...

4 years **_We offer an exciting PhD position for a scientist with a strong background in clinical research methodology, preferably in the context of drug development and with a keen interest in the impact of novel methodology on drug development and regulatory science and decision making for rare diseases. Will you help us with further research?_** The...

3 years **_Have you ever wondered why some cancers respond well to certain therapies and others do not? Tumours that develop as a result of BRCA1/2 deficiency are deficient in homologous recombination (HRD) and present a high level of genomic instability. The presence of HRD and related-genomic instability may guide treatment decisions for certain types of...

In radionuclide therapy, a tumor-targeting vector is coupled to a therapeutic radionuclide to specifically irradiate tumor lesions from inside the body. This approach allows for the delivery of a high radiation absorbed dose to (metastasized) tumor lesions, while sparing healthy tissues. Despite the high potential of treatment, we currently do not know which...

4 years **_Every day, clinics worldwide generate vast amounts of digital data on healthy and diseased individuals. Digital pathology alone, with its high-resolution imaging of tissue samples, provides wealth of large-scale data that can contribute to improved understanding of disease morphology and tissue phenotype, potentially providing new insights to help...

The project aims to examine uni You will furthermore be trained in soft skills like scientific presentation, participation in various (inter)national conferences, and will contribute to outreach activities. As an obligatory part of the PhD trajectory at the Radboudumc and the Donders Institute for Brain, Cognition and Behaviour, you are required to write...

Bladder cancer is in the top ten of most common cancers in the world; in the Netherlands, each year almost 7,000 people are diagnosed with bladder cancer. Our group aims to tackle unmet needs in the treatment of bladder cancer by use of epidemiological research. We are specialized in genetic epidemiological studies, but also study non-germline...

3 years Primary cilia are microtubule-based projections found on the surface of nearly every cell in our body. We know that humans critically depend on cilia to see, hear, smell, breathe, excrete and reproduce. Such activities require a high degree of regulation and critical feedback to ensure robustness in development and homeostasis of different cells,...