Phd Candidate 'personalized Treatment for Optimized
2 weken geleden
A total knee arthroplasty (TKA) is a successful intervention for treatment of advanced knee osteoarthritis. But it does not provide a permanent solution for every patient, so revision surgeries will be needed. With the increasing numbers of implants placed, also the numbers of revision implants will increase. When taking out the primary implant for revision total knee arthroplasty (rTKA), the surgeon has to deal with bone defects. These bone defects make it difficult to achieve proper fixation of the revision implants into the bone. Revision implants often require additional augmentation, such as stems, or a cone around the stem, to fill the bone defect and facilitate proper implant fixation.
Choosing the optimal surgical strategy is challenging because insufficient augmentation will lead to poor fixation, loosening and another surgery. And too much augmentation can lead to bone loss through stress shielding and this is costly.
We therefore need a personalized approach to ensure optimal fixation. The research project aims to provided substantiated evidence for surgical strategies to optimize implant fixation and subsequent survival of revision total knee replacements.
The project consists of four work packages. First, insight will be gained into the 3D geometry of rTKA bone defects based on CT-scans of patients. This information will be used in physical testing of cadaveric rTKA reconstructions, adopting various augmentation strategies. Physical testing will be simulated in computational models based on finite element analysis. The validated methodology will then be used to generate a large population of models to determine the personalized optimal augmentation strategies.
Finally, the loop to the clinic will be closed in a clinical study implementing the personalized augmentation advice. Stability of the rTKA will be monitored with radiostereometric analysis and dynamic micromotion, known substitutes for long-term implant survival, eventually demonstrating the clinical validity of the personalized rTKA optimization advice.
**Tasks and responsibilities**
- Develop and perform scientific research in the field of orthopaedics, image processing, biomechanics, and clinical research.
- Generate and analyze data, write scientific publications, and present findings at scientific meetings.
- Participate in educational responsibilities of the department.
- Work in a multi-disciplinary team with fellow (PhD) students, scientists, and orthopedic surgeons to discuss, plans and perform research in a stimulating environment at the Orthopedic Research Lab of the Radboudumc and at the Sint Maartenskliniek.
- Complete the project with a scientific dissertation.
At Radboud university medical center, you build on your future. We are committed to providing the best care, education, and research. And we are true to our word, because we help you develop and seize opportunities and give you the room to grow. As an employer, we believe that employees should feel vital and happy at work in all stages of life. We are also committed to creating a healthy and safe working environment. Our employment conditions contribute to that. What we offer:
- Upon commencement of employment, you will start at scale 10A, step 0 (€ 3.017 based on a full-time appointment). Over a maximum period of 4 years, you will progress to scale 10A, step 3 (€3.824 based on a full-time appointment). You will also receive an 8% holiday allowance, an 8.3% end-of-year bonus, and a 47% to 72% bonus for working unsocial hours.
- 172 vacation hours per year based on a 36-hour working week. (As of 1 January 2025, you will receive 176 vacation hours.)
- An Employment Conditions Selection Model, allowing you to use part of your employment conditions to your choosing. For example, you can use your gross salary to purchase additional vacation hours or hours for providing informal caregiving. Or, for example, you can use your gross end-of-year bonus to purchase a bicycle, so you pay less tax.
- Plenty of opportunities for personal development. You can take a variety of courses in our online learning environment.
- Your well-being and vitality are a priority. For example:
- Save time for work-life balance leave.
- A 40% discount on a sports membership of the Radboud Sports Center.
- Healthy Professionals program to help you manage your energy.
- Company Support Team and a personal coach if you are going through a life-changing event.
- Financially beneficial working less through a Generation Scheme as you approach state pension age.
- Support in achieving a good work-life balance at every stage of your life. Examples:
- Advice and courses on, for example, 'Millennial dilemmas' and 'Your Career After 57'.
- Activities at our own mindfulness center.
- Informal caregiving consultations if you have questions about juggling work and caregiving responsibilities at home.
- In addition to statutory pregnancy and maternity leave, Radboud university medical center offers 2
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