Postdoc 'real-time Glycopeptide Identification
2 maanden geleden
3 years **_We are looking for a postdoc in informatics/chemometrics to develop analytical solutions for interpretation of glycopeptide fragmentation mass spectra in glycoproteomics. This project is a continuation of our Translational Metabolic Laboratory (TML) - Bruker Daltonics (BDAL) collaboration to develop software for real-time glycoproteomics data processing to, ultimately, advance patient care by unlocking large-scale site-specific glycobiology information. Are you the highly motivated and enthusiastic postdoc to help us with this project? We would like to get to know you_**
You will develop tools based on graph theory for database-free glycan topology identification from MS/MS data. Technology will be developed based on and implemented in a recently introduced glycoproteomics software, “GlycoScape”, in the “Myriad” workflow for real-time de novo glycopeptide identification (doi: 10.3390/ijms24097869). In addition, real-time glycopeptide identification capabilities will be exploited to enable on-the-fly adjustment of data acquisition decisions and parameters to enhance glycoproteome coverage.
With the GlycoScape - Myriad project, TML and BDAL follow an open innovation approach: while the code of Myriad is and will stay public, GlycoScape is a proprietary integrated version of Myriad. This allows external developers from the open-source community to contribute to future versions of Myriad, while the integration and optimization for the real-time analysis for timsTOF instrumentations will stay proprietary.
**Tasks and responsibilities**
- Develop real-time glycan topology identification algorithm based on proof-of-concept data using graph theory.
- Develop functions to direct data acquisition decisions and parameters based on real-time glycopeptide identification results when measuring.
- Disseminate results via scientific publications and presentations at scientific meetings.
- Share results and align technical developments with TML and BDAL experts.
At Radboud university medical center, you build on your future. We are committed to providing the best care, education, and research. And we are true to our word, because we help you develop and seize opportunities and give you the room to grow. As an employer, we believe that employees should feel vital and happy at work in all stages of life. We are also committed to creating a healthy and safe working environment. Our employment conditions contribute to that. What we offer:
- A gross monthly salary between € 3.493 and € 5.504 (scale 10) for full-time employment (36 hours per week). You will also receive an 8% holiday allowance, an 8.3% end-of-year bonus, and, depending on the position, an allowance of 47% to 72% for working irregular hours.
- 172 vacation hours per year based on a 36-hour working week. (As of 1 January 2025, you will receive 176 vacation hours).
As a post-doc you will be working within the Joint Center of Excellence for Translational Omics established among Radboud University Medical Center (RUMC) and Bruker Daltonics (BDAL) and will be physically based in the Translational Metabolic Laboratory (TML) of the department of Human Genetics at the RUMC.
**Translational Metabolic Laboratory**
TML is an ambitious mixed function laboratory with a focus on translational research and diagnostics for patient care. We harbor a range of top scientists in the areas of inherited (metabolic) diseases, mitochondrial disease, glycosylation disorders and more. Translational functional Omics technologies are applied at TML to develop novel personalized diagnostics. TML houses a broad range of mass spectrometry equipment including the latest generation trapped ion mobility spectrometry - quadrupole time-of-flight tandem mass spectrometry instruments (timsTOF Pro) connected online to GPU-powered real-time data processing hardware (ProteoScape/GlycoScape) and cloud-based computing infrastructure (Digital Research Environment). We coordinate the Radboud Technology Center for Mass Spectrometry and several large national and European projects including the Netherlands X-omics Initiative. There is a visual impression of TML available.
**Bruker Daltonics**
- and materials
- science questions at spatial biology, cellular, subcellular and molecular levels.
**Radboudumc**
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