Associate Researcher Oligonucleotide Chemistry
6 dagen geleden
ProQR Therapeutics is a biotechnology company listed on NASDAQ with offices in Leiden, the Netherlands and Cambridge, Massachusetts, USA. ProQR is focused on the development of life changing RNA therapies to meet the unmet need of individuals and families with common and rare diseases. A team of 150+ enthusiastic ProQRians from all walks of life and more than 30 different nationalities is up to this challenge. We have the passion and commitment to make a difference in the lives of the communities we serve. Our proprietary Axiomer RNA editing technology platform enables the editing of specific single nucleotides in RNA using the cells own editing machinery. Axiomer RNA editing technology harnesses ADAR (Adenosine Deaminase Acting on RNA), which is machinery present in all human cells to repair G-to-A mutations, modulate protein, and enable protective mutation functions. Axiomer could potentially yield a new class of innovative medicines and treat currently untreatable diseases.
Our Chemistry, Manufacturing and Control (CMC) department is currently looking for an **Associate Researcher Oligonucleotide Chemistry (Full-time)**to join our team.
**The Role**
- Manufacturing of oligonucleotides by performing all stages of the process, such as synthesis, cleavage & deprotection, and purification.
- Perform proper documentation and accurate record keeping of experimental data
- Execution of analytical tests (HPLC, UV-Vis, and mass spectrometry)
- Support preparation of technical protocols and reports
- Support the preparation, or revision, of standard operating procedures (SOPs)
- Support general lab activities such as equipment maintenance and inventory management
**Location**: Leiden, NL (on-site)
**We expect our Associate Researcher to have**:
- An MLO or HLO degree in; Organic chemistry, analytical chemistry, biochemistry, biopharmaceutical sciences or related scientific discipline with up to 2 years of industry experience.
- Strong laboratory skills and high degree of attention to detail.
- Good understanding of, and hands-on experience with, analytical techniques such as HPLC, LCMS and UV-Vis spectroscopy.
- A Proficiency in spoken and written English.
- A responsible person with a proactive attitude who can work independently.
- Being flexible, analytical, and well-organized.
- A team player.
**We would like our Associate Researcher to have**:
- Knowledge of oligonucleotide (or peptide) manufacturing (synthesis, purification and/or analysis) is a plus.
- Should enjoy challenging situations and have the flexibility to work in a dynamic and fast-moving environment where there is freedom to act.
**ProQR as an employer**
As an employer, we are a true believer of the value of a workforce in which people from diverse backgrounds are encouraged to develop themselves, personally and professionally. We believe that happy and energized people, working well together in an environment in which they thrive, will do phenomenal and awesome things.
We offer an exciting and innovative working environment in a very committed organization, with the following benefits:
- 8% holiday allowance
- 30 vacation days
- An annual performance bonus
- Stock options
- A premium-free pension plan
- A commuting allowance
- A subsidized staff restaurant
- Unlimited (un)healthy snacks and drinks
- Employee events (boot camp, Rebel Café and other social events)
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