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In Vitro Testing and in Vivo Assessment of Remyelination-promoting Factors for Ms
4 weken geleden
**Background**:
Multiple sclerosis (MS) is a neuroinflammatory disease characterised by the degeneration of the protective myelin sheath, leading to the formation of lesions in the central nervous system. Regeneration of myelin, known as remyelination, represents an attractive target for novel therapies to promote clinical recovery in MS. There is significant heterogeneity with regard to remyelinating capacity in MS, where there are distinct differences between both donors and lesion types. Previously, we identified targets to be enriched in donors and lesions with higher remyelinating capability that could potentially promote remyelination. In this project, we aim to functionally assess the potential of these targets in vitro and in vivo assays.
**Aims**:
- Assess effect of treatment on mice brain tissue
**Techniques**:
- Cell culture with nanofibers
- Sectioning of mouse brain tissue
- Immunofluorescent staining of mouse brain tissue
- Immunocytochemistry of cells
- Microscopy and image analysis
- Presentation and writing skills
For this project, you will work closely with a Alida Chen, a PhD student in the lab, and have the opportunity to join a friendly and supportive research group, learn how to functionally test targets using in vitro and in vivo assays, and benefit from the groups expertise in MS pathology, and gain more experience and independence in the lab.
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Amsterdam, Nederland Nederlands Herseninstituut Voltijd**Background**: Multiple sclerosis (MS) is a debilitating neuroinflammatory disease characterised by the degeneration of the protective myelin sheath, leading to the formation of lesions in the central nervous system. Regeneration of myelin, known as remyelination, represents an attractive target for novel therapies to promote clinical recovery in MS. We aim...
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Testing Coach
3 weken geleden
Amsterdam, Nederland Levy Professionals VoltijdWe are seeking an experienced and motivated **Test Coach** to join our client in the banking sector. As a Test Coach, you will work closely with development teams to ensure high-quality software delivery and guide them in implementing best testing practices. You will coach teams on both technical and non-technical aspects, supporting the optimization of...
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Compliance Monitoring and Testing Officer
3 weken geleden
Amsterdam, Nederland Bitvavo Voltijd**What is the role about?**: The role will be an integral part of our Compliance team. Our team, currently consisting of three Compliance Officers and a Compliance Manager, is dedicated to maintaining the highest standards of regulatory compliance and ethical conduct across all aspects of our business operations. In this role, you will assist with the...
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PhD position in Early life stress and Alzheimer's Disease
4 dagen geleden
Amsterdam, Noord-Holland, Nederland University of Amsterdam (UvA) VoltijdAre you fascinated by the way early life factors can influence the brain and its structure and functioning in later life? Do you want to know whether early life stress can lead to Alzheimer's Disease and how? Do you enjoy working in a lab with preclinical models and at the same time enjoy working with human data? Then this position might be perfect for you ...
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Amsterdam, Nederland IEA Data Processing and Research Center VoltijdThe International Association for the Evaluation of Educational Achievement (IEA) is an independent, nonprofit research organization. We conduct international and national large-scale comparative studies of educational achievement and other aspects of education, with the aim to research, understand, and improve education worldwide. The IEA office in...
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Ms Dynamics Associate- Remote
4 weken geleden
Amsterdam, Nederland SKYTREE B.V Voltijd**WE ARE SKYTREE** Skytree enables a transition to a world with cleaner Air for everyone. We do this by developing and deploying smart technology that captures atmospheric carbon dioxide, enabling its use or storage to combat climate change and aid society and businesses around the world. Born out of the European Space Agency (ESA), we are a global team of...
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Automation Testing
3 weken geleden
Amsterdam Centrum, Nederland ISPROX VoltijdAt ISPROX, we are leveraging our resources to support our client’s team in the search for an **Automation Testing - ETL Focus with SSIS** to join their team in Amsterdam. Our client is a multinational information technology consulting company with offices in 50 countries, serving various industries **They would like to offer you**: - Be part of an...
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Project Leader
2 weken geleden
Amsterdam, Nederland Avantium Voltijd**Department**: - R&D Solutions **Office**: - Headquarters **Location**: Amsterdam **Project Leader - Refinery Catalyst Testing**: **Who are we?** Avantium is a pioneer in the emerging industry of renewable and sustainable chemistry. We seek to take part in the opportunities of the transition towards a circular economy to create value for our...
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Program Manager I, Ring Insights
4 weken geleden
Amsterdam, Nederland Ring of Security B.V. - H42 VoltijdExperience in program or project management Are you a passionate, self-starting Program Manager interested in facilitating Alpha, Beta, and Delta testing for products designed to reduce crime in neighborhoods? Ring is looking for a Program Manager that is customer obsessed, has a bias for action, and wants to learn and be curious. You will join the Ring...
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Quality Assurance
7 dagen geleden
Amsterdam, Nederland Whale TV VoltijdResponsibilities 1. Field Testing Execution: - Conduct field testing for TV LiveTV functionalities, including but not limited to: Live channel playback (resolution, fluency, audio-video synchronization, etc.) Time-shift and replay functionality Interactive features - Execute test cases, document test results, and submit defect reports, tracking the...
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Quality Assurance
4 dagen geleden
Amsterdam, Nederland Whale TV VoltijdResponsibilities1. Field Testing Execution:- Conduct field testing for TV LiveTV functionalities, including but not limited to: Live channel playback (resolution, fluency, audio-video synchronization, etc.) Time-shift and replay functionality Interactive features- Execute test cases, document test results, and submit defect reports, tracking the progress of...
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Quality Assurance
3 dagen geleden
Amsterdam, Nederland Whale TV VoltijdResponsibilities1. Field Testing Execution:- Conduct field testing for TV LiveTV functionalities, including but not limited to: Live channel playback (resolution, fluency, audio-video synchronization, etc.) Time-shift and replay functionality Interactive features- Execute test cases, document test results, and submit defect reports, tracking the progress of...
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Phd in Cutting-edge Leukemia Research
1 week geleden
Amsterdam Zuid, Nederland Amsterdam UMC Voltijd**About the project**: The largest challenge associated with leukemia treatment is persistence of residual therapy-resistant cancer cells, called mínimal residual disease (MRD), which underlies disease relapse and is responsible for the low survival rates of patients. Currently, knowledge on mechanisms of persistence of MRD and initiation of leukemia...
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Technology Assessment and Strategy Intern
3 weken geleden
Amsterdam, Nederland NLC Voltijd**WHO ARE WE?** NLC Health Ventures is dedicated to advancing health, making it accessible for everyone. By using entrepreneurship at scale, our unique NLC approach allows us to find inventions, and create and support ventures that have the potential to reach the patient. We identify promising innovations at early TRL stages, pair them with entrepreneurial...
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Performance Testing Engineer
3 dagen geleden
Amsterdam, Nederland ThreatFabric Voltijd € 60.000 - € 80.000Test Engineer at ThreatFabric B.Position: Full-time | 40 hours per week Location: Hybrid | Amsterdam, Netherlands Level: Senior Financial Services | Software Development | Technology, Information, and Internet Software Testing | Product Delivery Skills: Test Automation | Manual QA | Communication | Problem Solving | Continuous Improvement |...
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Senior Consultant
4 dagen geleden
Amsterdam, Noord-Holland, Nederland Hamlyn Williams VoltijdRole Overview:As a Principal Consultant at Hamlyn Williams, you will become part of a team of experts providing specialized consulting services in the financial sector.Key Objectives:To collaborate with clients on a variety of climate and ESG risk-focused projects.To advise clients on updating their governance structures, risk management, and internal...
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Collaborating Expert in Developing and Applying
4 weken geleden
Amsterdam Zuid, Nederland European Medicines Agency Voltijd**Organizational Unit**: Stakeholders & Communication Division Not applicable Public Engagement & Stakeholders Office **Place of work**: Flexible (occasionally on EMA premises and remote). **Proposed length**: 9-12 months(extendable if needed). **Remuneration**: Experts should be salaried by their employer or be a post-graduate student (financed by their...
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Sales and Operations Coordinator
1 dag geleden
Amsterdam, Noord-Holland, Nederland Undutchables Voltijd € 3.300 - € 3.500Role OverviewWe are looking for a highly organized and communicative International Trade Liaison to join our team at Undutchables. In this role, you will be responsible for coordinating sales efforts, managing orders, and providing excellent customer service.Your main responsibilities will include:Building and maintaining strong relationships with...
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Sales and Relationship Manager
2 dagen geleden
Amsterdam, Noord-Holland, Nederland Undutchables Voltijd € 3.300 - € 3.500Company OverviewOur client is a fast-growing international manufacturing company specializing in construction machinery.Job DescriptionThe Sales Manager will be responsible for building and maintaining sustainable relationships with dealers through open, transparent, and interactive communication. This includes managing the order cycle, ensuring timely and...
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Salesforce Testing Lead Role
5 dagen geleden
Amsterdam, Noord-Holland, Nederland Connect Vision International Voltijd € 60 - € 75About the RoleWe are seeking an experienced Salesforce Test Manager to join our team in Amsterdam. This onsite role offers a unique opportunity to work on exciting Salesforce projects and collaborate with a talented team of professionals.Key ResponsibilitiesManage and execute Salesforce testing processesDevelop and maintain test plans, strategies, and...