Phd Student
4 weken geleden
**Location**:Utrecht
**Max hours per week**:38.00
**Max salary: €**3.539
**Duration of agreement**:1 year (extension for 3 years after positive evaluation)
**Description of the project**
Hematopoietic stem cells (HSCs) are responsible for the production and replenishment of all blood cell types throughout life. How HSCs are formed and acquire their stem cell properties, i.e. self-renewal and multipotency, has inspired scientists and clinicians for many decades, leading to life-saving medical treatments, such as HSC transplantation. The adult HSC identity is already specified in the embryo, where concomitant with the initiation of the heartbeat, some
endothelial cells embedded in the wall of the aorta gain a hemogenic potential, allowing these cells to transdifferentiate to acquire an HSC fate. Despite intensive research efforts, basic questions on HSC emergence and regulation remain unanswered.
This project will explore the fundamental requirement to regulate HSC production by the transcription factor Gata2 both in vivo (in zebrafish models) and in vitro. Different cellular and molecular experimental approaches will be used, including cell culture, western blot, cloning, PCR, Crispr-cas9, live imaging in zebrafish embryos, FACS. The overall goal of this innovative project is to explore how different mutations reported in childhood patients (i) affect the function of GATA2 at the molecular level, (ii) predispose to MDS/AML (onset and progression of aberrant hematopoiesis) and (iii) impact the treatment response _in vivo_.
**Requirements**:
**About the Hubrecht Institute**
The Hubrecht Institute is a research institute focusing on developmental and stem cell biology. At the institute, more than 20 research groups perform fundamental and multidisciplinary research, both in healthy systems and disease models. The Hubrecht Institute is a research institute of the Royal Netherlands Academy of Arts and Sciences (KNAW) and is located on the Utrecht Science Park ‘De Uithof’. Since 2008, the institute has been affiliated with the University Medical Center Utrecht, advancing the translation of research into clinical practice. The Hubrecht Institute has a partnership with the European Molecular Biology Laboratory (EMBL).
**Terms of employment**
Depending on education and experience the minimum salary is €2.770 and the maximum salary is €3.539 gross per month for a full-time appointment (scale P cao Nederlandse Universiteiten/KNAW). This is exclusive of 8% vacation allowance, 8.3% year-end bonus, travel allowance, internet allowance, home working allowance and pension accrual with ABP.
The KNAW offers its staff an excellent package of secondary benefits. A package that meets the different needs of employees depending on their stage of life, lifestyle or career ambitions. For example, by working an extra two hours a week, it is possible to increase the number of days off from 29 to 41 days a year (with full-time employment).
For a complete overview of the terms of employment, please refer to the web page: werken bij de KNAW.
**Diversity & Inclusion**
We will not respond to any supplier enquiries based on this job advertisement.
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