Md/phd Student

5 maanden geleden

Utrecht, Nederland Prinses Máxima Centrum Voltijd

The Princess Máxima Center for Pediatric Oncology is a research hospital concentrating healthcare, research, and education of pediatric cancer in a single location in Utrecht. The institute aims to provide the highest level of care for all children with cancer and has the ambition to cure all children of cancer and improve quality of life. The center brings together the best possible care and scientific research, creating a unique interdisciplinary institute for pediatric oncology in Europe.

**Research project**

Hematopoietic cell transplantation (HCT) is a life-saving therapy for various diseases, including leukemia. However, despite its use in >40.000 patients annually, the mechanisms by which transplanted stem cells regenerate blood in the recipient remain largely unknown. In a previous study, we found that clonal populations of mutant stem cells (clonal hematopoiesis) can be found in a substantial number of long-term stem cell transplantation survivors. In the current project, we aim to dissect the growth dynamics of mutant clones after transplantation, and to identify cell-extrinsic factors that drive or mitigate clonal expansion, which may provide therapeutic targets. You will be involved in the entire scope of translational research - from patient recruitment to fundamental cell biology studies. You will assess clinical parameters, blood cell counts as well as molecular characteristics of these cells, and relate these to clinical exposures and outcome. You will coordinate study visits, analyze the clinical data and perform the required wet-lab experiments. You will work closely together with another PhD student, a clinical trial manager and a wet-lab technician. Within the context of the study, you are encouraged to develop and test your own research hypotheses and ideas.

This is a 4-year project that is subsidized by NWO. The results of this study are expected to contribute to more effective, safer stem cell transplantations, in order to improve the survival and quality of life of children with cancer.

**Profile**

**Qualifications**
- MD degree
- Excellence in the Dutch language, required for patient recruitment
- Demonstrated experience in research
- Interest in translational childhood cancer research
- Advanced in English speaking and writing
- You enjoy working in and contributing to a multidisciplinary team
- You have a creative mind, and you like to contribute to the development of our research group

**Our job offer**

We offer a challenging position in an international, multidisciplinary research environment, which combines clinical studies, stem cell biology and genomics. You will start on a temporary position for the duration of one year, with the possibility to extend upon satisfaction. Your gross monthly salary will start in FWG 50-6 with a salary of €3.824;
- gross a month for a fulltime working week (36 hours). You also receive 8,33% holiday allowance and 8,33 % end-of-year bonus. The Princess Máxima Center operates according to the collective labor agreement ‘cao ziekenhuizen’.

**The Belderbos Group**

**Contact**

Please provide:

- An up-to-date resume/CV
- A short motivation letter (maximum one A4)
- Contact information of 2-3 references

For more information about this position, you are welcome to contact Dr. Mirjam Belderbos.
- Acquisitie naar aanleiding van deze vacature wordt niet op prijs gesteld._

**Details**:

- 36 hours per week
- FWG: 50-6
- €3.824,**Contactpersoon**:
Mirjam Belderbos

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