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Postdoctoral Researcher in Serial Crystallography

2 maanden geleden


Amsterdam, Noord-Holland, Nederland VU Amsterdam Voltijd

Position Overview

The field of Serial Crystallography (SX) is rapidly evolving, enabling the visualization of macromolecular interactions with light. This innovative approach employs a "pump–probe" technique, utilizing a brief UV-Visible laser pulse to excite chromophores within the molecule, followed by an X-ray pulse to investigate the resulting state at a specified delay post-excitation. The resulting light-induced X-ray crystallographic electron densities provide insights into reactions and excited-state dynamics. A postdoctoral research opportunity is available to explore light-responsive proteins critical for photosynthesis and photobiology, with SX findings complemented by time-resolved spectroscopy.

Key Responsibilities

  • Develop a comprehensive data processing pipeline for crystallographic datasets.
  • Engage actively in the group's time-resolved serial crystallography experiments.
  • Contribute to the organization and execution of serial crystallography experiments.
  • Conduct SX experiments with a strong focus on data analysis.
  • Examine the photo-regulatory and molecular responses of various proteins to light exposure.
  • Integrate SX observations with time-resolved spectroscopy results.

Candidate Profile

  • PhD in physics, physical chemistry, biophysics, biochemistry, or related fields.
  • Experience and knowledge in structural biology and serial crystallography or large-scale data analysis.
  • Familiarity with CrystFEL or DIALS data processing software is highly advantageous.
  • Proficiency in Phenix and CCP4.
  • Strong programming skills in Python or a similar language.
  • Interest in collaborating within a multidisciplinary environment.
  • Fluency in English is essential.

As an institution, we are committed to fostering equal opportunities for all, recognizing that diversity enriches our teaching, research, and service. We value diverse backgrounds and experiences and are dedicated to creating an inclusive community where diversity is embraced as an asset.

We acknowledge that each individual possesses a unique combination of skills, expertise, and perspectives. Therefore, we encourage all individuals who identify with the profile to consider applying, even if they do not meet every requirement.

What We Offer

This role presents a challenging opportunity within a socially responsible organization. At VU Amsterdam, your contributions will enhance education, research, and service for a better world. In return for your efforts, we provide:

  • A competitive salary starting at €3,000 (gross per month, full-time basis, based on UFO profile Researcher 4; actual salary depends on qualifications and experience).
  • A position with a minimum commitment of 0.8 FTE, initially for one year, with potential for extension.

We also offer attractive benefits, including:

  • A full-time 38-hour workweek with a holiday leave entitlement of hours per year; for those working 40 hours, an additional 96 holiday leave hours annually, calculated pro rata for part-time employees.
  • 8% holiday allowance and an end-of-year bonus of 8.3%.
  • Discounts on cultural events and courses at the Griffioen Cultural Center.
  • Support for commuting expenses.
  • Discounts on collective insurance plans (healthcare and car insurance).