PhD Position in Nanoparticles for Intestinal Diseases

1 maand geleden

Groningen, Groningen, Nederland Rijksuniversiteit Groningen Voltijd
Job Description

Intestinal fibrosis is a significant complication in chronic inflammatory bowel diseases (IBD) such as Crohn's Disease and ulcerative colitis. It is a challenging therapeutic problem to diagnose and treat. Intestinal tissue is easily accessible with nanoparticles, offering excellent opportunities for therapy and diagnosis, e.g., a theranostic approach.

Research Objectives

The current proposal aims to identify (I) relevant target receptors in diseased intestinal tissue, focusing on macrophages and fibroblasts, (II) prepare lipid nanoparticles that bind to these receptors, enabling delivery of fluorescence labels and experimental drugs into target cells, and finally (III) test the application of these constructs to monitor disease activity and effects of drugs.

Research will be conducted in cultures of fibroblasts and precision-cut intestinal slices from IBD patients. The goal is to image fibroblast and macrophage accumulation and explore the effectiveness of a cell-specific therapeutic approach.

Organization

The vacancy is within the groups of Prof. Dr. Klaas Poelstra and Prof. Dr. Peter Olinga at the Groningen Research Institute of Pharmacy, Faculty of Science and Engineering, University of Groningen, and Prof. dr. Klaas Nico Faber, University Medical Center Groningen.

The research project aims to develop innovative cell-selective delivery strategies for nanoparticles to fibroblasts and macrophages for the imaging and treatment of intestinal fibrosis associated with Inflammatory Bowel Diseases.

Requirements
  • A M.Sc. degree in Medical Biology, Pharmacy, Pharmaceutical Sciences, or a related field.
  • Research experience in molecular biology, preferably with experience in qPCR, western blotting, FACS, immunohistochemistry, and/or mammalian cell cultures.
  • Ability to think analytically and creatively.
  • High motivation.
  • Ability to work in an international team.
  • An integrative and cooperative personality with excellent communicative and social skills.
  • Fluent proficiency in English – written and oral.
Conditions of Employment

We offer you in accordance with the Collective Labour Agreement for Dutch Universities:

  • A salary of € 2,770 (salary scale PhD candidates) gross per month in the first year, up to a maximum of € 3,539 gross per month in the fourth and final year, based on a full-time position.
  • A holiday allowance of 8% gross annual income and an 8.3% year-end bonus.
  • A temporary position of one year with the option of renewal for another three years; prolongation of the contract is contingent on sufficient progress in the first year to indicate that you will successfully complete your PhD thesis within the next three years. A PhD training programme is part of the agreement.

  • PhD Position in Nanoparticles for Intestinal Diseases

    1 maand geleden

    Groningen, Groningen, Nederland Rijksuniversiteit Groningen Voltijd

    Job DescriptionIntestinal fibrosis is a significant complication in chronic inflammatory bowel diseases (IBD) such as Crohn's Disease and ulcerative colitis. It is a challenging therapeutic problem to diagnose and treat. Intestinal tissue is easily accessible with nanoparticles, offering excellent opportunities for therapy and diagnosis, e.g., a theranostic...

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    Job DescriptionIntestinal fibrosis is a significant complication in chronic inflammatory bowel diseases (IBD) such as Crohn's Disease and ulcerative colitis. It is a challenging therapeutic problem, difficult to diagnose and treat. Intestinal tissue is easily accessible with nanoparticles, offering excellent opportunities for therapy and diagnosis, e.g., a...

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    Groningen, Groningen, Nederland Rijksuniversiteit Groningen Voltijd

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  • PhD Position in Nanoparticles for Intestinal Diseases

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    Job DescriptionIntestinal fibrosis is a significant complication in chronic inflammatory bowel diseases (IBD) such as Crohn's Disease and ulcerative colitis. It is a challenging therapeutic problem, difficult to diagnose and treat. Intestinal tissue is easily accessible with nanoparticles, offering excellent opportunities for therapy and diagnosis, e.g., a...

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    Groningen, Groningen, Nederland Rijksuniversiteit Groningen Voltijd

    Job DescriptionIntestinal fibrosis is a significant complication in chronic inflammatory bowel diseases (IBD) such as Crohn's Disease and ulcerative colitis. It is a challenging therapeutic problem to diagnose and treat. Intestinal tissue is easily accessible with nanoparticles, offering excellent opportunities for therapy and diagnosis, e.g., a theranostic...

  • PhD Position in Nanoparticles for Intestinal Diseases

    1 maand geleden

    Groningen, Groningen, Nederland Rijksuniversiteit Groningen Voltijd

    Job DescriptionIntestinal fibrosis is a significant complication in chronic inflammatory bowel diseases (IBD) such as Crohn's Disease and ulcerative colitis. It is a challenging therapeutic problem, difficult to diagnose and treat. Intestinal tissue is easily accessible with nanoparticles, offering excellent opportunities for therapy and diagnosis, e.g., a...

  • PhD Position in Nanoparticles for Intestinal Diseases

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    Groningen, Groningen, Nederland Rijksuniversiteit Groningen Voltijd

    Job DescriptionAt the Groningen Research Institute of Pharmacy, we are seeking a highly motivated PhD candidate to join our team in the field of nanomedicine for intestinal fibrosis associated with inflammatory bowel diseases (IBD).The successful candidate will be part of a multidisciplinary research project that aims to develop innovative cell-selective...

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