PhD Researcher in Microfluidic Lipid Nanoparticle Formation

3 weken geleden


Enschede, Overijssel, Nederland University of Twente Voltijd

**NANOSPRESSO-NL Consortium: A Groundbreaking Project in Personalized LNP Therapeutics**

As a highly motivated PhD researcher, you will be part of the interdisciplinary NANOSPRESSO-NL consortium, working on the development of a disruptive technology for decentralized and small-scale bedside production of high-quality and affordable nucleic acid nanomedicines for the treatment of rare diseases. Your primary focus will be on the microfluidic formation of lipid nanoparticles (LNPs) that carry nucleic acid therapeutics such as mRNA.

**Key Responsibilities:**

  • Unravel the coupling between fluid mechanics and physicochemistry of LNP self-assembly
  • Design and fabricate microfluidic chips to study LNP formation
  • Master a range of experimental techniques, including ultra-high-speed imaging and confocal imaging
  • Develop numerical simulations and theory to test understanding

**Collaboration and Training:**

You will collaborate closely with the Laboratory for Clinical Chemistry & Hematology of the University Medical Center Utrecht, SINTEF in Trondheim (Norway), and a pharmaceutical spin-off company of the UT (Solstice Pharmaceuticals). As part of the Twente Graduate School, you will have access to a training program that will help you develop your skills and knowledge.

**Requirements:**

  • Strong background in physical chemistry, (applied) physics, chemical engineering, biomedical engineering, or a closely related discipline
  • Excellent communication skills, including fluency in English
  • Experimental experience and creativity in the lab
  • Knowledge of fluid mechanics, microfluidics, microscopy, and/or physical chemistry is a plus

**What We Offer:**

  • Full-time PhD position for four years with a qualifier in the first year
  • Opportunity to work in a stimulating scientific environment
  • Competitive salary and benefits, including a holiday allowance, end-of-year bonus, and pension scheme
  • Flexible working hours and a minimum of 232 leave hours per year


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