PhD Position in Nanoparticles for Intestinal Diseases

1 maand geleden

Groningen, Groningen, Nederland Rijksuniversiteit Groningen Voltijd
Job Description

Intestinal fibrosis is a significant complication in chronic inflammatory bowel diseases (IBD) such as Crohn's Disease and ulcerative colitis. It is a challenging therapeutic problem, difficult to diagnose and treat. Intestinal tissue is easily accessible with nanoparticles, offering excellent opportunities for therapy and diagnosis, e.g., a theranostic approach.

Research Objectives
  • Find relevant target receptors in diseased intestinal tissue, focusing on macrophages and fibroblasts.
  • Prepare lipid nanoparticles that bind to these receptors, enabling delivery of fluorescence labels and experimental drugs into target cells.
  • Test the application of these constructs to monitor disease activity and effects of drugs.

Research will be performed in cultures of fibroblasts and precision-cut intestinal slices from IBD patients. The aim is to image fibroblast and macrophage accumulation and explore the effectiveness of a cell-specific therapeutic approach.

Collaboration and Environment

The vacancy is within the groups of Prof. Dr. Klaas Poelstra and Prof. Dr. Peter Olinga at the Groningen Research Institute of Pharmacy, Faculty of Science and Engineering, University of Groningen, and Prof. dr. Klaas Nico Faber, University Medical Center Groningen. The research project aims to develop innovative cell-selective delivery strategies for nanoparticles to fibroblasts and macrophages for the imaging and treatment of intestinal fibrosis associated with Inflammatory Bowel Diseases.

About the University

The University of Groningen (founded in 1614) has a long tradition of academic excellence, being one of the oldest research universities in Europe. The University is currently in or around the top 100 on several influential ranking lists. Approximately 30,000 students are enrolled, and about 1,500 PhD students work on their theses. The city of Groningen is a historic town and among the ten biggest cities in The Netherlands. It is a vibrant student town with a direct train connection to Schiphol Airport near Amsterdam.

About HTRIC

The Health Technology Research and Innovation Cluster (HTRIC) is rethinking the future of healthcare. We bring academic research, health technology, and clinical practice together to tackle the challenges faced by today's healthcare system. Our aspiration is to have more healthy years of life for the people around us

Requirements
  • A M.Sc. degree in Medical Biology, Pharmacy, Pharmaceutical Sciences, or a related field.
  • Research experience in the field of molecular biology, preferably with experience in qPCR, western blotting, FACS, immunohistochemistry, and/or mammalian cell cultures.
  • Capacity to think analytically and creatively.
  • High motivation.
  • Ability to work in an international team.
  • An integrative and cooperative personality with excellent communicative and social skills.
  • Fluent proficiency in English – written and oral.

  • PhD Position in Nanoparticles for Intestinal Diseases

    1 maand geleden

    Groningen, Groningen, Nederland Rijksuniversiteit Groningen Voltijd

    Job DescriptionIntestinal fibrosis is a significant complication in chronic inflammatory bowel diseases (IBD) such as Crohn's Disease and ulcerative colitis. It is a challenging therapeutic problem to diagnose and treat. Intestinal tissue is easily accessible with nanoparticles, offering excellent opportunities for therapy and diagnosis, e.g., a theranostic...

  • PhD Position in Nanoparticles for Intestinal Diseases

    1 maand geleden

    Groningen, Groningen, Nederland Rijksuniversiteit Groningen Voltijd

    Job DescriptionIntestinal fibrosis is a significant complication in chronic inflammatory bowel diseases (IBD) such as Crohn's Disease and ulcerative colitis. It is a challenging therapeutic problem to diagnose and treat. Intestinal tissue is easily accessible with nanoparticles, offering excellent opportunities for therapy and diagnosis, e.g., a theranostic...

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    Groningen, Groningen, Nederland Rijksuniversiteit Groningen Voltijd

    Job DescriptionIntestinal fibrosis is a significant complication in chronic inflammatory bowel diseases (IBD) such as Crohn's Disease and ulcerative colitis. It is a challenging therapeutic problem, difficult to diagnose and treat. Intestinal tissue is easily accessible with nanoparticles, offering excellent opportunities for therapy and diagnosis, e.g., a...

  • PhD Position in Nanoparticles for Intestinal Diseases

    3 weken geleden

    Groningen, Groningen, Nederland Rijksuniversiteit Groningen Voltijd

    Job DescriptionIntestinal fibrosis is a significant complication in chronic inflammatory bowel diseases (IBD) such as Crohn's Disease and ulcerative colitis. It is a challenging therapeutic problem, difficult to diagnose and treat. Intestinal tissue is easily accessible with nanoparticles, offering excellent opportunities for therapy and diagnosis, e.g., a...

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    Groningen, Groningen, Nederland Rijksuniversiteit Groningen Voltijd

    Job DescriptionIntestinal fibrosis is a significant complication in chronic inflammatory bowel diseases (IBD) such as Crohn's Disease and ulcerative colitis. It is a challenging therapeutic problem, difficult to diagnose and treat. Intestinal tissue is easily accessible with nanoparticles, offering excellent opportunities for therapy and diagnosis, e.g., a...

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