Principal Scientist, Chemistry

At Genmab, we are dedicated to building extra[not]ordinary futures, together, by developing antibody products and groundbreaking, knock-your-socks-off KYSO antibody medicines that change lives and the future of cancer treatment and serious diseases. We strive to create, champion and maintain a global workplace where individuals' unique contributions are valued and drive innovative solutions to meet the needs of our patients, care partners, families and employees.

Our people are compassionate, candid, and purposeful, and our business is innovative and rooted in science. We believe that being proudly authentic and determined to be our best is essential to fulfilling our purpose. Yes, our work is incredibly serious and impactful, but we have big ambitions, bring a ton of care to pursuing them, and have a lot of fun while doing so.

Does this inspire you and feel like a fit? Then we would love to have you join us

Role
As a key member of our new chemical lab, you will play an important role in driving the development of innovative Antibody Drug Conjugates in a fast-paced and innovative biotech environment. Your expertise in medicinal chemistry and antibody drug conjugates will be instrumental in designing, synthesizing, and optimizing novel compounds to advance our research and development pipeline. You will contribute to multidisciplinary new discovery projects. You have an expert oversight over the field of medicinal chemistry, ADC conjugation chemistry and payload chemistry. In this role, you will be hands-on and work closely with other Discovery teams, such as Product Discovery, Antibody Engineering, Data Science and High-Throughput Screening to develop state-of-the-art ADCs.

If you are an innovative and driven scientist looking to make a significant impact in a cutting-edge biotech, we invite you to apply for this exciting opportunity

Responsibilities

• Compound Design and Synthesis: Design, develop and synthesize novel organic compounds, payloads and linkers to support drug discovery and development projects. Apply medicinal chemistry principles to design compounds with optimal pharmacological properties and ensure conjugation to Genmab's antibody formats. Contribute to the development and implementation of innovative synthetic methodologies and strategies to enhance efficiency, scalability, and overall project success.
• Optimization and Analysis: Conduct structure-activity relationship (SAR) studies to optimize lead compounds. Utilize advanced analytical techniques, including HPLC, LC-MS, NMR, and other methods to characterize and purify ADC compounds and linker-payloads.
• Collaboration: Participate and lead cross-functional teams project teams and meetings to integrate chemistry efforts into broader research and development activities. Contribute to the planning and execution of experiments that drive project milestones. Oversee all outsourcing activities to various CROs around the globe.
• Innovation: Stay abreast of the latest scientific advancements and technologies in ADCs, payload chemistry and linker chemistry. Apply innovative approaches to solve complex problems and contribute to the development of new research strategies.
• Documentation and Reporting: Maintain accurate and detailed records of experimental procedures, results, and analyses. Prepare and present scientific reports, manuscripts, and presentations to internal and external stakeholders.
• Quality and Compliance: Ensure that all work is conducted in compliance with company policies, industry regulations, and best practices. Participate in safety and compliance training as required.

Requirements

• Educational Background: Ph.D. in Medicinal Chemistry, Organic Chemistry, or a related field, with a strong foundation in both theoretical and practical aspects of medicinal chemistry and (preferably) ADC discovery.
• Experience: Minimum of 6 years of experience in medicinal and/or organic chemistry, preferably in a startup or innovative biotech environment. Proven track record of successful compound design, synthesis, and optimization.
• Technical Skills: Proficiency in organic synthesis techniques and analytical methods, including NMR, MS, HPLC, and other relevant technologies. Experience with parallel synthesis, high-throughput screening and SAR analysis is a plus.
• Analytical Thinking: Strong problem-solving skills with the ability to analyze complex data and derive actionable insights. Demonstrated ability to design and execute experiments independently.
• Collaboration: Excellent interpersonal and communication skills with a demonstrated ability to work effectively in a team-oriented environment. Experience in collaborating with cross-functional teams is highly desirable.
• Adaptability: Ability to thrive in a fast-paced startup environment with a flexible and proactive approach to work. Willingness to take on diverse tasks and responsibilities as needed.
• Passion for Innovation: Enthusiasm for working in an innovative biotech setting and a commitment to advancing scientific research and development.

About You

• You are genuinely passionate about our purpose
• You bring precision and excellence to all that you do
• You believe in our rooted-in-science approach to problem-solving
• You are a generous collaborator who can work in teams with a broad spectrum of backgrounds
• You take pride in enabling the best work of others on the team
• You can grapple with the unknown and be innovative
• You have experience working in a fast-growing, dynamic company (or a strong desire to)
• You work hard and are not afraid to have a little fun while you do so

Locations
Genmab maximizes the efficiency of an agile working environment, when possible, for the betterment of employee work-life balance. Our offices are crafted as open, community-based spaces that work to connect employees while being immersed in our powerful laboratories. Whether you're in one of our office spaces or working remotely, we thrive on connecting with each other to innovate.

About Genmab
Genmab is an international biotechnology company with a core purpose to improve the lives of patients through innovative and differentiated antibody therapeutics. For 25 years, its hard-working, innovative and collaborative team has invented next-generation antibody technology platforms and harnessed translational, quantitative and data sciences, resulting in a proprietary pipeline including bispecific T-cell engagers, antibody-drug conjugates, next-generation immune checkpoint modulators and effector function-enhanced antibodies. By 2030, Genmab's vision is to transform the lives of people with cancer and other serious diseases with Knock-Your-Socks-Off (KYSO) antibody medicines.

Established in 1999, Genmab is headquartered in Copenhagen, Denmark with international presence across North America, Europe and Asia Pacific. For more information, please visit and follow us on LinkedIn and X.

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Please note that if you are applying for a position in the Netherlands, Genmab's policy for all permanently budgeted hires in NL is initially to offer a fixed-term employment contract for a year, if the employee performs well and if the business conditions do not change, renewal for an indefinite term may be considered after the contract.