PhD position Photopharmacology
5 maanden geleden
Job description
Without biological membranes, there would be no life as we know it. Transport of molecules and information across these membranes is carried out by integral membrane protein channels, receptors, pumps and transporters. Living cells maintain chemical gradients and electrical potential differences across their membranes using proteins that represent the majority of all current drug targets. Therefore, membrane proteins have been the focus of intense efforts to obtain high resolution macromolecular structure information. However, the current lack of experimental methods to carry out time-resolved structural studies of membrane proteins at physiological temperatures and under physiological gradients leaves a gigantic blind spot is our mechanistic understanding.
This project is a part of an ERC-funded consortium that will address this challenge by bringing together complementary expertise in membrane protein biology, time-resolved structural studies, photochemistry and nano fabrication methods. The role of the PhD working in this position will be to design, synthesize and evaluate new light-activated molecules to deliver protein transport substrates with unprecedented efficiency. Within this team, the PhD student will be supported, among others, by a dedicated postdoc researcher with expertise in quantum chemistry for guiding the development of light-activated molecules.
Organization
The vacancy is within the newly formed Department of Medicinal Chemistry, Photopharmacology and Imaging at the Groningen Research Institute of Pharmacy, Faculty of Science and Engineering, University of Groningen. The ERC-funded (ERC Synergy GRAIL) project aims at providing molecular basis for the instant, photochemical release of ligands for proteins studied in unprecedented level of structural dynamics using equipment developed by the GRAIL consortium.
The University of Groningen (founded in 1614) has a long tradition of academic excellence, being one of the oldest research universities in Europe. The University is currently in or around the top 100 on several influential ranking lists. Currently approximately 34,000 students are enrolled and about 1,500 PhD students work on their theses. The city of Groningen is a historic town and among the ten biggest cities in The Netherlands. It is a vibrant student town with a direct train connection to Schiphol Airport near Amsterdam.
The Groningen Research Institute of Pharmacy (GRIP) is part of the Faculty of Science and Engineering (FSE) of the University of Groningen and collaborates closely with the University Medical Center Groningen (UMCG). The pharmaceutical and medical research within GRIP and the UMCG is very multidisciplinary. This project aims to develop light-activation processes for the emerging field of time-resolved structural biology, fitting perfectly into the fundamental and applied work performed in the Department of Medicinal Chemistry, Photopharmacology and Imaging at GRIP.
Qualifications
We are looking for an enthusiastic and talented PhD candidate with
a M.Sc. degree in (Synthetic) Organic Chemistry research experience in the field of photochemistry, photocleavable protecting groups and/or photopharmacology will be seen as a strong asset capacity to think analytically and creatively high motivation ability to work in an international team and collaborate with several research centres in Europe in a streamlined and professional way an integrative and cooperative personality with excellent communicative and social skills fluent proficiency in English – written and oral.Applicants whose first language is not English must submit evidence of competency in English, please see University of Groningen’s English Language Requirements for details.
Organisation
Conditions of employment
We offer you in accordance with the Collective Labour Agreement for Dutch Universities
a salary of € 2,770 (salary scale PhD candidates) gross per month in the first year, up to a maximum of € 3,539 gross per month in the fourth and final year, based on a full-time position a holiday allowance of 8% gross annual income an 8.3% year-end bonus a temporary position of one year with the option of renewal for another three years; prolongation of the contract is contingent on sufficient progress in the first year to indicate that you will successfully complete your PhD thesis within the next three years. A PhD training programme is part of the agreement.The preferred starting date is between September 1st and October 1st 2024.
-
PhD Position in Photopharmacology
3 weken geleden
Groningen, Groningen, Nederland Rijksuniversiteit Groningen VoltijdJob DescriptionOur research group at the University of Groningen is seeking a highly motivated PhD candidate to join our team in the field of photopharmacology. The successful candidate will be working on the design, synthesis, and evaluation of new light-activated molecules for protein transport substrates.Project OverviewThe project is part of an...
-
Postdoctoral Researcher in Computational Photopharmacology
1 maand geleden
Groningen, Groningen, Nederland Rijksuniversiteit Groningen VoltijdJob DescriptionAs a Postdoctoral Researcher in Computational Photopharmacology, you will be part of an ERC-funded consortium that aims to address the challenge of time-resolved structural studies of membrane proteins at physiological temperatures and under physiological gradients.The role of the postdoctoral researcher will be to provide computational...
-
Postdoctoral Researcher in Computational Photopharmacology
4 weken geleden
Groningen, Groningen, Nederland Rijksuniversiteit Groningen VoltijdJob DescriptionWe are seeking a highly skilled Postdoctoral Researcher to join our team in the Department of Medicinal Chemistry, Photopharmacology and Imaging at the Groningen Research Institute of Pharmacy, Faculty of Science and Engineering, University of Groningen.Project OverviewThis project is part of an ERC-funded consortium that aims to address the...
-
Postdoctoral Researcher in Computational Photopharmacology
1 maand geleden
Groningen, Groningen, Nederland Rijksuniversiteit Groningen VoltijdJob DescriptionWe are seeking a highly skilled Postdoctoral Researcher to join our team in the Department of Medicinal Chemistry, Photopharmacology and Imaging at the Groningen Research Institute of Pharmacy, Faculty of Science and Engineering, University of Groningen.Project OverviewThis project is part of an ERC-funded consortium that aims to address the...
-
Postdoctoral Researcher Computational Photopharmacology
5 maanden geleden
Groningen, Nederland Rijksuniversiteit Groningen VoltijdJob description Without biological membranes, there would be no life as we know it. Transport of molecules and information across these membranes is carried out by integral membrane protein channels, receptors, pumps and transporters. Living cells maintain chemical gradients and electrical potential differences across their membranes using proteins...
-
Phd Position
4 maanden geleden
Groningen, Nederland UMCG Voltijd**Functiebeschrijving**: The project is a continuation of ongoing research into the dysregulation of immune tolerance in AAV, particularly concerning the role of Tregs. AAV are rare, chronic, relapsing autoimmune diseases characterized by inflammation of small blood vessels, commonly affecting the kidneys, lungs, and upper airways. Dysregulation of immune...
-
Phd Position
5 maanden geleden
Groningen, Nederland UMCG Voltijd**Functiebeschrijving**: The project will be focused on: 1) material science for developing strategies for efficient EVs retention into a protein-based hydrogel system; 2) study of the mechano-structural properties of the target tissue for designing promising architectures for bioprinting; 3) bioprinting technology for manufacturing constructs with refined...
-
PhD Position in Relational Drivers of Audit Quality
1 maand geleden
Groningen, Groningen, Nederland Rijksuniversiteit Groningen VoltijdAbout the PhD PositionThe University of Groningen's Faculty of Economics and Business is seeking a highly motivated PhD candidate to join its research programme on the topic of relational drivers of audit quality. This PhD position is part of a research programme generously funded by the Foundation for Auditing Research (FAR), involving the commitment of all...
-
PhD Position in Relational Drivers of Audit Quality
3 weken geleden
Groningen, Groningen, Nederland Rijksuniversiteit Groningen VoltijdAbout the PhD PositionThe University of Groningen's Faculty of Economics and Business is seeking a highly motivated PhD candidate to join its research programme on the topic of relational drivers of audit quality. This PhD position is part of a research programme generously funded by the Foundation for Auditing Research (FAR), involving the commitment of all...
-
PhD position in Organic Synthesis
2 maanden geleden
Groningen, Nederland University of Groningen VoltijdJob description We are looking for a PhD candidate in the group of Prof. A. J. Minnaard, who leads a natural product synthesis group at the Stratingh Institute for Chemistry (see: minnaardgroup.nl). Within the framework of his Ammodo Science Award, the position focusses on the total synthesis of membrane components of M. tuberculosis. In an ongoing...
-
PhD Position in Auditing and Behavioral Research
1 week geleden
Groningen, Groningen, Nederland Rijksuniversiteit Groningen VoltijdAbout the PhD Position The Rijksuniversiteit Groningen is currently seeking a talented PhD candidate to join its research team in the field of auditing and behavioral research. As a PhD candidate, you will be working on a fully funded research project examining the relational drivers of audit quality, specifically focusing on the dynamics between...
-
PhD Position in Biophysics
3 maanden geleden
Groningen, Nederland University of Groningen VoltijdJob description The Heinemann Lab at the University of Groningen (Netherlands) aims to understand how cellular metabolism functions and how metabolism controls other cellular processes. The lab has recently found that cellular metabolism does not operate beyond a certain Gibbs energy dissipation rate (Niebel et al, 2019, Nature Metabolism). This observation...
-
PhD Positions in Molecular Microbiology
1 maand geleden
Groningen, Groningen, Nederland Rijksuniversiteit Groningen VoltijdJob DescriptionWe are seeking highly motivated and enthusiastic PhD candidates to join our Systems Biology of Predatory Bacteria group at the Rijksuniversiteit Groningen. Our research focuses on understanding the life cycle of the bacterial predator Bdellovibrio bacteriovorus and its interactions with prey bacteria.Research FocusOur group uses systems...
-
PhD Position in Relational Drivers of Audit Quality
2 weken geleden
Groningen, Groningen, Nederland Rijksuniversiteit Groningen VoltijdAbout the PhD PositionThe Graduate School of the Faculty of Economics and Business at the University of Groningen is seeking a PhD candidate to work on the topic of Relational Drivers of Audit Quality. This fully funded position is part of a research programme generously funded by the Foundation for Auditing Research (FAR), involving the commitment of all...
-
Phd Position Social-historical Analysis of Regional
5 maanden geleden
Groningen, Nederland Rijksuniversiteit Groningen VoltijdWithin the Chair Group of Economic and Social History, Faculty of Arts at the University of Groningen, the Netherlands, a fully funded PhD position is currently available. The position will be within the ERC-funded project “Coping with decline: Comparative social-historical analysis of depopulation and community welfare in Europe, 1950-2022...
-
Phd Position Financial Economics of Slavery
1 maand geleden
Groningen, Nederland Rijksuniversiteit Groningen VoltijdThe PhD position is embedded in the research programme Economics, Econometrics and Finance of FEB’s Research Institute. The project will be supervised by Abe de Jong, in cooperation with Tim Kooijmans (RMIT) and Peter Koudijs (NYU). Organisation Since its foundation in 1614, the University of Groningen has enjoyed an international reputation as a dynamic...
-
Phd Position Migration and Human Capital
2 maanden geleden
Groningen, Nederland Rijksuniversiteit Groningen VoltijdSince its foundation in 1614, the University of Groningen has enjoyed an international reputation as a dynamic and innovative center of higher education offering high-quality teaching and research. Belonging to the best research universities of Europe and joining forces with prestigious partner universities and networks, the University of Groningen is truly...
-
PhD Position in Relational Drivers of Audit Quality
2 weken geleden
Groningen, Groningen, Nederland Rijksuniversiteit Groningen VoltijdAbout the PhD PositionThe Rijksuniversiteit Groningen is seeking a PhD candidate to contribute to a research programme on the relational drivers of audit quality. This project aims to identify how relational dynamics between upper echelon actors and auditors shape audit quality.Research ObjectivesThe PhD candidate will work on the following research...
-
Groningen, Groningen, Nederland Rijksuniversiteit Groningen VoltijdAbout the PhD ProjectWe are seeking a highly motivated and talented PhD candidate to join our research team at the Integrated Research on Energy, Environment and Society group (IREES) within the Energy and Sustainability Research Institute Groningen (ESRIG). The successful candidate will work under the supervision of Prof. Xin Sun and will be involved in a...
-
PhD Positions in Molecular Immunology
3 weken geleden
Groningen, Groningen, Nederland Rijksuniversiteit Groningen VoltijdJob DescriptionWe are seeking highly motivated and talented researchers to join our team at the University of Groningen. The successful candidates will be part of a dynamic and innovative research environment, working on a project that aims to identify the organelle trafficking routes responsible for Weibel-Palade body (WPB) formation and secretion.Project...
