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Postdoc in Microbiome Spatial

3 maanden geleden


Amsterdam, Noord-Holland, Nederland Universiteit van Amsterdam Voltijd

What are you going to do

?

Within the CarboSupport team, other consortium members have successfully tested and identified combinations of dietary fiber and/or protein that fulfil two key criteria: (i) stimulating the in vitro production of beneficial fermentation products from microbiota sourced from porcine, humans across different age groups, and adult overweight prediabetic individuals, and (ii) supporting the gastrointestinal immune barrier, whether in the form of unfermented or fermented molecules.
Your role will involve unravelling the mechanisms through which individual microbes adapt metabolically and spatially to these specific combinations of dietary fiber and/or protein. This task entails designing synthetic microbial communities and investigating their metabolic activities, as well as their spatial dynamics and competitive interactions. Subsequently, either by you or through collaboration, experimental data and existing literature will be conducted, in conjunction with state-of-the-art proprietary tools, to construct predictive models. These models will identify which combinations of target dietary fibers are likely to stimulate beneficial microbial metabolic and spatial interactions. Ultimately, this understanding will facilitate the enhancement of both small and large intestinal health processes by modulating gut fermentation pathways.

Experience and profile:

You have/are

• a recent Ph.D. in a relevant field such as microbiology, molecular biology, biochemistry, biotechnology,

or a related discipline with one or more impactful publication(s) as first author in a peer-reviewed scientific journal;

• significant experience in microbiome research, microbial ecology. Previous experience with in vitro fermentation studies,

microbial community analysis, analytical chemistry and imaging would be advantageous.

• proficiency in molecular biology, microbiological assays, anaerobic culturing, and bioinformatics;

• (affinity to acquire) experience in bacterial physiology and computation modeling;

• an ambitious person that is a team player with an open character, who can take ownership of the research project;

• fluency in English, both written and spoken.

Our selection will be based on your scientific track record, your vision on this research project, and your ambition and skills.

Our offer

A temporary contract for 38 hours a week, preferably starting on 1 September , for the duration of 24 months, with a probation period of two months.

The salary, depending on relevant experience before the beginning of the employment contract, will be between €3. and €5. gross per month, based on a fulltime contract (38 hours a week). This is exclusive 8% holiday allowance and 8.3% end-of-year bonus. A favourable tax agreement, the '30% ruling', may apply to non-Dutch applicants. The Collective Labour Agreement of Dutch Universities is applicable.

Are you curious about our extensive package of secondary employment benefits like our excellent opportunities for study and development? Take a look here.

About the Faculty of Science and the Swammerdam Institute for Life Sciences

The Faculty of Science has a student body of around 7,, as well as 1, members of staff working in education, research or support services. Researchers and students at the Faculty of Science are fascinated by every aspect of how the world works, be it elementary particles, the birth of the universe or the functioning of the brain.

The Swammerdam Institute for Life Sciences(SILS) is located at the vibrant Amsterdam Science Park. SILS is one of eight institutes of the University of Amsterdam's Faculty of Science (FNWI). With around employees, SILS carries out internationally high-quality life science research and provides education within various university programs. Research is also carried out in close cooperation with the medical, biotech, chemical, flavor, food & agricultural, and high-tech industries, and revolves around 4 main themes, Cell & Systems biology, Neurosciences, Microbiology and Green Life Sciences.