Phd Position in Computational Metabolic Modelling
1 week geleden
Faculteit/Dienst:
Faculteit der Natuurw
, Wiskunde & Informatica
Opleidingsniveau:
Master
Functie type:
Promotieplaats
Sluitingsdatum:
Vacaturenummer:12952- Gut and oral microbiota develop rapidly during early life and are essential for our health during infancy and later in life.
Many factors potentially impact this development, including delivery modes, neonatal feeding (breast or formula), exposure to antibiotics, and maternal and infant diet.
Changes in the microbiota by these factors can, in turn, substantially impact the immune system, hence the infant's susceptibility to the development of chronic diseases.
However, the mechanisms that relate these factors to our gut and oral microbiota are still unclear.- Understanding this complex interaction will pave the way to the discovery of new targets for interventions aimed at improving health.
This position is supported by the NWA program METAHEALTH focusing on oral and metabolic health in infants.-What are you going to do?
- You are expected:
- to complete a PhD thesis within the official appointment duration of four years;
- the infant gut and oral microbiome and relate external factors, such as feeding behaviour, to changes- in the microbiota and the produced metabolites;- to use published genome scale metabolic models, tune them with genomic information from cohort studies,
- create new models, validate models with in vitro data, and develop methods for effective simulations- of communities;- to closely collaborate with researchers within the METAHEALTH project performing in vitro experiments,
- those analysing cohort data and those using different computational models. The aim is to produce- community models that represent the gut and oral microbiome for prediction of interventions that could- benefit infant health;- to contribute to the teaching effort of the group, including supervision of bachelor and master students;
- to present your results at seminars and (inter)national conferences.
What do we require?
- a degree (MSc, or equivalent) in Systems Biology, Computational Biology, Mathematical Biology or fluency in English, both written and spoken;
- interest in studying biology with computational models;
- skilled in computational research, with strong programming skills;
- a strong interest for collaboration with experimental biologists;
- desirable methodological skills: experience with (genome scale) metabolic models;
- knowledge of biochemistry and microbiology and good mathematical skills.
Our offer
- We offer a temporary contract for 38 hours per week for the duration of 4 years (the initial contract will be for a period of 18 months and after satisfactory evaluation it will be extended for a total duration of 4 years). This should lead to a dissertation (PhD thesis). We will draft an educational plan that includes attendance of courses and (international) meetings. We also expect you to assist in teaching undergraduates and master students.
- Are you curious about our extensive package of secondary employment benefits like our excellent opportunities for study and development? Take a look here.
Questions?
About us
- The Faculty of Science has a student body of around 7,000, as well as 1,600 members of staff working in education, research or support services. Researchers and students at the Faculty of Science are fascinated by every aspect of how the world works, be it elementary particles, the birth of the universe or the functioning of the brain.
- The Swammerdam Institute for Life Sciences is one of the Faculty of Science's largest institutes.
Neurosciences, Cell & Systems Biology, Microbiology and Green Life Sciences
Application- Applications should include:
- a motivation letter and CV, including a list of publications,
- contact information of referees.
- Please mention the months (not just years) in your CV when referring to your education and work experience.
- A knowledge security check can be part of the selection procedure.
- The UvA is an equalopportunity employer. We prioritize diversity and are committed to creating an inclusive environment for everyone. We value a spirit of enquiry and perseverance, provide the space to keep asking questions, and promote a culture of curiosity and creativity._
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