Lab Technician for Laboratory Genetic Metabolic

4 weken geleden

AmsterdamZuidoost, Nederland Amsterdam UMC Voltijd

**About the project**:
**Lysosomes** are known as the recycling centers of the cell, breaking down and recycling cellular waste, macromolecules, and organelles to maintain cell health. As we age, lysosomal function can decline, leading to an accumulation of cellular debris and dysfunctional proteins, which is thought to contribute to the aging process and age-related diseases. Emerging research suggests that enhancing lysosomal function may improve cellular health and longevity. By measuring lysosomal activity, we can gain insights into how these organelles influence aging and identify potential therapeutic targets. For example, assays that measure the degradation rate of specific substrates can indicate lysosomal efficiency, while imaging techniques can reveal changes in lysosome number and distribution within cells. Given the complexity of lysosomal functions, it is important to establish robust and sensitive protocols for their measurements.

**About the role**:

- Design and refine experimental protocols to assess lysosomal functions, leveraging existing methods for mammalian sample analysis;
- Process samples for mass spectrometry analysis to study lysosomal components;
- _ C. elegans_ cultures;
- Perform imaging analyses, including the use of confocal microscopy and staining techniques, to investigate lysosomal properties.

**Profile**:
We are looking for an enthusiastic technician with at least 3 years work experience and with:

- An HLO, Bachelor’s or Master’s degree in Life Sciences, Biochemistry, Medical Biology, or a related field;
- Experience in mass spectrometry analysis and worm culture is appreciated but not required;
- Proficiency in both oral and written English required to perform this position. Excellent communication and organizational skills and the ability to work in a dynamic group are essential.

**Our offer**:

- A flying start to your career in scientific research.
- Plenty of room for personal development with a wide range of training & development of academic skills
- Working on large-scale and own research, with motivated colleagues
- A contract for 6 months with the prospect of extension for the duration.
- Salary scale: 7M: € 2.975_ _tot € 4.214 bruto (based on a fulltime workweek), depending on qualifications and experience.
- Additional benefits including an 8.3% end-of-year bonus and 8% holiday pay. Calculate your net salary here.
- Your pension is accrued at BeFrank. A modern, understandeble en fair pension
- Excellent accessibility with public transportation and reimbursement of a large portion of your travel expenses. Additionally, we have plenty of parking spaces at the AMC location and a good bicycle scheme.

**About the workplace**:
**Laboratory Genetic Metabolic Disease (Lab GMD)** of Amsterdam UMC, location AMC combines diagnostic and research specialized in metabolism in a broad context, ranging from rare inherited metabolic diseases to cancer and age-related metabolic diseases. Within the Lab GMD, the Translational Metabolism group led by **Prof. Dr. Riekelt Houtkooper** focuses on different topics, among them, the molecular regulation of metabolic disease and how disturbances in metabolic pathways that underlie metabolic disease can be targeted as a therapy. The goal of our research is to translate our findings into future therapies that help prevent or cure disease.

**Let's meet**:
A reference check, screening and hiring test may be part of the procedure. Read here whether that applies to you. If you join us, we ask you for a VOG (Certificate of Good Conduct).

Acquisition in response to this vacancy is not appreciated.

  • Lab Technician for Laboratory Genetic Metabolic

    5 dagen geleden

    Amsterdam-Zuidoost, Noord-Holland, Nederland Amsterdam UMC Voltijd

    About the project:Lysosomes are known as the recycling centers of the cell, breaking down and recycling cellular waste, macromolecules, and organelles to maintain cell health. As we age, lysosomal function can decline, leading to an accumulation of cellular debris and dysfunctional proteins, which is thought to contribute to the aging process and age-related...

  • Laboratory Technician

    6 dagen geleden

    Amsterdam, Noord-Holland, Nederland Aminoverse B.V Voltijd € 2.000

    Explorers wanted Are you fascinated by enzymes, biotechnology and genetics? Do you want to work on exciting science projects with your colleagues in the lab? Have you ever dreamt of creating products that help making the world more sustainable and more productive? Then you've come to the right place. Aminoverse is a young biotech company in Nuth, Netherlands...

  • Lab Technician

    4 weken geleden

    Amsterdam, Nederland OCI Iowa Fertilizer Voltijd

    Lab Technician OCI Nitrogen Iowa is looking for a Lab Technician to join our Health, Safety, Environmental, and Quality (HSEQ) team in Wever, Iowa. This position supports laboratory staff by maintaining logs and record books, helping with special projects and troubleshooting and resolving problems. The incumbent will conduct chemical laboratory...

  • Lab Technician

    3 weken geleden

    Amsterdam, Nederland OCI Iowa Fertilizer Voltijd

    Lab Technician OCI Nitrogen Iowa is looking for a Lab Technician to join our Health, Safety, Environmental, and Quality (HSEQ) team in Wever, Iowa. This position supports laboratory staff by maintaining logs and record books, helping with special projects and troubleshooting and resolving problems. The incumbent will conduct chemical laboratory...

  • Lab Technician

    6 dagen geleden

    Amsterdam, Noord-Holland, Nederland OCI Iowa Fertilizer Voltijd

    Lab Technician OCI Nitrogen Iowa is looking for a Lab Technician to join our Health, Safety, Environmental, and Quality (HSEQ) team in Wever, Iowa. This position supports laboratory staff by maintaining logs and record books, helping with special projects and troubleshooting and resolving problems. The incumbent will conduct chemical laboratory tests to...

  • Lab technician

    5 dagen geleden

    Amsterdam, Noord-Holland, Nederland Netherlands Cancer Institute Voltijd

    Function description The Netherlands Cancer Institute (NKI) is an independent research institute located in the lively city of Amsterdam. The Institute covers all major areas of molecular and cellular cancer biology, with special emphasis on mouse tumor models, immunology, functional screens, cancer cell biology and translational research. The Netherlands...

  • Technician vacancy in Peeper Lab

    5 dagen geleden

    Amsterdam, Noord-Holland, Nederland Netherlands Cancer Institute Voltijd

    Function description The Netherlands Cancer Institute (NKI) Located in Amsterdam, NKI is an internationally renowned institute dedicated to fundamental, translational and clinical cancer research, and the only comprehensive cancer center in The Netherlands. It is a dynamic institute accommodating over 50 research groups and many advanced core...

  • Technician vacancy in Peeper Lab

    2 maanden geleden

    Amsterdam, Nederland Netherlands Cancer Institute Voltijd

    Function description The Netherlands Cancer Institute (NKI) Located in Amsterdam, NKI is an internationally renowned institute dedicated to fundamental, translational and clinical cancer research, and the only comprehensive cancer center in The Netherlands. It is a dynamic institute accommodating over 50 research groups and many advanced core...

  • Technician vacancy in Peeper Lab

    3 weken geleden

    Amsterdam, Nederland Netherlands Cancer Institute Voltijd

    Function description The Netherlands Cancer Institute (NKI) Located in Amsterdam, NKI is an internationally renowned institute dedicated to fundamental, translational and clinical cancer research, and the only comprehensive cancer center in The Netherlands. It is a dynamic institute accommodating over 50 research groups and many advanced core...

  • Lab technician

    2 maanden geleden

    Amsterdam, Nederland Netherlands Cancer Institute Voltijd

    Function description The Netherlands Cancer Institute (NKI) is an independent research institute located in the lively city of Amsterdam. The Institute covers all major areas of molecular and cellular cancer biology, with special emphasis on mouse tumor models, immunology, functional screens, cancer cell biology and translational research. The...

  • Lab technician

    3 weken geleden

    Amsterdam, Nederland Netherlands Cancer Institute Voltijd

    Function description The Netherlands Cancer Institute (NKI) is an independent research institute located in the lively city of Amsterdam. The Institute covers all major areas of molecular and cellular cancer biology, with special emphasis on mouse tumor models, immunology, functional screens, cancer cell biology and translational research. The...

  • Research Technician Oncology

    3 weken geleden

    Amsterdam-Zuidoost, Nederland Amsterdam UMC Voltijd

    **About the project**: We study the biology of cancer, specifically colorectal cancer. We aim to understand different subtypes of colorectal cancer and determine differences in cell death resistance, metabolic wiring and migratory capacity. Models used are based on primary tumor material, organoids, mouse models and cell lines. **About the role**: - You...

  • Research Technician Oncology

    6 dagen geleden

    Amsterdam-Zuidoost, Noord-Holland, Nederland Amsterdam UMC Voltijd

    About the project:We study the biology of cancer, specifically colorectal cancer. We aim to understand different subtypes of colorectal cancer and determine differences in cell death resistance, metabolic wiring and migratory capacity. Models used are based on primary tumor material, organoids, mouse models and cell lines.About the role: You will study the...

  • Test Engineer

    3 weken geleden

    Amsterdam, Nederland Brunswick Voltijd

    RESPONSIBILITIES: The Test Engineer/Technician will design and execute tests for product design, build test setups, prototype assemblies, and do lab maintenance. Designing and constructing test setups for electronic equipment testing, such as batteries and power converters. Assembling small prototype series and soldering electronic components and...

  • Office Manager

    2 weken geleden

    Amsterdam Noord, Nederland Metabolic Voltijd

    **About Metabolic** Metabolic’s mission is to transition the global economy to a fundamentally sustainable state. Based in the Netherlands, we are an international and dynamic team of around 100 people who share an ambition for catalyzing a sustainable future. Our primary language is English. **About the Position** Our Operations team plays an...

  • Technician Proteomics in Hemostasis

    2 weken geleden

    Amsterdam, Nederland Sanquin Voltijd

    **Location** - Amsterdam **Working week** - 32-36 hours **Education** - HBO **Closing date** - 15 June 2024 **Function area** - Research / Laboratory **Vacancy nr.** - 1083 **Clinical proteomics in hemostatic disorders** Congenital and acquired disorders of hemostasis represent a large clinical burden. The mission of the Medical Priority Bleeding &...

  • Office Manager

    5 dagen geleden

    Amsterdam, Noord-Holland, Nederland Metabolic Voltijd

    About MetabolicMetabolic's mission is to transition the global economy to a fundamentally sustainable state.Based in the Netherlands, we are an international and dynamic team of around 100 people who share an ambition for catalyzing a sustainable future. Our primary language is English.About the PositionOur Operations team plays an essential role in helping...

  • Phd Student Emma Center for Personalized

    2 maanden geleden

    Amsterdam-Zuidoost, Nederland Amsterdam UMC Voltijd

    **About the project**: The PhD student will work on gene therapy development for Gyrate atrophy of the choroid and retina (GACR), a rare genetic (neuro)metabolic eye disorder. Based on disease pathology, patient’s needs, ethical considerations, therapeutic developmental time lines, and current state of the art of gene therapy, we recently posed that the...

  • Phd Student Emma Center for Personalized

    33 minuten geleden

    Amsterdam-Zuidoost, Nederland Amsterdam UMC Voltijd

    **About the project**: The PhD student will work on gene therapy development for Gyrate atrophy of the choroid and retina (GACR), a rare genetic (neuro)metabolic eye disorder. Based on disease pathology, patient’s needs, ethical considerations, therapeutic developmental time lines, and current state of the art of gene therapy, we recently posed that the...

  • Lab Manager Microbiome Engineering Group

    5 dagen geleden

    Amsterdam, Noord-Holland, Nederland Visionatline Voltijd € 3.072 - € 4.103

    Lab Manager Microbiome Engineering Group. We are currently looking for a Lab Manager / technician to support the work of the newly established group "Microbiome Engineering". The group's mission is to explore the role of the microbiome in human health. Working alongside a team of microbiologists, molecular biologists, biochemists, and neurobiologists, you...